AChE

Cat. No.

A78812

CAS No.

1668-85-5

Epi-galantamine

Epi-galantamine is a diastereomer of galantamine that functions as an acetylcholinesterase (AChE) inhibitor, demonstrating an EC50 of 45.7 μM. This alkaloid is extracted from the bulbs and flowers of Caucasian snowdrop (Galanthus woronowii). Epi-galantamine is notably utilized in research exploring neurodegenerative diseases and cognitive enhancement, contributing to studies on cholinergic signaling and potential therapeutic interventions.

Cat. No.

A78814

CAS No.

3038811-77-4

AChE-IN-41

AChE-IN-41 is a cholinesterase inhibitor designed to enhance acetylcholine levels by preventing its breakdown. This hybrid compound of Galantamine and Memantine demonstrates significant inhibition of cholinesterase activity, offering valuable insights for neurological research. AChE-IN-41 exhibits enhanced plasma stability and similar microsomal stability in vitro, although it possesses a shorter half-life and faster clearance in vivo, making it suitable for studies on cholinergic signaling and potential therapeutic applications in neurodegenerative diseases.

Cat. No.

A78815

CAS No.

2763366-27-2

eeAChE-IN-1

eeAChE-IN-1 is a potent inhibitor of cholinesterase (ChE), exhibiting an IC50 value of 23 nM. This compound is valuable for research applications related to neurodegenerative disorders and the modulation of cholinergic signaling pathways. Its efficacy in inhibiting ChE makes it a significant tool for studying acetylcholine metabolism and related biological processes.

Cat. No.

A78816

CAS No.

3036136-22-5

AChE/BChE-IN-19

AChE/BChE-IN-19 is a nicotinic hydrazide derivative that acts as an inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 values of 21.45 nM and 18.42 nM, respectively. This compound is particularly relevant for studies investigating cholinergic dysfunction in neurodegenerative diseases, such as Alzheimer's disease. Its potent inhibitory activity makes it a valuable tool for exploring therapeutic strategies targeting cholinergic pathways.

Cat. No.

A78817

CAS No.

1346453-53-9

Methyl ganoderate A acetonide

Methyl ganoderate A acetonide is a lanostane triterpene that functions as a potent acetylcholinesterase (AChE) inhibitor, exhibiting an IC50 value of 18.35 μM. This natural compound, extracted from the fruiting bodies of Ganoderma lucidum, is utilized in research efforts focused on Alzheimer's disease (AD). Its inhibition of AChE makes it a valuable tool for investigating therapeutic strategies for cognitive decline associated with neurodegenerative disorders.

Cat. No.

A78818

CAS No.

1354-66-1

Floramultine

Synonyms: (S)-Floramultine; (S)-Bechuanine; Merenderine

Floramultine ((S)-Floramultine) is a reversible inhibitor of cholinesterase (ChE), demonstrating moderate potency and selectivity for various cholinesterase isoforms. This compound, derived from plant sources, exhibits significant cholinergic activity and can be utilized in research exploring the modulation of cholinergic neurotransmission. Applications include studies related to neurodegenerative disorders and the development of therapeutic agents targeting cholinergic dysfunction.

Cat. No.

A78819

CAS No.

1445475-53-5

Isograndifoliol

Isograndifoliol is a selective inhibitor of butyrylcholinesterase (BChE) with an IC50 of 0.9 μM, demonstrating moderate inhibition of acetylcholinesterase (AChE) with an IC50 of 342.9 μM. This compound exhibits vasorelaxant properties and potential anti-tumor activity. Isograndifoliol is relevant for research focused on neurodegenerative diseases, particularly in studies targeting dementia.

Cat. No.

A78820

CAS No.

20007-87-8

(-)-Cyclopenin

Synonyms: (-)-Cyclopenine

(-)-Cyclopenin is a selective acetylcholinesterase (AChE) inhibitor, exhibiting an IC50 value of 2.04 μM. This enantiomer of Cyclopenin demonstrates potent modulation of cholinesterase activity, making it a valuable tool for research into neurodegenerative diseases and cognitive function. Its capacity to regulate acetylcholine levels positions it as an important reagent for studies focused on synaptic transmission and cholinergic signaling pathways.

Cat. No.

A78821

CAS No.

