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Parathyroid Hormone Receptor (PTH1R)

PTH1R agonists and peptides act on the parathyroid hormone 1 receptor in bone and kidney. Parathyroid hormone 1 receptor (PTH1R) is a class B G protein-coupled receptor (GPCR) that binds parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHrP). A single receptor for both ligands was cloned in 1991. PTH1R signaling controls calcium and phosphate balance, and a 1996 mouse study linked PTHrP signaling through the receptor to Indian hedgehog-regulated bone growth. Most products here are peptides, such as teriparatide acetate hydrate and Human PTHrP-(1-36). pTH (39-84) (human) is a C-terminal fragment of the hormone. CH5447240 is listed as a small-molecule agonist of the same receptor.

2 Items

  • pTH-Related Protein (1-40) (human, mouse, rat)
    Cat. No.
    A46206
    CAS No.
    120298-73-9

    pTH-Related Protein (1-40) (human, mouse, rat)

    pTH-Related Protein (1-40) is an activator of the parathyroid hormone receptor (PTHR) and protein kinase C isoforms α and β. This peptide enhances calcium uptake in rat intestinal cells by stimulating the PTHR1 receptor, leading to the upregulation of critical calcium transport proteins, including TRPV6, CaBP-D9k, NCX1, and PMCA1. Its biological activity makes it a valuable tool for research focused on calcium signaling and endocrine regulation in both human and animal models.

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  • Octadecyl β-D-glucopyranosiduronic acid
    Cat. No.
    A63523
    CAS No.
    1413439-62-9

    Octadecyl β-D-glucopyranosiduronic acid

    Octadecyl β-D-glucopyranosiduronic acid is an activator of the parathyroid hormone 1 receptor (PTH1R), exhibiting a pEC50 value greater than 9. This compound plays a significant role in advancing research in hypoparathyroidism, facilitating studies aimed at understanding receptor activation and its physiological implications. Its ability to modulate PTH1R signaling can provide critical insights into therapeutic approaches for disorders related to calcium homeostasis.

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