Adenosine Receptors

Cat. No.

A57879

CAS No.

130-49-4

Adenosine-2'-monophosphate

Synonyms: 2'-AMP; Adenosine 2'-phosphate; AMP 2'-phosphate

Adenosine-2'-monophosphate (2'-AMP) functions primarily as an adenosine receptor activator. This compound is metabolized to extracellular adenosine through the extracellular 2’,3’-cAMP-adenosine pathway, playing a crucial role in modulating immune responses. Research indicates that 2'-AMP inhibits lipopolysaccharide (LPS)-induced production of TNF-α and CXCL10 via activation of the A2A receptor, making it a valuable tool in studies of inflammation and immune regulation.

Cat. No.

A57914

CAS No.

40312-34-3

Adenosine A1 receptor activator T62

Adenosine A1 receptor activator T62 is an allosteric enhancer of the adenosine A1 receptor. It exhibits significant antinociceptive properties in animal models of acute pain and effectively alleviates hypersensitivity in models of inflammatory and nerve-injury pain. This compound is valuable for research focused on pain management and the modulation of pain pathways.

Cat. No.

A57996

CAS No.

3032475-38-7

A3AR agonist 5

A3AR Agonist 5 is a potent activator of the A3 adenosine receptor (A3AR), exhibiting EC50 and Ki values of 0.14 nM and 6.36 nM for cAMP and human A3 receptors, respectively. This compound is valuable for research into pain modulation and inflammation, making it a significant tool for studies examining adenosine receptor signaling pathways and their therapeutic implications.