CDK

Cat. No.

A10163

CAS No.

1092443-52-1

BS-181

BS-181 is a potential anti-tumor agent as CDK7 inhibitor.

Cat. No.

A10471

CAS No.

479-41-4

Indirubin

Synonyms: Couroupitine B; Indigo red

Indirubin, the active constituent of a Chinese antileukaemia medicine, is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 μM and 0.6 μM.

Cat. No.

A10850

CAS No.

345627-80-7

SNS-032 (BMS-387032)

Synonyms: BMS-387032

SNS-032 (BMS-387032) is a highly selective and potent inhibitor of cyclin-dependent kinases (Cdks) 2, 7, and 9, with in vitro growth inhibitory effects and ability to induce apoptosis in malignant B cells.

Cat. No.

A11045

CAS No.

131740-09-5

Flavopiridol HCl

Flavopiridol HCl is an inhibitor of cyclin-dependent kinases. The (-)-cis form induces apoptosis in particular tumor cells.

Cat. No.

A11047

CAS No.

802539-81-7

Milciclib (PHA-848125)

Synonyms: PHA848125

PHA-848125 (Milciclib) is an orally bioavailable inhibitor of CDKs and TRKA with potential antineoplastic activity.

Cat. No.

A11105

CAS No.

602306-29-6

AZD5438

AZD5438 is a potent inhibitor of cyclin-dependent kinase (CDK) 1, 2 and 9 (IC50 values are 16, 6 and 20 nM respectively).

Cat. No.

A11154

CAS No.

582315-72-8

BMS-265246

BMS-265246 is a potent new pyra- zolopyridine inhibitor of cdk2/cyclin E and cdk1/cyclin B, as well as cdk4/cyclin D.

Cat. No.

A11190

CAS No.

741713-40-6

R547

R547 is a novel, selective inhibitor of cell cycle and transcriptional cyclin dependent kinases (CDKs) (Ki = 1, 3, and 1 nM for CDK1, CDK2, and CDK4, respectively) with excellent in vitro cellular potency that inhibits the growth of various human tumor cell lines.

Cat. No.

A11313

CAS No.

902135-91-5

AT7519 HCl

Synonyms: AT 7519

AT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation.

Cat. No.

A11347

CAS No.

164658-13-3

CGP60474

CGP60474 is a potent inhibitor of cyclin-dependent kinase (CDK).

Cat. No.

A11353

CAS No.

1269815-17-9

CDK-IN-2

Synonyms: CDK inhibitor II

CDK-IN-2 is a potent and specific CDK9 inhibitor with IC50 of

Cat. No.

A11962

CAS No.

937270-47-8

(E/Z)-Zotiraciclib ((E/Z)-TG-02, (E/Z)-SB1317)

Synonyms: TG 02; SB1317; (E/Z)-TG-02; (E/Z)-SB1317

TG-02 is a novel small molecule potent CDK/JAK2/FLT3 inhibitor.

Cat. No.

A12100

CAS No.

82508-32-5

Pseudolaric Acid A

Pseudolaric Acid A is a diterpene acid isolated from Pseudolarix kaempferi, has antifungal, cytotoxic and antifertile activities.

Cat. No.

A12186

CAS No.

1402821-24-2

Ca2+ channel agonist 1

Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2, with EC50s of 14.23 μM and 3.34 μM, respectively, and is used as a potential treatment for motor nerve terminal dysfunction.

Cat. No.

A12352

CAS No.

212844-54-7

Purvalanol B

Synonyms: NG 95

Purvalanol B is a cyclin-dependent kinase inhibitor. IC50 values are 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Selective over a range of other protein kinases (IC50 > 10,000 nM).

Cat. No.

A12438

CAS No.

444722-95-6

NU 6102

NU6102 is selective for CDK1 and CDK2 compared to CDK4/D1 (IC50=1.6 μM), DYRK1A (IC50=0.9 μM), PDK1 (IC50=0.8 μM) and ROCKII (IC50=0.6 μM).

Cat. No.

A12494

CAS No.

212779-48-1

NG52

Synonyms: Compound 52

NG52 is a potent, cell-permeable, reversible, selective, and ATP-compatible inhibitor of the cell cycle-regulating kinase, Cdc28p (IC50 = 7 _mu_M), and the related Pho85p kinase (IC50 = 2 _mu_M).

Cat. No.

A12513

CAS No.

1402055-25-7

Cdc7-IN-1

Cdc7-IN-1 (Compound 13) is a highly potent, selective and ATP competitive inhibitor of Cdc7 kinase, with an IC50 value of 0.6 nM at 1 mM ATP and with slow off-rate characteristics.

Cat. No.

A12584

CAS No.

1357470-29-1

ON123300

ON123300 is a potent multikinase inhibitor and may be potential useful for brain tumor chemotherapy. ON123300 strongly inhibits Ark5 and CDK4, as well as growth factor receptor tyrosine kinases such as ??-type platelet-derived growth factor receptor (PDGFRβ).

Cat. No.

A12644

CAS No.

1883423-59-3

MSC2530818

MSC2530818 is a potent, selective and orally available CDK8 inhibitor with an IC50 of 2.6 nM for CDK8.

Cat. No.

A12961

CAS No.

1629633-48-2

CDK8-IN-1

CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM.

Cat. No.

A13130

CAS No.

784210-87-3

RGB-286638

RGB-286638 is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 and cyclin D3-CDK6.

Cat. No.

A13454

CAS No.

1204918-72-8

Zotiraciclib (SB1317, TG02)

Synonyms: SB1317; TG02

SB1317 is a potent inhibitor of Cyclin dependent kinases (CDKs), FMS-like tyrosine kinase-3 (FLT3) and Janus kinase 2 (JAK2) with IC50 values of 13nM, 56nM and 73nM for CDK2, JAK2 and FLT3, respectively.

Cat. No.

A13506

CAS No.

924641-59-8

AZD5597

AZD5597 is potent CDK inhibitor with in vitro anti-proliferative effects against a range of cancer cell lines.

Cat. No.

A13524

CAS No.

383907-43-5

NSC 663284

Synonyms: SPS8I; DA-3003-1; Cdc25 Phosphatase Inhibitor II

NSC 663284 is a potent, cell-permeable, and irreversible inhibitor of all Cdc25 isoforms, with preference for Cdc25A (IC50 = 29, 95, and 89 nM for Cdc25A, Cdc25B2, and Cdc25C, respectively).