MMP

Cat. No.

A46667

CAS No.

3219-99-6

6-epi Doxycycline

6-Epi Doxycycline is the C-6 epimer of Doxycycline, resulting from epimerization under specific conditions such as elevated temperature, pH variation, or high humidity. This compound serves as a critical reference standard for the detection and quantification of impurities in pharmaceutical formulations. Its utility extends to analytical studies assessing the stability and degradation pathways of doxycycline and similar antibiotics.

Cat. No.

A53471

CAS No.

689284-12-6

(R)-TAPI-2

Synonyms: (R)-TNF Protease Inhibitor 2

(R)-TAPI-2 is a potent inhibitor targeting matrix metalloproteinases (MMPs), tumor necrosis factor alpha-converting enzyme (TACE), and a disintegrin and metalloproteinase (ADAM), exhibiting an IC50 value of 20 μM for MMP activity. This compound is utilized in research focused on inflammation, cancer progression, and cell signaling due to its ability to modulate proteolytic processes. Additionally, (R)-TAPI-2 has demonstrated efficacy in preventing viral entry, specifically in the context of SARS-CoV infections, making it valuable for virology studies.

Cat. No.

A57306

CAS No.

1258003-93-8

(R)-MMP408

(R)-MMP408 is a potent inhibitor of matrix metalloproteinase-12 (MMP-12), exhibiting an IC50 of 2.0 nM for human MMP-12. This compound effectively modulates the epithelial-mesenchymal transition (EMT) by upregulating E-cadherin in nasal epithelial cells while simultaneously inhibiting mesenchymal markers such as vimentin, α-smooth muscle actin, and fibronectin, thus reversing the EMT phenotype. (R)-MMP408 is instrumental in research related to airway remodeling diseases, including chronic rhinosinusitis with nasal polyps, chronic obstructive pulmonary disease (COPD), and asthma.

Cat. No.

A57338

CAS No.

259188-38-0

Rebimastat

Synonyms: BMS 275291

Rebimastat is an orally active, broad-spectrum inhibitor of matrix metalloproteinases (MMPs) and a non-peptide collagen mimetic. It exhibits selective inhibition, allowing for modulation of specific MMP activities without affecting all collagenase functions. Rebimastat is utilized in research related to colorectal cancer, providing insights into the role of MMPs in tumor progression and metastasis.

Cat. No.

A63845

CAS No.

57680-56-5

Sucrose octasulfate

Sucrose octasulfate is a matrix metalloproteinase (MMP) inhibitor that modulates cellular activities by regulating the extracellular matrix. It promotes the release of somatostatin-like immunoreactivity from gastric D cells, facilitating ulcer healing through increased endogenous somatostatin levels. This compound has demonstrated efficacy in improving wound closure in diabetic foot ulcers and venous leg ulcers, making it pertinent for research in chronic wound healing and gastrointestinal disorders. Additionally, sucrose octasulfate serves as a valuable pharmaceutical excipient in various therapeutic applications.

Cat. No.

A63873

CAS No.

74135-10-7

Sucrose octasulfate sodium

Sucrose octasulfate sodium is a potent matrix metalloproteinase (MMP) inhibitor that enhances the release of somatostatin-like immunoreactivity (SLI) from gastric D cells. This compound promotes ulcer healing by increasing endogenous gastric somatostatin levels. Sucrose octasulfate sodium is utilized in research related to chronic wound healing and has shown significant efficacy in improving wound closure in diabetic foot ulcers and venous leg ulcers. Additionally, it serves as a useful pharmaceutical excipient in various applications.

Cat. No.

A67124

CAS No.

1176758-04-5

Otaplimastat

Synonyms: SP-8203

Otaplimastat is a matrix metalloproteinase (MMP) inhibitor that effectively suppresses N-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity through competitive inhibition. In addition to its role as an MMP inhibitor, Otaplimastat displays antioxidant properties. This compound is valuable for research focused on brain ischemic injury and related neuroprotective mechanisms.

Cat. No.

A67291

CAS No.

1176758-02-3

Otaplimastat hydrochloride

Synonyms: SP-8203 hydrochloride

Otaplimastat hydrochloride is a selective inhibitor of matrix metalloproteinases (MMPs), known to mitigate N-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity through competitive binding. This compound also demonstrates antioxidant properties, making it relevant for studies involving oxidative stress. Otaplimastat hydrochloride is primarily utilized in research related to brain ischemic injury and neuronal protection.

