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Formyl Peptide Receptor (FPR)

FPR agonists and antagonists act on formyl peptide receptors (FPRs) of innate immune cells. Humans express three of these G protein-coupled receptors, FPR1, FPR2 and FPR3, and FPR2 is also known as the lipoxin A4 receptor (ALX) because it binds this lipid mediator. FPR1 recognizes N-formylated peptides released by bacteria and damaged mitochondria and directs neutrophil chemotaxis and activation. FPR2 binds a wider range of peptide and lipid ligands and is studied in the resolution of inflammation. HCH6-1 and cyclosporin H are FPR1 antagonists, whereas ACT-389949, BMS-986235 and BMS-986331 activate FPR2. The synthetic hexapeptide WKYMVm TFA and FPR Agonist 43 stimulate both FPR1 and FPR2.

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  • SHAAGtide
    Cat. No.
    A60323
    CAS No.
    510732-22-6

    SHAAGtide

    SHAAGtide is an activator of the formyl peptide receptor-like 1 (FPRL1). This compound exhibits anti-inflammatory activity by modulating the immune response through FPR2, effectively reducing the expression of inflammatory cytokines in murine models. SHAAGtide is valuable for research investigating conditions such as lung inflammation and fibrosis, facilitating a deeper understanding of inflammatory pathways and potential therapeutic interventions.

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