MMP

Cat. No.

A76833

CAS No.

102067-92-5

Epitheaflagallin 3-O-gallate

Epitheaflagallin 3-O-gallate is a selective matrix metalloproteinase (MMP) inhibitor. This minor polyphenol, found in black tea, exhibits significant anti-inflammatory and antioxidative properties. It effectively inhibits pancreatic lipase and Streptococcus sorbinus glycosyltransferase, while also reducing the activity and synthesis of MMP-1 and MMP-3 in human gingival fibroblasts. These biological activities make it a valuable tool for research in inflammation and tissue remodeling studies.

Cat. No.

A76836

CAS No.

2865102-08-3

TP0628103

TP0628103 is a potent selective inhibitor of matrix metalloproteinase-7 (MMP-7), demonstrating an IC50 value of 0.17 nM. MMP-7 is implicated in various pathological processes, including cancer progression and fibrosis. This compound is valuable for research applications focusing on the modulation of MMP-7 activity in cancer and fibrotic diseases.

Cat. No.

A76837

CAS No.

2490543-89-8

MMP-9-IN-8

MMP-9-IN-8 is a selective matrix metalloproteinase-9 (MMP-9) inhibitor that exhibits inhibitory activities of 42.16% and 58.28% at concentrations of 10 μM and 50 μM, respectively. This compound demonstrates notable anti-cancer properties, effectively inducing apoptosis in MCF-7 breast cancer cells, with an IC50 value of 23.42 μM. MMP-9-IN-8 is suitable for research applications involving cancer biology and therapeutic development targeting tumor progression and metastasis.

Cat. No.

A76839

CAS No.

2252493-33-5

(R)-ND-336

(R)-ND-336 is a selective inhibitor of matrix metalloproteinase-9 (MMP-9), exhibiting a Ki value of 19 nM. It also demonstrates inhibitory activity against MMP-2 (Ki=127 nM) and MMP-14 (Ki=119 nM). This compound is useful for investigating therapeutic approaches in conditions such as diabetic foot ulcers (DFUs) and plays a critical role in studies related to tissue remodeling and wound healing.

Cat. No.

A76840

CAS No.

92535-43-8

MMP2-IN-4

MMP2-IN-4 is a selective inhibitor targeting matrix metalloproteinase 2 (MMP2). It demonstrates potent inhibition of MMP2, MMP9, and MMP12, exhibiting IC50 values of 266.74 nM, 402.75 nM, and 1237.39 nM, respectively. This compound is valuable for research applications focused on understanding the role of MMPs in various pathological conditions, including cancer metastasis and tissue remodeling.

Cat. No.

A76841

CAS No.

161314-70-1

CGS 27023A free base

CGS 27023A free base is a potent, non-peptidic inhibitor of matrix metalloproteinases (MMPs), demonstrating Ki values of 43 nM for MMP-3, 33 nM for MMP-1, 20 nM for MMP-2, and 8 nM for MMP-9. This compound effectively inhibits cartilage degradation in a stromelysin-induced rabbit model, making it a valuable tool for studying the pathogenesis of arthritis and potential therapeutic interventions. Its selective inhibition of MMPs underscores its relevance in research focused on inflammatory and degenerative joint diseases.

Cat. No.

A76843

CAS No.

869298-22-6

T 26c sodium

T26c sodium is a highly potent and selective inhibitor of MMP-13, exhibiting an IC50 value of 6.9 pM. This compound effectively prevents the degradation of bovine nasal septal cartilage explants, making it a valuable tool for research into cartilage metabolism and tissue preservation. T26c sodium is particularly useful in studies related to arthritis and other degenerative joint diseases where MMP-13 plays a critical role in extracellular matrix remodeling.

Cat. No.

A76844

CAS No.

230954-09-3

CP-544439

CP-544439 is a potent inhibitor of matrix metalloproteinase-13 (MMP-13) with an IC50 of 0.75 nM. This compound effectively modulates extracellular matrix remodeling and has potential applications in the study of various diseases characterized by tissue degradation and inflammation. Its oral bioactivity makes CP-544439 a valuable tool for researchers investigating the role of MMP-13 in pathological conditions.

Cat. No.

A76845

CAS No.

766536-21-4

PF-00356231

PF-00356231 is a selective inhibitor of matrix metalloproteinase MMP-12, exhibiting an IC50 value of 1.4 μM. This non-peptidic compound forms a stable complex with MMP-12 and further demonstrates activity against MMP-13, MMP-8, MMP-9, and MMP-3 with IC50 values of 0.00065, 1.7, 0.98, and 0.39 μM, respectively. PF-00356231 is valuable for research into inflammation, tissue remodeling, and various diseases involving aberrant matrix metalloproteinase activity.

