AChE

Cat. No.

A78785

CAS No.

2653349-51-8

S16–1029

S16–1029 is a selective and orally active butyrylcholinesterase (BChE) inhibitor, exhibiting IC50 values of 11.35 nM for equine BChE and 48.1 nM for human BChE. This compound is capable of crossing the blood-brain barrier (BBB), enabling it to effectively target the central nervous system (CNS). S16–1029 serves as a valuable tool for research in Alzheimer's disease (AD), contributing to the understanding of cholinergic dysfunction in neurodegenerative conditions.

Cat. No.

A78786

CAS No.

2700896-78-0

BChE-IN-14

BChE-IN-14 is a selective butyrylcholinesterase (BChE) inhibitor, demonstrating IC50 values of 0.23 μM for equine BChE and 0.011 μM for human BChE. This compound exhibits favorable blood-brain barrier permeability and primary cell safety, making it suitable for in vivo studies. BChE-IN-14 has potential in restoring cognitive function, positioning it as a valuable tool for research into Alzheimer’s disease and related neurodegenerative conditions.

Cat. No.

A78788

CAS No.

154-97-2

Pralidoxime methanesulfonate

Pralidoxime methanesulfonate is a potent reactivator of acetylcholinesterase (AChE) that functions through direct nucleophilic attack by the oxime moiety on the phosphorus center of organophosphate-bound AChE. This reagent effectively restores AChE activity inhibited by nerve agents, making it critical in therapeutic interventions for organophosphate poisoning. Its primary applications include research into nerve agent effects and developing antidotes for chemical warfare agents.

Cat. No.

A78789

CAS No.

180694-97-7

Mimopezil

Synonyms: ZT-1

Mimopezil is a cholinesterase (ChE) inhibitor that converts to the active metabolite Huperzine A in aqueous conditions. This compound demonstrates significant biological activity by enhancing acetylcholine levels, which is relevant in research focused on neurodegenerative diseases. Although Mimopezil exhibits low bioavailability in vivo, its effective metabolism to Huperzine A leads to increased concentrations in the bloodstream, making it a valuable tool for studying cognitive function and synaptic transmission.

Cat. No.

A78790

CAS No.

126594-75-0

(3β,5α,6α,16β)-8,14-Didehydrocevane-3,6,16,20-tetrol

(3β,5α,6α,16β)-8,14-Didehydrocevane-3,6,16,20-tetrol is an acetylcholinesterase (AChE) inhibitor. At a concentration of 100 μg/mL, this compound demonstrates an in vitro inhibition rate of 12% against AChE, highlighting its potential utility in studies related to neurodegenerative diseases and cognitive disorders. Its application in biochemical research may provide insights into AChE-related pathways and therapeutic targets.

Cat. No.

A78791

CAS No.

1607436-76-9

Monardic acid A

Monardic acid A is a selective inhibitor of acetylcholinesterase (AChE), exhibiting an IC50 of 53.1 μM against AChE from electric eel. It displays weak inhibitory activity against human erythrocyte AChE (IC50 >100 μM) and negligible effects on butyrylcholinesterase (BChE). By inhibiting AChE activity, Monardic acid A effectively reduces acetylcholine breakdown, contributing to its anti-inflammatory properties and modulation of neurotransmitter release. This compound is sourced from lungwort (Pulmonaria officinalis) and thyme (Thymus gobicus), making it valuable for research in anti-inflammatory drug development and neurodegenerative disease therapeutics.

Cat. No.

A78792

CAS No.

2662756-69-4

Isoprocarb-d3

Isoprocarb-d3 is a deuterated form of Isoprocarb, a carbamate insecticide known for its efficacy in controlling pests such as rice paddy lice and leafhoppers. As an inhibitor of cholinesterase (ChE), Isoprocarb-d3 serves as a valuable tool in researching the mechanisms of action of carbamate insecticides and the effects of ChE inhibition. This compound can be utilized in studies related to pest management, neurobiology, and toxicology.

Cat. No.

A78793

CAS No.

1679-76-1

Drofenine

Synonyms: Cycloadiphene; Hexahydroadiphenine

Drofenine is a potent competitive inhibitor of cholinesterase (ChE), with a Ki value of 3 μM. This compound effectively inhibits the breakdown of acetylcholine, leading to increased levels of this important neurotransmitter. Drofenine is utilized in research to study cholinergic signaling and its implications in neurodegenerative diseases, as well as to explore potential therapeutic avenues for conditions associated with impaired cholinergic transmission.

