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Adenylyl Cyclase

Adenylyl cyclase activators and inhibitors act on the enzymes that make a central second messenger. Each catalytic cycle turns adenosine triphosphate (ATP) into cyclic adenosine monophosphate (cAMP) and releases pyrophosphate. Mammals have nine membrane-bound isoforms (AC1 to AC9), regulated by G proteins, and one soluble adenylyl cyclase (sAC). Forskolin, a plant diterpene, was shown in 1981 to activate the enzyme directly, and NKH477 is a water-soluble derivative. The soluble enzyme, described as a cytosolic form in 1999, responds to bicarbonate and calcium rather than to G proteins. LRE1, reported in 2016 as an allosteric inhibitor, and KH7 both block sAC selectively. ST034307 is listed as an AC1 inhibitor, and 2',5'-dideoxyadenosine acts as a broad P-site inhibitor.

2 Items

  • L 858051 dihydrochloride
    Cat. No.
    A58095
    CAS No.
    115116-37-5

    L 858051 dihydrochloride

    Synonyms: 7DMB-Forskolin

    L 858051 dihydrochloride is a potent adenylyl cyclase activator that directly stimulates the production of cyclic AMP (cAMP) in cells. This compound significantly elevates intracellular cAMP levels, inducing robust activation of recombinant cyclic nucleotide-gated channels and enhancing L-type Ca2+ currents in adult rat ventricular myocytes. Additionally, it has been shown to increase total phosphodiesterase activities, providing valuable insights into subsarcolemmal cAMP dynamics and compartmentation within cardiac cells. L 858051 dihydrochloride is a useful reagent for exploring cAMP-related signaling pathways in cardiovascular research.

    In stock View Details
    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes
  • L 858051
    Cat. No.
    A58096
    CAS No.
    110452-75-0

    L 858051

    Synonyms: 7DMB-Forskolin free base

    L 858051 is an adenylyl cyclase stimulator that enhances intracellular cAMP levels through direct activation of adenylyl cyclase. This compound effectively induces non-selective, Mg2+-sensitive currents in recombinant cyclic nucleotide-gated channels and maximally stimulates L-type Ca2+ currents in adult rat ventricular myocytes. Additionally, L 858051 increases total PDE3 and PDE4 activities in these cells, demonstrating effects that are not influenced by PKA inhibition. It is a valuable tool for investigating subsarcolemmal cAMP dynamics and compartmentation in cardiac myocytes.

    In stock View Details
    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes

2 Items

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