Cat. No.

A76846

CAS No.

226072-63-5

Solimastat

Synonyms: BB-3644

Solimastat is a potent metalloproteinase (MMP) inhibitor that effectively blocks both constitutive and antibody-stimulated shedding of CD30 from cell surfaces, exhibiting an IC50 of 180 nM. This compound enhances the persistence of the anti-CD30 antibody Ki-3 on targeted cells and promotes its internalization. Additionally, Solimastat increases the cytotoxicity of Ki-3.dgA towards CD30+ L540 cells. It serves as a valuable reagent for research focused on CD30+ malignancies.

Cat. No.

A76849

CAS No.

169799-04-6

CGS 27023A

CGS 27023A is a non-peptidic, orally active inhibitor of matrix metalloproteinases (MMPs), exhibiting Ki values of 43 nM for MMP-3, 33 nM for MMP-1, 20 nM for MMP-2, and 8 nM for MMP-9. This compound effectively prevents cartilage degradation in a stromelysin-induced rabbit cartilage model. CGS 27023A is suitable for studying diseases such as arthritis and exploring the role of MMPs in various pathological conditions.

Cat. No.

A76852

CAS No.

1816257-74-5

BAY-7598

BAY-7598 is a selective inhibitor of matrix metalloproteinase 12 (MMP12), demonstrating potent activity with IC50 values of 0.085 nM for human MMP12, 0.67 nM for murine MMP12, and 1.1 nM for rat MMP12. This orally bioavailable compound is valuable for research applications involving chronic inflammatory diseases, where MMP12 plays a critical role in tissue remodeling and inflammation. Its specificity for MMP12 allows for targeted studies in the mechanistic understanding of these conditions.

Cat. No.

A76853

CAS No.

2787582-17-4

TP0556351

TP0556351 is a highly selective inhibitor of matrix metalloproteinase-2 (MMP2), exhibiting an IC50 value of 0.2 nM. This compound effectively decreases collagen accumulation in a murine model of Bleomycin-induced pulmonary fibrosis, making it a valuable tool for investigating idiopathic pulmonary fibrosis (IPF) and related fibrotic disorders. Researchers can utilize TP0556351 to explore the mechanisms of collagen turnover and therapeutic strategies targeting MMP2 in fibrotic diseases.

Cat. No.

A76854

CAS No.

261956-22-3

RO-28-2653

RO-28-2653 is an orally active inhibitor of matrix metalloproteinases (MMPs), specifically targeting MMP2, MMP9, and membrane-type 1-MMP. This compound exhibits selective inhibitory effects, potentially reducing side effects associated with broad-spectrum MMP inhibitors, such as musculoskeletal pain. In preclinical studies, RO-28-2653 has demonstrated significant tumor growth inhibition in rat models of prostate cancer, making it a valuable tool for research on hormone-sensitive tumors and related therapeutic applications.

Cat. No.

A76856

CAS No.

166245-54-1

OPB-3206

OPB-3206 is a selective matrix metalloproteinase (MMP) inhibitor that targets MMP-2, MMP-9, interstitial collagenase, and stromelysin with IC50 values of 7×10^-7 M, 5×10^-6 M, 5×10^-7 M, and 2×10^-6 M, respectively. By reversibly binding to the zinc-binding region of MMPs, OPB-3206 effectively prevents the activation of MMP-9, thereby reducing extracellular matrix degradation and inhibiting tumor lung metastasis. This compound shows promise for research focused on the metastatic behavior of osteosarcoma.

Cat. No.

A76857

CAS No.

333746-76-2

MMP-9-IN-7

MMP-9-IN-7 is a selective inhibitor of matrix metalloproteinase-9 (MMP-9) with an IC50 of 0.52 μM, as determined in the proMMP9/MMP3 P126 activation assay. This compound is sourced from patent WO2012162468 (example 59) and is suitable for investigating MMP-9 and MMP-13 mediated syndromes. Its potency and specificity make it a valuable tool in the study of MMP-associated pathologies and therapeutic research.

Cat. No.

A76858

CAS No.

106314-87-8

U27391

U27391 is a metalloproteinase inhibitor that specifically targets matrix metalloproteinases (MMPs). It is effective in inhibiting rhIL-1β induced proteoglycan loss, demonstrating its potential for research in cartilage degradation and inflammatory processes. U27391 is valuable for studies investigating osteoarthritis and other conditions associated with metalloproteinase activity.