Cat. No.

A78795

CAS No.

1219798-88-5

Donepezil-d4 hydrochloride

Synonyms: E2020-d4

Donepezil-d4 hydrochloride is a deuterium-labeled derivative of Donepezil hydrochloride, a reversible and selective inhibitor of acetylcholinesterase (AChE) with an IC50 of 6.7 nM. This compound demonstrates a strong selectivity for AChE over butyrylcholinesterase (BuChE) and exhibits neuroprotective effects against Aβ42-induced neurotoxicity. Donepezil-d4 is valuable for studying AChE interactions and pharmacokinetics in neurodegenerative disease research.

Cat. No.

A78796

CAS No.

2020357-32-6

BChE-IN-23

BChE-IN-23 is a potent butyrylcholinesterase (BChE) inhibitor with an IC50 value of 21 nM. This compound is particularly valuable in Alzheimer's disease research, facilitating the study of cholinergic dysfunction associated with neurodegenerative conditions. Its selective inhibition of BChE may contribute to the development of therapeutic strategies for cognitive impairments in Alzheimer's disease.

Cat. No.

A78797

CAS No.

2499490-52-5

BuChE-IN-4

BuChE-IN-4 is a selective butyrylcholinesterase (BuChE) inhibitor with an IC50 of 7.7 nM. It demonstrates mild antioxidant properties and neuroprotective effects while exhibiting a favorable lipophilicity and low toxicity profile. This compound is applicable in research focused on neurodegenerative diseases and exploring cholinergic signaling pathways.

Cat. No.

A78798

CAS No.

3811-49-2

Salithion

Synonyms: Dioxabenzofos

Salithion is an acetylcholinesterase inhibitor that disrupts the hydrolysis of acetylcholine by binding to the enzyme's active site. This compound exhibits enantioselectivity, with distinct differences in the biological activity of its (R) and (S) enantiomers. Salithion serves as a valuable tool in neurotoxicology research and studies related to cholinergic signaling pathways.

Cat. No.

A78799

CAS No.

2713548-95-7

AChE-IN-3

AChE-IN-3 is a cholinesterase (ChE) inhibitor that demonstrates moderate inhibitory activity against acetylcholinesterase (AChE). Additionally, it exhibits strong nitric oxide (NO) inhibitory activity with an EC50 of 0.57 μM. This compound is suitable for research applications focused on neurodegenerative diseases and signaling pathways involving nitric oxide.

Cat. No.

A78800

CAS No.

113027-75-1

AChE-IN-103

AChE-IN-103 is a potent acetylcholinesterase (AChE) inhibitor that demonstrates log IC50 values of 1.477 and 2.2 in alignment models I and II, respectively. This compound plays a significant role in the research of Alzheimer’s disease, where it may help elucidate the mechanisms of cholinergic dysfunction. AChE-IN-103 is valuable for studies aimed at developing therapeutic strategies targeting cognitive decline associated with this neurodegenerative disorder.

Cat. No.

A78801

CAS No.

30426-66-5

Pseudocoptisine acetate

Synonyms: Isocoptisine acetate

Pseudocoptisine acetate is a quaternary alkaloid derived from the benzylisoquinoline scaffold, isolated from Corydalis Tuber. It functions as an acetylcholinesterase (AChE) inhibitor, exhibiting an IC50 of 12.8 μM. This compound demonstrates significant anti-inflammatory and anti-amnestic properties, making it valuable for research in neurodegenerative diseases and cognitive impairment studies.

Cat. No.

A78802

CAS No.

129297-21-8

SM 10888

SM 10888 is a selective and orally active cholinesterase (ChE) inhibitor. By enhancing the release of acetylcholine in the brain, SM 10888 offers potential therapeutic benefits in the context of neurological disorders. This compound is particularly relevant for research focused on Alzheimer's disease and other cholinergic dysfunctions.

Cat. No.

A78803

CAS No.