32728-78-2

Heliosupine

Heliosupine is a pyrrolizidine alkaloid that acts as an acetylcholinesterase (AChE) inhibitor, exhibiting a reported IC50 of 0.57 mM. This compound demonstrates significant biological activity by deterring generalist herbivores, making it a valuable tool in ecological and pharmacological research. Its AChE inhibitory properties may also have implications for the study of neurodegenerative diseases and chemical ecology.

Cat. No.

A78822

CAS No.

3033056-55-9

AChE-IN-47

AChE-IN-47 is a potent acetylcholinesterase (AChE) inhibitor with an IC50 value of 0.24 μM. This compound effectively hinders the self-aggregation of amyloid β peptides, demonstrating neuroprotective properties. Additionally, AChE-IN-47 significantly reduces intracellular accumulation of reactive oxygen species, making it a valuable tool for research in neurodegenerative disease models and studies focused on oxidative stress.

Cat. No.

A78823

CAS No.

1189894-02-7

Azamethiphos-d6

Azamethiphos-d6 is a deuterated form of Azamethiphos, an organophosphate insecticide that primarily targets acetylcholinesterase (AChE). This compound is effectively used in research to study the inhibition of AChE activities and its implications in controlling sea lice populations. Azamethiphos-d6 serves as a valuable stable isotope for analytical studies and environmental monitoring of organophosphate residues.

Cat. No.

A78824

CAS No.

2490589-08-5

sEH/AChE-IN-1

sEH/AChE-IN-1 is a dual inhibitor targeting soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE). This compound exhibits significant biological activity in reducing neuroinflammation and memory impairment, making it a valuable tool for studying neurodegenerative diseases. Its application is particularly relevant in Alzheimer's disease research, where it may help elucidate disease mechanisms and potential therapeutic strategies.

Cat. No.

A78826

CAS No.

2770832-90-9

AChE-IN-10

AChE-IN-10 is a highly effective inhibitor of acetylcholinesterase (AChE), with an IC50 value of 2.4 nM. This compound demonstrates significant neuroprotective effects by enhancing neuronal morphology and increasing cell viability, while also reducing tau phosphorylation at the S396 residue. Additionally, AChE-IN-10 has been shown to decrease amyloid aggregation in conjunction with AChE activity, making it a valuable tool for research in neurodegenerative diseases and cognitive disorders.

Cat. No.

A78827

CAS No.

79183-25-8

BChE-IN-25

BChE-IN-25 is a selective inhibitor of butyrylcholinesterase (BChE), exhibiting an inhibitory concentration (IC50) of 3.77 μM. This compound demonstrates a 22-fold selectivity for BChE over acetylcholinesterase (AChE), making it a valuable tool for research applications in neurobiology and therapeutic development targeting cholinergic dysfunction. Researchers can utilize BChE-IN-25 to investigate the role of BChE in various physiological and pathological processes.

Cat. No.

A78829

CAS No.

3054159-55-3

BChE-IN-38

BChE-IN-38 is a potent butyrylcholinesterase (BChE) inhibitor demonstrating impressive Ki values of 62.05 nM for human carbonic anhydrase I (hCAI), 28.78 nM for human carbonic anhydrase II (hCAII), 14.09 nM for acetylcholinesterase (AChE), and 1.15 nM for BChE. In addition to its inhibitory effects, BChE-IN-38 exhibits notable cytotoxic activity. This compound is essential for research applications focusing on neurodegenerative disorders, drug development targeting cholinergic systems, and the study of enzyme inhibition mechanisms.

Cat. No.

A78830

CAS No.

1393102-59-4

HUHS2002

HUHS2002 is a free fatty acid derivative that primarily targets cholinesterase (ChE) to enhance α7 nicotinic acetylcholine receptor activity. This compound significantly increases whole-cell membrane currents of α7 ACh receptors expressed in Xenopus oocytes in a concentration-dependent manner, with effects reversibly blocked by the Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor KN-93. Furthermore, HUHS2002 activates CaMKII in cultured rodent hippocampal neurons, an effect also inhibited by KN-93. Additionally, HUHS2002 exhibits partial inhibition of protein phosphatase 1 (PP1) activity in a cell-free assay, suggesting its potential use in studying cholinergic signaling pathways and neuropharmacology.