Cat. No.

A76862

CAS No.

127033-74-3

(E)-N-(3-Methoxyphenyl)cinnamamide

(E)-N-(3-Methoxyphenyl)cinnamamide primarily targets the metalloproteinases MMP-2 and MMP-9, acting as a weakly selective inhibitor. It demonstrates inhibitory activity with IC50 values of 1674.81 nM for hMMP-2 and 1658.63 nM for hMMP-9, showing limited selectivity for MMP-1. This compound is relevant for cancer research, particularly in studies investigating tumor invasion and metastasis mediated by matrix metalloproteinases.

Cat. No.

A76863

CAS No.

179545-76-7

(Rac)-Tanomastat

Synonyms: (Rac)-BAY 12-9566

(Rac)-Tanomastat is a racemic mixture of the non-peptidic biphenyl compound Tanomastat, which functions as a selective inhibitor of matrix metalloproteinases (MMPs) through a zinc-binding carboxyl group. It exhibits Ki values of 11, 143, 301, and 1470 nM for MMP-2, MMP-3, MMP-9, and MMP-13, respectively. This compound demonstrates significant anti-invasive and antimetastatic properties in various experimental tumor models, making it a valuable tool for cancer research and therapeutic investigations focused on metastasis.

Cat. No.

A76864

CAS No.

87725-60-8

Smyrindiol

Synonyms: (2'S, 3'R)-3'-Hydroxymarmesin

Smyrindiol is an MMP-2 inhibitor derived from Dorstenia turbinate. This compound has demonstrated anti-inflammatory and antimicrobial properties through its ability to inhibit the secretion of tumor-associated proteases. Smyrindiol is applicable in research focused on brain tumors, including glioblastoma, providing insights into tumor biology and potential therapeutic strategies.

Cat. No.

A76866

CAS No.

3085676-77-0

MMP-9-IN-13

MMP-9-IN-13 is a potent and selective inhibitor of human matrix metalloproteinase 9 (MMP-9), exhibiting an IC50 value of 0.02 nM. This compound is valuable for studying the role of MMP-9 in ocular surface research, particularly in understanding its impact on tissue remodeling and inflammation. MMP-9-IN-13 can aid in elucidating the molecular mechanisms underlying various ocular conditions and potential therapeutic interventions.

Cat. No.

A76867

CAS No.

137530-61-1

BE-16627B

BE-16627B is a metalloproteinase inhibitor that exhibits potent activity in enzyme assays. Isolated from microbial cultures, this compound has demonstrated the ability to reduce the number and size of HT1080 cell nodules on the lung surface in murine models, as well as inhibit HT1080 cell growth in vivo. BE-16627B serves as a valuable tool for research in anti-cancer studies, particularly in understanding the role of metalloproteinases in tumor progression.

Cat. No.

A76868

CAS No.

2415311-84-9

MMP-2/9-IN-1

MMP-2/9-IN-1 is a potent dual inhibitor of matrix metalloproteinases MMP-2 and MMP-9, exhibiting IC50 values of 56 nM and 38 nM, respectively. This compound demonstrates significant anti-tumor activity by inhibiting tumor growth, promoting cancer cell apoptosis, and suppressing cell migration and cell cycle progression, which ultimately results in DNA fragmentation. MMP-2/9-IN-1 is valuable for research applications focused on cancer therapeutics and the underlying mechanisms of metastasis.

Cat. No.

A76870

CAS No.

120928-08-7

Pro-Leu-Gly-NHOH hydrochloride

Pro-Leu-Gly-NHOH hydrochloride is a selective inhibitor of matrix metalloproteinase-8 (MMP-8). It modulates extracellular matrix remodeling and has key implications in inflammatory processes and tissue repair. This reagent is useful in research applications involving the study of MMP-mediated pathways and their role in various diseases.

Cat. No.

A76875

CAS No.

906366-79-8

Inotilone

Inotilone is a selective inhibitor of matrix metalloproteinases MMP-2 and MMP-9, which are key enzymes involved in the metastatic progression of lung cancer. This compound enhances the activity of antioxidant enzymes, contributing to its anti-metastatic properties. Additionally, Inotilone inhibits IκBα phosphorylation and the nuclear translocation of NFκB p65, influencing various signaling pathways including FAK, PI3K/AKT, MAPKs, and NFκB. Inotilone is suitable for research applications focused on cancer metastasis and treatment strategies.