MMP

Cat. No.

A76777

CAS No.

66-71-7

o-Phenanthroline

Synonyms: 1,10-Phenanthroline

o-Phenanthroline is a potent matrix metalloproteinase (MMP) inhibitor that also acts as a metal chelator. It effectively prevents chromosomal aberrations in cells treated with streptozotocin. Within biological systems, o-Phenanthroline forms a stable red chelate with Fe2+, exhibiting peak absorbance at 510 nm. This compound is widely utilized in research applications focusing on metalloprotein interactions and cellular responses to stress.

Cat. No.

A76781

CAS No.

236403-25-1

MMP-8 inhibitor-1

Synonyms: MMP8-I

MMP-8 inhibitor-1 is a potent inhibitor of matrix metalloproteinase-8 (MMP-8), designed to modulate extracellular matrix remodeling. This hydroxamic acid derivative demonstrates significant selectivity for MMP-8, making it a valuable tool for studying the role of this protease in various biological processes and disease models. Its primary applications include research on inflammation, cancer metastasis, and tissue remodeling, providing insights into therapeutic strategies targeting MMP-8 activity.

Cat. No.

A76782

CAS No.

877176-23-3

Aderamastat

Synonyms: FP-025

Aderamastat is a selective inhibitor of MMP-12, providing a targeted approach to modulating extracellular matrix remodeling. This compound demonstrates protective effects against house dust mite-sensitized allergic asthma and is valuable in the study of respiratory diseases, such as chronic inflammatory airway conditions and pulmonary fibrosis. Its selectivity and oral bioavailability make it an important tool for exploring therapeutic interventions in related pathologies.

Cat. No.

A76783

CAS No.

2865097-05-6

MMP-7-IN-1

MMP-7-IN-1 is a selective inhibitor of matrix metalloproteinase-7 (MMP-7) with an IC50 of 10 nM. This compound plays a significant role in inhibiting MMP-7 enzymatic activity, which is implicated in various pathological processes, including tumor progression and fibrosis. MMP-7-IN-1 is valuable for research applications focused on understanding and targeting MMP-7-related diseases.

Cat. No.

A76785

CAS No.

10335-69-0

MMP-2 Inhibitor I

MMP-2 Inhibitor I (OA-Hy) is a potent inhibitor of matrix metalloproteinase-2 (MMP-2) with a Ki value of 1.7 μM. This compound is primarily utilized in research to study the role of MMP-2 in various biological processes, including tissue remodeling and cancer metastasis. Its inhibitory activity makes it a valuable tool for investigating potential therapeutic strategies in diseases where MMP-2 is implicated.

Cat. No.

A76788

CAS No.

1807453-83-3

ND-336

ND-336 is a selective inhibitor of matrix metalloproteinases (MMP)-2, MMP-9, and MMP-14, exhibiting inhibition constants (Kis) of 85, 150, and 120 nM, respectively. This compound has demonstrated significant biological activity in promoting diabetic wound healing in murine models by reducing inflammation and enhancing both angiogenesis and re-epithelialization. ND-336 serves as a valuable tool for research in wound healing, tissue repair, and inflammatory processes.

Cat. No.

A76790

CAS No.

1222173-37-6

BI-4394

Synonyms: MMP13-IN-3

BI-4394 is a potent and selective inhibitor of matrix metalloproteinase-13 (MMP-13), with an IC50 of 1 nM. This orally bioavailable compound exhibits greater than 1000-fold selectivity over other MMPs, making it a valuable tool for investigating the role of MMP-13 in osteoarthritis and related conditions. Its activity offers potential applications in the study of cartilage degradation and therapeutic approaches targeting this specific pathway.

Cat. No.

A76791

CAS No.

935759-55-0

MMP13-IN-2

MMP13-IN-2 is a highly potent and selective inhibitor of matrix metalloproteinase-13 (MMP-13), with an IC50 value of 0.036 nM. Demonstrating over 1,500-fold selectivity for MMP-13 compared to other MMPs such as MMP-1, 3, 7, 8, 9, 14, and TACE, this compound effectively blocks collagen release from cartilage in vitro. MMP13-IN-2 is valuable for research focusing on collagenase-related diseases and investigating the role of MMP-13 in various pathological conditions.

