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Somatostatin Receptors

Somatostatin receptor (SSTR) agonists and antagonists act on SSTR1 to SSTR5, five G protein-coupled receptors. Somatostatin was isolated from hypothalamus in 1973 as a peptide that inhibits growth hormone secretion from the pituitary. Its receptors couple mainly to inhibitory G proteins, lower cyclic adenosine monophosphate (cAMP) and suppress hormone release in the pituitary, pancreas and gut. Human and mouse somatostatin receptors were cloned in 1992 and found in brain, gastrointestinal tract and kidney. The natural peptide is listed together with cyclic somatostatin, octreotide acetate and pasireotide L-aspartate salt, stable analogs with different subtype profiles. Subtype tools include the SSTR2 antagonist CYN-154806, the SSTR4 agonist J-2156, and SSTR5 antagonist 1 and SSTR5 antagonist 2.

2 Items

  • Reltecimod
    Cat. No.
    A48014
    CAS No.
    1447799-33-8

    Reltecimod

    Synonyms: AB-103

    Reltecimod is a somatostatin receptor activator that modulates the immune response by targeting the CD28/B7-2 co-stimulatory pathway. This compound exhibits protective effects against various bacterial infections, their toxins, and ionizing radiation. Reltecimod is particularly relevant for research into necrotizing soft-tissue infections (NSTIs), providing insights into therapeutic interventions and immune modulation.

    In stock View Details
    5 mg
    $35.00
    10 mg
    $55.00
    All 3 sizes
  • Veldoreotide
    Cat. No.
    A63867
    CAS No.
    252845-37-7

    Veldoreotide

    Synonyms: DG3173; PTR-3173

    Veldoreotide is a somatostatin receptor activator that selectively binds to and activates somatostatin receptors 2, 4, and 5. This compound effectively inhibits growth hormone secretion in adenomas, presenting a potential advantage over other somatostatin analogues. Additionally, Veldoreotide may serve as a pain modulating agent, making it relevant for research in endocrine disorders and pain management strategies.

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    Out of stock

    All 3 sizes

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