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Biological Activity
PF-04691502 is a PI3K/mTOR kinase inhibitor, is also an agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway.
Targets
| Target | Value |
|---|---|
| PI3Kδ | ki: 1.6nM |
| PI3Kα | ki: 1.8nM |
| PI3Kγ | ki: 1.9nM |
| PI3Kβ | ki: 2.1nM |
| P-Akt(S473) | IC50: 3.8nM |
| P-Akt(T308) | IC50: 7.5nM |
| mTOR | ki: 16nM |
| In vitro | DMSO | 13 mg/mL (30.55 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.5 mL | 117.51 mL | 235.02 mL |
| 0.5 mM | 4.7 mL | 23.5 mL | 47 mL |
| 1 mM | 2.35 mL | 11.75 mL | 23.5 mL |
| 5 mM | 0.47 mL | 2.35 mL | 4.7 mL |
*The above data is based on the productmolecular weight 425.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11024 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1013101-36-4 |
| Formula | C22H27N5O4 |
| M. Wt | 425.5 |
| Purity | >98% |
| Synonyms | PF04691502 |
| SMILES | CC1=C2C=C(C(=O)N(C2=NC(=N1)N)C3CCC(CC3)OCCO)C4=CN=C(C=C4)OC |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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