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Neuropeptide FF Receptor

Neuropeptide FF receptor ligands act on two peptide receptors that modulate pain and opioid responses. Neuropeptide FF (NPFF) and related peptides end in an Arg-Phe-amide (RFamide) motif. Two G protein-coupled receptors for NPFF, NPFF1 and NPFF2, were identified in 2000. NPFF binds both receptors with nanomolar affinity, slightly more tightly to NPFF2. The system is studied in pain processing, opioid tolerance and hormone regulation. RF9, reported in 2006 as a selective NPFF receptor antagonist, prevented opioid-induced hyperalgesia and tolerance in rodents. The category lists Neuropeptide FF, RFRP-3(human) and Neuropeptide AF (cattle), the NPFF2 activator AC-263093 free base and the antagonists RF9 and DP32.

2 Items

  • Neuropeptide AF (cattle)
    Cat. No.
    A61585
    CAS No.
    99588-52-0

    Neuropeptide AF (cattle)

    Neuropeptide AF (cattle) is an amidated octadecapeptide that targets RFamide neuropeptide receptors. It serves as a ligand for Mas-related gene receptor A4 (MrgprA4) with an EC50 of approximately 60 nM and MrgprC11 with an EC50 around 300 nM. Additionally, it activates the G protein-coupled receptors NPFF1 and NPFF2, exhibiting EC50 values ranging from 25-325 nM and 1-5 nM, respectively. Neuropeptide AF (cattle) demonstrates anti-opiate properties and plays a significant role in pain modulation research applications.

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  • AC-263093 free base
    Cat. No.
    A62167
    CAS No.
    849459-86-5

    AC-263093 free base

    Synonyms: AC-093

    AC-263093 free base is an activator of the neuropeptide FF receptor 2 (NPFFR2), exerting functional activation while inhibiting NPFF receptor 1 (NPFFR1), with pKi values of 6.9 and 7.0, respectively. This compound holds potential in the investigation of mechanisms to reverse opioid tolerance, making it valuable for research related to pain management and neuropharmacology.

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    5 mg
    $35.00
    10 mg
    $55.00
    All 5 sizes

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