CGRP Receptor

CGRP receptor antagonists block the receptor for calcitonin gene-related peptide (CGRP), a neuropeptide. In 1982 alternative RNA processing of the calcitonin gene was shown to produce CGRP in neural tissue. The receptor is formed by calcitonin receptor-like receptor (CALCRL) together with receptor activity-modifying protein 1 (RAMP1), as described in 1998. CGRP release from trigeminal neurons is studied in migraine models and in neurogenic vasodilation. Olcegepant, telcagepant, MK-3207 and ubrogepant are small-molecule antagonists of this receptor complex. CGRP 8-37 (human) is a truncated peptide antagonist, and α-CGRP(human) serves as the native agonist.

5 Items

  • Eloralintide
    Cat. No.
    A58864

    Eloralintide

    Synonyms: LY-3841136

    Eloralintide is an amylin receptor (AMYR) activator designed for long-lasting metabolic effects. This peptide selectively targets amylin receptors while minimizing activation of calcitonin receptors, thanks to its unique C20 fatty diacid modification. Eloralintide has been shown to decrease appetite and contribute to weight reduction, making it a valuable tool for research into obesity and related metabolic disorders.

    1 mg
    $190.00
    5 mg
    $490.00
    All 6 sizes
  • (R)-CTR/AMYR activator-1
    Cat. No.
    A58887

    (R)-CTR/AMYR activator-1

    (R)-CTR/AMYR activator-1 is a potent CTR/AMYR activator with EC50 values of 0.8 nM and 0.73 nM. This compound plays a significant role in the regulation of blood glucose levels and bone metabolism. It is useful in researching metabolic disorders and bone health, providing insights into potential therapeutic targets for related diseases.

    Out of stock

    All 3 sizes
  • CTR/AMYR activator-1
    Cat. No.
    A58892

    CTR/AMYR activator-1

    CTR/AMYR activator-1 is a potent activator of the CTR and AMYR pathways. This compound plays a significant role in modulating physiological processes related to bone health, metabolism, cardiovascular function, and neurodegeneration. It is a valuable tool for researchers investigating the underlying mechanisms of these diseases and for potential therapeutic development.

    Out of stock

    All 3 sizes
  • Adrenomedullin (1-50), rat
    Cat. No.
    A59614

    Adrenomedullin (1-50), rat

    Synonyms: Adrenomedullin (rat)

    Adrenomedullin (1-50), rat is a 50 amino acid peptide that functions as a CGRP receptor activator. It is known to induce selective arterial vasodilation, making it relevant for research in cardiovascular physiology and pathophysiology. This peptide is utilized in studies investigating the role of adrenomedullin in vascular regulation and its potential therapeutic applications in hypertension and related disorders.

    0.5 mg
    $200.00
    1 mg
    $280.00
    All 3 sizes
  • Calcitonin Gene Related Peptide II (rat)
    Cat. No.
    A59629

    Calcitonin Gene Related Peptide II (rat)

    Synonyms: CGRP II (rat)

    Calcitonin Gene Related Peptide II (rat) is a CGRP receptor activator that functions as a potent and enduring vasodilator. It plays a crucial role in the regulation of vascular tone and blood pressure. This peptide is utilized in research on cardiovascular diseases, aiding in the exploration of therapeutic strategies for conditions such as hypertension and vascular dysfunction.

    Out of stock

    All 3 sizes

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