Guanylate Cyclase

Cat. No.

A11549

CAS No.

625115-55-1

Riociguat (BAY 63-2521)

Synonyms: BAY 63-2521

Riociguat (BAY 63-2521; BAY 632521) is a stimulator of soluble guanylate cyclase (sGC).

Cat. No.

A12402

CAS No.

170632-47-0

YC-1 (Lificiguat)

Synonyms: Lificiguat

YC-1 is a direct activator of soluble Guanylyl Cyclase (sGC), independent of Nitric Oxide.

Cat. No.

A13355

CAS No.

137213-91-3

(4-Acetamidocyclohexyl) nitrate

Synonyms: BM121307

(4-Acetamidocyclohexyl) nitrate (BM121307) is a guanylate cyclase activator that was in phase I development for the treatment of ischaemic heart disorders. The research has been discontinued.

Cat. No.

A13670

CAS No.

1628732-62-6

Olinciguat

Synonyms: IW-1701

Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay.

Cat. No.

A15891

CAS No.

256376-24-6

BAY 41-2272

BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.

Cat. No.

A19315

CAS No.

1628730-49-3

Praliciguat

Synonyms: IW-1973

Praliciguat (IW-1973) is a potent and orally active soluble guanylate cyclase stimulator, enhances NO signaling, acts as a vasodilator. Praliciguat (IW-1973) stimulates sGC in HEK-293 cells with an EC50 of 197 nM.

Cat. No.

A20200

CAS No.

1402936-61-1

Runcaciguat

Runcaciguat is an orally active stimulator of soluble guanylate cyclase, and is used in the research of cardiovascular and renal diseases combined with selective partial adenosine A1 receptor agonists.

Cat. No.

A20591

CAS No.

625115-52-8

Nelociguat

Synonyms: BAY60-4552

Nelociguat (BAY60-4552) is a nitric oxide sensitive soluble guanylate cyclase stimulator.

Cat. No.

A21031

CAS No.

1350653-20-1

Vericiguat

Synonyms: BAY1021189

Vericiguat (BAY1021189) is a potent, orally available and soluble guanylate cyclase stimulator.

Cat. No.

A21283

CAS No.

329773-35-5

Cinaciguat

Cinaciguat is an activator of guanylate cyclase (sGC), and used for acute decompensated heart failure.

Cat. No.

A21838

CAS No.

646995-35-9

Cinaciguat hydrochloride

Synonyms: BAY 58-2667 hydrochloride; BAY-58-2667

Cinaciguat hydrochloride is a potent soluble guanylate cyclase (GC) activator with EC50 of 15 nM in platelets.

Cat. No.

A35846

CAS No.

2201048-82-8

Zagociguat

Synonyms: CY-6463; IW-6463

Zagociguat is a soluble guanylate cyclase (sGC) stimulator that is orally active and penetrates the blood-brain barrier. This compound enhances intracellular levels of cGMP, leading to regulation of blood pressure, improved neuronal function, reduced inflammatory responses, and neuroprotective effects. Zagociguat is primarily utilized in research focused on neurodegenerative diseases.

Cat. No.

A60859

CAS No.

1027642-43-8

BAY 60-2770

BAY 60-2770 is a selective and orally active soluble guanylyl cyclase (sGC) activator that enhances sGC activity independent of nitric oxide. This compound exhibits significant antifibrotic properties, making it a valuable tool for research into fibrosis and related diseases. Its unique mechanism of action allows for exploration in various biological pathways associated with cardiovascular and respiratory health.

Cat. No.

A60863

CAS No.

254877-67-3

Ataciguat

Synonyms: HMR-1766

Ataciguat is a soluble guanylate cyclase (sGC) activator that functions independently of nitric oxide. It specifically activates the ferric heme-iron redox form of sGC, leading to increased production of cyclic GMP (cGMP). This compound demonstrates significant vasodilatory effects and is useful in research applications related to cardiovascular function and regulation of vascular tone.

Cat. No.

A60869

CAS No.

256498-66-5

BAY 41-8543

BAY 41-8543 is a soluble guanylyl cyclase (sGC) stimulator that functions independently of nitric oxide (NO). It exhibits vasodilatory effects in both pulmonary and systemic vascular beds in rat models. Additionally, BAY 41-8543 demonstrates antiplatelet activity, making it a valuable tool for research in cardiovascular diseases.

Cat. No.

A60871

CAS No.

112199-06-1

Prepro-ANF (56-92), human

Prepro-ANF (56-92), human is a precursor of the atrial natriuretic factor and functions as a guanylate cyclase activator. This peptide enhances the activity of particulate guanylate cyclase within renal membranes and units, playing a critical role in the regulation of renal function and blood pressure homeostasis. Its application in research includes studies on cardiovascular and renal physiology, as well as investigations into natriuretic signaling pathways.