Cat. No.

A78832

CAS No.

2749427-97-0

Acotiamide-d6

Synonyms: Z-338-d6 free base; YM443-d6 free base

Acotiamide-d6 is a deuterated form of Acotiamide, an orally active and first-in-class gastroprokinetic agent that acts as an acetylcholinesterase (AChE) inhibitor. This compound enhances gastrointestinal motility and is primarily used in research applications related to functional dyspepsia. Its unique isotopic labeling allows for advanced studies in pharmacokinetics and metabolic pathways, providing valuable insights into the drug's action and efficacy.

Cat. No.

A78834

CAS No.

100196-22-3

3-Acetylnerbowdine

3-Acetylnerbowdine is an alkaloid that can be isolated from the bulbs of N. bowdenii. This compound is primarily utilized in the study of acetylcholinesterase activity, providing insights into neurotransmission and potential therapeutic targets for neurological disorders. Its role in biological research may contribute to the understanding of cholinergic system modulation.

Cat. No.

A78836

CAS No.

128255-16-3

Axillaridine A

Axillaridine A is an acetylcholinesterase (AChE) inhibitor derived from Sarcococca hookeriana var. digyna. It effectively inhibits the catalytic activity of AChE, making it a valuable tool in the study of neurodegenerative diseases and cognitive function. This compound has potential applications in research exploring the modulation of cholinergic signaling and therapeutic strategies for conditions such as Alzheimer's disease.

Cat. No.

A78838

CAS No.

115-93-5

Cythioate

Cythioate is an organophosphorus compound that functions primarily as an insecticide and anthelmintic. It acts as an acetylcholinesterase inhibitor, disrupting neuromuscular transmission in ectoparasites, which leads to paralysis and mortality. Cythioate is utilized in agricultural and veterinary applications for the control of various pest and parasitic infestations.

Cat. No.

A78839

CAS No.

2528-36-1

Dibutyl phenyl phosphate

Dibutyl phenyl phosphate acts primarily as a flame retardant, with additional activity as a butyrylcholinesterase (BChE) inhibitor, exhibiting an IC50 value of 83.6 μM and a Ki of 94.5 μM. Its chemical structure contributes to its efficacy in enhancing fire safety in various materials. This compound is useful for research applications in the fields of material science and neurobiology, exploring both flame retardant properties and enzymatic inhibition.

Cat. No.

A78840

CAS No.

302-40-9

Benactyzine

Benactyzine is a competitive inhibitor of butyrylcholinesterase (BChE) with a Ki value of 0.01 mM. This anticholinergic agent exhibits significant biological activity by blocking cholinergic transmission, making it relevant in studies related to neurological disorders and organophosphate poisoning. Benactyzine is a valuable tool for research applications focused on cholinergic receptor pathways and the effects of anticholinergic compounds.

Cat. No.

A78841

CAS No.

386211-69-4

Quinolactacin A2

Quinolactacin A2 is an acetylcholinesterase inhibitor that effectively reduces the breakdown of acetylcholine, thereby enhancing cholinergic neurotransmission. Additionally, this compound has been shown to inhibit tumor necrosis factor (TNF) production, which may have implications in inflammatory and neurodegenerative research. Quinolactacin A2 is valuable in studies investigating cholinergic signalling and its role in various pathophysiological conditions.

Cat. No.

A78842

CAS No.

56-97-3

Trimedoxime

Synonyms: TMB-4

Trimedoxime, also known as TMB-4, is a potent reactivator of acetylcholinesterase (AChE). This compound is particularly effective in restoring AChE activity following inhibition by organophosphates. Additionally, Trimedoxime has been demonstrated to induce oxidative stress, with an IC50 value of 22 mM, making it a valuable tool in biochemical research focused on the mechanisms of neurotoxicity and therapeutic interventions for nerve agent exposure.

Cat. No.

A78843

CAS No.

182068-83-3

Arisugacin B

Arisugacin B is a selective acetylcholinesterase (AChE) inhibitor with potent oral bioactivity. Its mechanism of action involves the inhibition of AChE, which plays a crucial role in neurotransmission by regulating acetylcholine levels. This compound is useful in research applications focused on neurodegeneration and related disorders, offering insights into potential therapeutic strategies for conditions such as Alzheimer's disease.