Cat. No.

A76792

CAS No.

203915-59-7

MMP Inhibitor II

MMP Inhibitor II is a potent, reversible pan-MMP inhibitor targeting matrix metalloproteinases (MMPs) with impressive IC50 values of 24 nM, 18.4 nM, 30 nM, and 2.7 nM for MMP-1, MMP-3, MMP-7, and MMP-9, respectively. This compound effectively modulates MMP activity, making it a valuable tool for research in cancer metastasis, tissue remodeling, and inflammatory processes. Its specificity and potency enable detailed studies of MMP-mediated pathways and therapeutic interventions.

Cat. No.

A76793

CAS No.

284667-65-8

RXP03

RXP03 is a potent inhibitor of matrix metalloproteinases (MMPs), exhibiting Ki values of 20 nM for MMP-2, 2.5 nM for MMP-8, 10 nM for MMP-9, 5 nM for MMP-11, and 105 nM for MMP-14. This compound effectively modulates extracellular matrix remodeling and is valuable in studying various pathological conditions such as cancer metastasis and tissue inflammation. RXP03 serves as a crucial tool for researchers investigating MMP-related biological processes and therapeutic interventions.

Cat. No.

A76795

CAS No.

168158-16-5

KB-R7785

KB-R7785 is a selective inhibitor of matrix metalloproteinases (MMPs), known for its ability to enhance insulin sensitivity through the inhibition of TNF-α production. This compound is valuable for research in diabetes and metabolic disorders. Additionally, KB-R7785 demonstrates protective effects against focal cerebral ischemia, making it relevant for studies focused on neuroprotection and ischemic injury.

Cat. No.

A76796

CAS No.

179545-77-8

Tanomastat

Synonyms: BAY 12-9566

Tanomastat is a non-peptidic biphenyl inhibitor of matrix metalloproteinases (MMPs), featuring a Zn-binding carboxyl group that enhances its efficacy. It demonstrates potent inhibition with Ki values of 11 nM for MMP-2, 143 nM for MMP-3, 301 nM for MMP-9, and 1470 nM for MMP-13. Tanomastat exhibits significant anti-invasive and antimetastatic properties in various experimental tumor models, making it a valuable tool for cancer research and therapeutic investigations targeting MMP activity.

Cat. No.

A76797

CAS No.

2865106-78-9

TP0628103 TFA

TP0628103 TFA is a selective inhibitor of matrix metalloproteinase 7 (MMP-7), exhibiting an IC50 value of 0.17 nM. This compound is significant in research related to cancer progression and fibrosis, as it modulates the activity of MMP-7, a key molecule involved in extracellular matrix remodeling. TP0628103 TFA is valuable for studying the therapeutic potential of MMP-7 inhibition in various disease models.

Cat. No.

A76799

CAS No.

204140-01-2

MMP-9/MMP-13 Inhibitor I

MMP-9/MMP-13 Inhibitor I is a highly selective inhibitor targeting matrix metalloproteinases 9 and 13, exhibiting IC50 values of 0.9 nM for both enzymes. This inhibitor demonstrates over 20-fold selectivity for MMP-9 and MMP-13 compared to other matrix metalloproteinases. It is valuable for research into extracellular matrix remodeling, tissue repair, and various pathological conditions including cancer and inflammatory diseases.

Cat. No.

A76800

CAS No.

891198-31-5

RXP470.1

Synonyms: RXP-470

RXP470.1 is a potent and selective inhibitor of matrix metalloproteinase-12 (MMP-12), exhibiting a Ki of 0.2 nM in human MMP-12 assays. This compound demonstrates significantly lower activity against other MMPs, enhancing its specificity. RXP470.1 has been shown to effectively reduce atherosclerotic plaque cross-sectional area in murine models, resulting in improved plaque complexity characterized by an increased smooth muscle cell to macrophage ratio, decreased macrophage apoptosis, enhanced cap thickness, smaller necrotic cores, and reduced calcification incidence. This makes RXP470.1 a valuable tool for studying cardiovascular diseases and related inflammatory conditions.

Cat. No.

A76801

CAS No.