Cat. No.

A71320

CAS No.

158841-76-0

MMP3 inhibitor 3

MMP3 inhibitor 3 is a selective inhibitor targeting matrix metalloproteinase 3 (MMP3). This compound demonstrates significant biological activity in modulating extracellular matrix remodeling and is particularly relevant in the study of breast cancer progression and metastasis. Researchers can utilize MMP3 inhibitor 3 to explore its effects on tumor biology and investigate the therapeutic potential of MMP3 inhibition in cancer treatment.

Cat. No.

A72090

CAS No.

244082-19-7

CTTHWGFTLC, CYCLIC

CTTHWGFTLC, CYCLIC is a cyclic peptide that selectively inhibits matrix metalloproteinases MMP-2 and MMP-9. This compound demonstrates an IC50 value of approximately 8 μM for MMP-9, making it a valuable tool for studying the roles of these enzymes in various biological processes. It is particularly applicable in research focused on cancer metastasis, tissue remodeling, and inflammatory responses.

Cat. No.

A73060

CAS No.

130370-59-1

GI-129471

GI-129471 is a potent matrix metalloproteinase (MMP) inhibitor. It effectively inhibits cancer cell invasion and completely blocks the enhanced production of immunoglobulin E (IgE) and immunoglobulin G1 (IgG1) in mouse B cells induced by rat mast cell protease-I (RMCP-I). This compound is valuable for research focused on cancer biology and mast cell chymase-regulated immunological processes.

Cat. No.

A73362

CAS No.

1664361-37-8

CM-352

CM-352 is a potent inhibitor of matrix metalloproteinases (MMPs), specifically targeting MMP-3 with an IC50 of 15 nM and MMP-10 with an IC50 of 12 nM. This compound exhibits significant antifibrinolytic activity, with an EC50 of 0.7 nM, effectively prolonging blood coagulation time. CM-352 is valuable for research applications focused on anti-bleeding strategies and the modulation of extracellular matrix dynamics.

Cat. No.

A73404

CAS No.

1807453-72-0

ND-378

ND-378 is a potent and selective inhibitor of matrix metalloproteinase-2 (MMP-2), exhibiting a Ki value of 230 nM. It is primarily utilized in research investigating the mechanisms and therapies associated with spinal cord injury (SCI). By inhibiting MMP-2, ND-378 can help elucidate the role of extracellular matrix remodeling in neurological conditions and potential therapeutic strategies.

Cat. No.

A73546

CAS No.

748120-89-0

SD-7300

Synonyms: SC-81490; PF-02881307

SD-7300 is a potent and selective inhibitor of matrix metalloproteinases (MMP-2, MMP-9, and MMP-13) with Ki values of 0.03, 0.01, and 0.03 nM, respectively. This compound effectively reduces extracellular matrix degradation by tumor cells, thus inhibiting their invasion and metastasis. Additionally, SD-7300 serves as a dose-dependent inhibitor of corneal angiogenesis in mice and mitigates interleukin-1-induced cartilage degradation in bovine models. It is valuable for research applications focused on breast cancer and related studies.

Cat. No.

A73607

CAS No.

220614-50-6

ABT-770

ABT-770 is a selective and orally active inhibitor of matrix metalloproteinase 2 (MMP-2), exhibiting over 1000-fold selectivity with an IC50 of 4 nM compared to MMP-1 (IC50 = 4600 nM). This compound is valuable for research into tumor biology, particularly in studies focused on tumor growth, invasion, and metastasis, providing insights into the role of MMP-2 in cancer progression.

Cat. No.

A73816

CAS No.

108887-68-9

Isozedoarondiol

Isozedoarondiol is a selective inhibitor of matrix metalloproteinase-1 (MMP-1). Found in the rhizomes of Curcuma xanthorrhiza Roxb, this compound effectively reduces MMP-1 expression in UVB-treated human keratinocytes. Isozedoarondiol is valuable for research focused on skin biology, inflammation, and related therapeutic interventions.

Cat. No.

A73869

CAS No.