2215768-12-8

BChE-IN-34

BChE-IN-34 is a highly selective inhibitor of butyrylcholinesterase (BChE) with an IIC50 of 25 nM, demonstrating excellent selectivity over acetylcholinesterase. This compound exhibits neuroprotective and antioxidant properties, making it a valuable tool for research into neurodegenerative diseases and cholinergic signaling pathways. Its specificity and efficacy position BChE-IN-34 as a promising candidate for studying the therapeutic potential of targeting BChE in various biological contexts.

Cat. No.

A78804

CAS No.

138472-18-1

Stacofylline hydrochloride

Synonyms: S 9977

Stacofylline hydrochloride is a potent inhibitor of acetylcholinesterase (AChE) with an IC50 range of 5-50 nM. This xanthine derivative exhibits notable anti-amnesic and promnesic effects, making it relevant for research into memory enhancement and cognitive function. Its pharmacological properties position it as a valuable tool in Alzheimer's disease studies and other neurological research applications.

Cat. No.

A78805

CAS No.

61548-34-3

Decaffeoylacteoside

Synonyms: Decaffeoylverbascoside; Verbasoside

Decaffeoylacteoside is an inhibitor targeting acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and lipoxygenase (LOX). This compound exhibits moderate inhibitory activity, making it relevant for research into neurodegenerative diseases and inflammation. Its ability to modulate these enzymes provides potential applications in pharmacological studies aimed at developing therapeutic agents for conditions involving cholinergic dysregulation and oxidative stress.

Cat. No.

A78806

CAS No.

2242792-25-0

AChE-IN-15

AChE-IN-15 is a reversible inhibitor of human acetylcholinesterase (huAChE) with an IC50 value of 6.8 μM and human butyrylcholinesterase (huBChE) with an IC50 value of 16.1 μM. This compound exhibits significant antioxidant activity and has potential applications in research related to Alzheimer's disease. AChE-IN-15 is a valuable tool for investigating cholinesterase inhibition and its role in neurodegeneration.

Cat. No.

A78807

CAS No.

2978753-66-9

AChE-IN-36

AChE-IN-36 is a potent inhibitor of acetylcholinesterase, exhibiting an IC50 of 0.04 μM. This compound influences reactive oxygen species (ROS) levels and modulates the gene expression of NRF2, making it a valuable tool for studies on neurodegenerative diseases and oxidative stress responses. Its activity is relevant for research focused on cholinergic signaling and cellular antioxidant pathways.

Cat. No.

A78808

CAS No.

642-08-0

Ostruthol

Ostruthol is a coumarin compound that functions as a potent inhibitor of acetylcholinesterase (AChE). This inhibition contributes to increased levels of acetylcholine, a neurotransmitter that may be diminished in neurodegenerative disorders. Ostruthol is primarily utilized in Alzheimer's disease research to explore its potential therapeutic effects and mechanisms of action.

Cat. No.

A78809

CAS No.

2428389-65-3

AChE-IN-20

AChE-IN-20 is a potent acetylcholinesterase (AChE) inhibitor, demonstrating an IC50 value of 397.32 nM and a Ki value of 335.76 nM. In addition to its primary target, AChE-IN-20 exhibits significant inhibitory activity against human carbonic anhydrases I and II, and α-glucosidase, with IC50 values of 84.14 nM, 69.24 nM, and 52.08 nM, respectively. This compound is valuable for research into neurodegenerative diseases and enzymatic regulation, providing insights into potential therapeutic strategies.

Cat. No.

A78810

CAS No.

2847856-62-4

2,3,9,10-Tetrahydroxyberberine bromide

2,3,9,10-Tetrahydroxyberberine bromide is a potent acetylcholinesterase (AChE) inhibitor with an IC50 value of 7.8 μM. This compound also demonstrates significant free radical scavenging activity, as evidenced by an IC50 of 43 μM in the DPPH assay. It is particularly relevant for studies focusing on Alzheimer's disease research and the exploration of neuroprotective mechanisms.

Cat. No.

A78811

CAS No.

19638-58-5

(Rac)-Sclerone

Synonyms: 4,5-Dihydroxytetralone; 4-Hydroxy-α-tetralone

(Rac)-Sclerone is an acetylcholinesterase (AChE) inhibitor derived from the green husk of Carya illinoinensis. It demonstrates significant AChE inhibition with an IC50 value of 192.65 ± 10.12 μg/mL. This compound is utilized in research applications targeting Alzheimer's disease and other neurodegenerative disorders, where modulation of cholinergic activity is of interest.