Cat. No.

A60873

CAS No.

1852495-86-3

(Rac)-MGV354

(Rac)-MGV354 is a potent soluble guanylate cyclase (sGC) activator, exhibiting EC50 values of less than 0.5 nM in CHO cells and 5 nM in GTM-3 E cells. Its ability to stimulate sGC makes it a valuable tool for investigating nitric oxide signaling pathways and their role in various biological processes. This compound is suitable for research applications focused on cardiovascular function and related signaling mechanisms.

Cat. No.

A60874

CAS No.

183200-12-6

Guanylin(human)

Guanylin (human) is a 15-amino acid peptide that functions as an activator of intestinal guanylate cyclase. It primarily regulates electrolyte and water transport in intestinal and renal epithelia via a cyclic GMP-dependent mechanism. This endogenous peptide plays a crucial role in maintaining fluid homeostasis and is vital in studies related to gastrointestinal function and renal physiology. Research applications include investigating gastrointestinal disorders and kidney function modulation.

Cat. No.

A60875

CAS No.

1609342-18-8

BAY-747

Synonyms: BAY 1165747

BAY-747 is a soluble guanylate cyclase (sGC) stimulator that exhibits potent oral bioactivity and brain penetrance. It has been shown to reverse L-NAME-induced memory impairments, thereby enhancing cognitive performance in rats during the object location task (OLT). Additionally, BAY-747 effectively reduces blood pressure in both normotensive and spontaneously hypertensive rat models. Furthermore, it demonstrates therapeutic potential by improving skeletal muscle function in the Duchenne muscular dystrophy (DMD) mdx/mTRG2 mouse model, making it a valuable reagent for neurological and cardiovascular research.

Cat. No.

A60876

CAS No.

1215548-30-3

CFM 1571 hydrochloride

CFM 1571 hydrochloride is a potent stimulator of soluble guanylate cyclase (sGC), with an EC50 of 5.49 μM and an IC50 of 2.84 μM. This enzyme plays a critical role in the signaling pathway activated by nitric oxide (NO), which is essential for various physiological processes. CFM 1571 hydrochloride is valuable for research investigating cardiovascular conditions and other diseases linked to sGC signaling.

Cat. No.

A60878

CAS No.

2231749-54-3

Mosliciguat

Synonyms: BAY 1237592

Mosliciguat is a potent guanylate cyclase activator that enhances nitric oxide signaling through the stimulation of soluble guanylate cyclase. This compound exhibits key biological activities, including vasodilation and reduced blood pressure, making it relevant for cardiovascular research. Mosliciguat is primarily utilized in studies assessing pulmonary hypertension and related disorders, providing valuable insights into endothelial function and smooth muscle relaxation.

Cat. No.

A60879

CAS No.

2740807-77-4

BI 703704

BI 703704 is a potent soluble guanylate cyclase (sGC) activator that enhances intracellular signaling pathways through increased cGMP levels. It has demonstrated efficacy in inhibiting the progression of diabetic nephropathy in the ZSF1 rat model, making it a valuable tool for studying renal complications associated with diabetes. This compound is useful for research on cardiovascular and metabolic diseases, particularly those involving sGC modulation.

Cat. No.

A60880

CAS No.

1579514-06-9

Avenciguat

Synonyms: BI-685509

Avenciguat is a potent and orally active soluble guanylate cyclase (sGC) activator. By enhancing the production of cyclic guanosine monophosphate (cGMP), Avenciguat effectively improves nitric oxide (NO) signaling pathways. This compound is valuable for research on chronic kidney disease (CKD) and diabetic kidney disease (DKD), offering insights into therapeutic mechanisms and potential treatment strategies.

Cat. No.

A60881

CAS No.

1423067-48-4

(Rac)-BI 703704

(Rac)-BI 703704 is a potent activator of soluble guanylyl cyclase (sGC). This compound has demonstrated the ability to mitigate renal damage progression in the ZSF1 rat model, suggesting its potential therapeutic application in diabetic nephropathy. The modulation of sGC activity may offer novel insights into the treatment of related renal disorders.

Cat. No.

A60884

CAS No.

2101645-33-2

sGC activator 1

sGC activator 1 is a potent activator of soluble guanylate cyclase (sGC), a key enzyme involved in the nitric oxide signaling pathway. By enhancing sGC activity, this compound increases intracellular levels of cyclic guanosine monophosphate (cGMP), leading to various biological effects such as vasodilation and smooth muscle relaxation. sGC activator 1 is utilized in research applications focused on cardiovascular diseases, neuroprotection, and cellular signaling mechanisms.