1025717-75-2

MMP145

MMP145 is a selective and potent inhibitor of matrix metalloproteinase-12 (MMP-12), with oral bioavailability. This compound demonstrates significant anti-inflammatory activity, making it valuable for research in asthma and other inflammation-related conditions. MMP145 is a useful tool for studying the role of MMP-12 in various biological processes and therapeutic interventions.

Cat. No.

A73979

CAS No.

20734-66-1

3-Aminobenzene-1,2-diol

3-Aminobenzene-1,2-diol is a potent inhibitor of matrix metalloproteinases (MMPs), specifically targeting MMP-2, MMP-8, MMP-9, and MMP-14 with IC50 values of 20, 26, 16, and 16.3 μM, respectively. Its selective inhibition of these enzymes highlights its potential in research applications related to tissue remodeling, cancer metastasis, and inflammation. This compound serves as a valuable tool for studying the role of MMPs in various biological processes.

Cat. No.

A74170

CAS No.

140638-26-2

Matlystatin E

Matlystatin E is a selective inhibitor of matrix metalloproteinases (MMPs), which play a crucial role in extracellular matrix remodeling and tissue repair. This compound exhibits significant activity in inhibiting MMP-mediated processes, making it valuable in therapeutic research related to cancer metastasis, fibrosis, and inflammatory diseases. Its use in studies targeting MMP pathways can enhance the understanding of disease progression and treatment efficacy.

Cat. No.

A74185

CAS No.

140667-42-1

Matlystatin F

Matlystatin F is a potent inhibitor of metalloproteinases (MMPs), enzymes that play a critical role in extracellular matrix remodeling. By selectively inhibiting MMP activity, Matlystatin F can contribute to studies focused on cancer metastasis, tissue repair, and inflammatory processes. This compound is essential for researchers investigating the therapeutic potential of modulating MMP activity in various pathological conditions.

Cat. No.

A74283

CAS No.

171347-75-4

GM1489

GM1489 is an MMP inhibitor that effectively reduces degradation at the resin-dentin interface by targeting matrix metalloproteinases (MMPs). This compound enhances bonding stability, making it a valuable tool for investigating methods to improve bonding in both superficial and deep dentin. Its applications extend to studies focused on dental materials and their interaction with dentin substrates.

Cat. No.

A74305

CAS No.

140638-25-1

Matlystatin D

Matlystatin D is a specific inhibitor of matrix metalloproteinases (MMPs), which play a critical role in extracellular matrix remodeling and tissue repair. It demonstrates potent biological activity in inhibiting MMPs, making it a valuable tool in studies related to cancer metastasis, inflammatory diseases, and tissue fibrosis. This compound is useful for research applications focusing on the modulation of extracellular matrix dynamics and the investigation of MMP-related pathways in various biological contexts.

Cat. No.

A74347

CAS No.

206551-25-9

WAY-151693

WAY-151693 is a potent inhibitor of matrix metalloproteinase 13 (MMP13), functioning through a sulfonamide derivative of hydroxamic acid. This compound exhibits significant biological activity, making it a valuable tool for studying the modulation of extracellular matrix remodeling. Its research applications include investigations into tissue repair, cancer progression, and inflammatory diseases, where MMP13 plays a crucial role.

Cat. No.

A74357

CAS No.

769970-91-4

LY52

LY52 is a potent inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9, effectively reducing their proteolytic activity. In vitro studies demonstrate that LY52 markedly decreases the expression of MMP-2 and MMP-9 in SKOV3 ovarian cancer cells, leading to inhibited cell invasion. Additionally, in vivo research indicates that LY52 can suppress pulmonary metastasis of Lewis lung carcinoma cells in murine models. This compound serves as a valuable tool in cancer research, particularly in studies focused on the roles of MMPs in tumor progression and metastasis.

Cat. No.

A74500

CAS No.

158018-53-2

4-Epianhydrochlortetracycline hydrochloride

4-Epianhydrochlortetracycline hydrochloride acts as a potent inhibitor of matrix metalloproteinases (MMPs), specifically targeting gelatinase B (Gelatinase B, EC 3.4.24.35). Demonstrating complete inhibition at a concentration of 500 μg/mL, and notable inhibition rates of 70% at 125 μg/mL and 40% at 31 μg/mL, this compound offers significant potential for research into chronic inflammatory diseases. Its efficacy in modulating MMP activity makes it a valuable tool for investigating the underlying mechanisms of tissue remodeling and inflammation.