LPA Receptor

LPA receptor antagonists and agonists act on receptors for the lipid mediator lysophosphatidic acid (LPA). Six LPA receptors, LPA1 to LPA6, are known, and all belong to the G protein-coupled receptor family. The first, LPA1, was identified in 1996 as the product of ventricular zone gene-1 in the developing cerebral cortex. LPA signaling controls cell migration, proliferation and cytoskeletal change in many tissues. In 2008 LPA1 was linked to fibroblast recruitment and vascular leak in a model of pulmonary fibrosis. Ki16425 and Ki16198 block LPA1 and LPA3, and AM966, AM095 and ONO-7300243 are LPA1 antagonists. GRI 977143 and Radioprotectin-1 act as LPA2 agonists, while AS2717638 antagonizes LPA5.

3 Items

  • 1-Oleoyl lysophosphatidic acid sodium
    Cat. No.
    A24660

    1-Oleoyl lysophosphatidic acid sodium

    Synonyms: 1-Oleoyl-sn-glycero-3-phosphate sodium; 1-Oleoyl-LPA sodium

    1-Oleoyl lysophosphatidic acid sodium is a potent LPA receptor activator, functioning primarily as a bioactive phospholipid. This compound promotes mitosis by inducing DNA synthesis, making it critical for studies in cell proliferation. Additionally, 1-Oleoyl lysophosphatidic acid sodium plays a role in mediating both normal and pathological emotional responses, including anxiety and depression, contributing to research in neurobiology and mental health disorders.

    1 mg
    $25.00
    2 mg
    $40.00
    All 8 sizes
  • 1-Oleoyl lysophosphatidic acid
    Cat. No.
    A61120

    1-Oleoyl lysophosphatidic acid

    Synonyms: 1-Oleoyl-sn-glycero-3-phosphate; 1-Oleoyl-LPA

    1-Oleoyl lysophosphatidic acid is a potent activator of lysophosphatidic acid (LPA) receptors, exhibiting strong biological activity due to its high affinity for these receptors. This compound is frequently utilized in research to investigate LPA receptor signaling pathways and related cellular responses. Additionally, 1-Oleoyl lysophosphatidic acid has been shown to enhance SRE-driven β-galactosidase activity, making it a valuable tool in studies of gene expression and cellular signaling.

    Out of stock

    All 3 sizes
  • AzoLPA ammonium
    Cat. No.
    A61185

    AzoLPA ammonium

    AzoLPA ammonium is a photoswitchable lipid that functions as an activator of the Lysophosphatidic acid receptors 1-5 (LPA1-5). This compound initiates LPA receptor signaling pathways, enabling researchers to investigate the physiological roles of LPA in various biological processes. It is particularly valuable for applications in cell signaling studies and the exploration of LPA-related mechanisms in cancer, neurobiology, and cell migration.

    Out of stock

    All 3 sizes

3 Items

Added to your cart

View Cart Checkout

    Loading...