193807-58-8

MMP-2/MMP-9-IN-1

MMP-2/MMP-9-IN-1 is a selective inhibitor targeting MMP-2 and MMP-9, crucial enzymes involved in extracellular matrix degradation. With IC50 values of 0.24 μM for MMP-9 and 0.31 μM for MMP-2, this compound demonstrates potent activity in inhibiting tumor growth and metastasis in preclinical models. MMP-2/MMP-9-IN-1 is a valuable tool for cancer research, facilitating studies on the role of matrix metalloproteinases in tumor progression and invasion.

Cat. No.

A76802

CAS No.

1382722-47-5

MMPI-1154

MMPI-1154 is an imidazole-carboxylic acid (ICA) compound that serves as a potent inhibitor of matrix metalloproteinase-2 (MMP-2), exhibiting an IC50 value of 6.6 μM. This novel reagent also displays inhibitory effects on MMP-13, MMP-1, and MMP-9, with corresponding IC50 values of 1.8 μM, 10 μM, and 13 μM, respectively. MMPI-1154 is valuable for research applications focused on acute myocardial infarction and other conditions associated with matrix remodeling and cardiovascular protection.

Cat. No.

A76803

CAS No.

161314-17-6

NNGH

NNGH is an inhibitor of stromelysin-1 (MMP-3), a matrix metalloproteinase involved in the regulation of the Wnt/β-catenin signaling pathway. By targeting MMP-3, NNGH disrupts crucial processes associated with tumor progression and metastasis. This reagent is valuable for research applications focused on cancer biology, particularly in studies examining the role of matrix metalloproteinases in tumor dynamics and the associated signaling networks.

Cat. No.

A76804

CAS No.

206549-55-5

MMP-9-IN-9

MMP-9-IN-9 is a selective MMP-9 inhibitor that exhibits a potent inhibitory effect with an IC50 of 5 nM. This compound demonstrates a preferential activity for MMP-9, showing minimal interaction with MMP-1 and MMP-13. MMP-9-IN-9 is noted for its strong anti-inflammatory and neuroprotective properties, making it a valuable tool in research focused on inflammation and neurodegenerative diseases.

Cat. No.

A76805

CAS No.

820223-77-6

PF-00356231 hydrochloride

PF-00356231 hydrochloride is a selective inhibitor of matrix metalloproteinase 12 (MMP-12), exhibiting an IC50 of 1.4 µM. It forms a complex with MMP-12, effectively inhibiting its activity, while also demonstrating potency against other matrix metalloproteinases, including MMP-13 (IC50 = 0.00065 µM), MMP-8 (IC50 = 1.7 µM), MMP-9 (IC50 = 0.98 µM), and MMP-3 (IC50 = 0.39 µM). This compound is valuable in research exploring the roles of MMPs in various pathological conditions, including chronic inflammation and tissue remodeling.

Cat. No.

A76806

CAS No.

1025716-81-7

MMP408

MMP408 is a selective inhibitor of matrix metalloproteinase-12 (MMP-12), exhibiting potent activity with IC50 values of 2 nM, 160 nM, and 3 μM for human, mouse, and rat MMP-12, respectively. It also demonstrates an IC50 value of 120 nM against human MMP-13, while showing limited activity against other matrix metalloproteinases. MMP408 has potential applications in researching inflammation, fibrosis, and tissue remodeling, particularly in the context of chronic obstructive pulmonary disease and chronic sinusitis with nasal polyps.

Cat. No.

A76807

CAS No.

2642181-22-2

TP0597850

TP0597850 is a selective inhibitor of matrix metalloproteinase 2 (MMP2), exhibiting an IC50 value of 0.22 nM. This compound demonstrates a prolonged dissociation half-life of 265 minutes, making it an effective tool for studying MMP2's role in various biological processes. TP0597850 is applicable in research focused on cancer metastasis, tissue remodeling, and inflammatory responses.

Cat. No.

A76808

CAS No.

193807-60-2

BPHA

BPHA is a potent, orally active inhibitor of matrix metalloproteinases MMP-2, MMP-9, and MMP-14, exhibiting IC50 values of 12 nM, 16 nM, and 17 nM, respectively. This compound possesses selectivity for these target enzymes, with no significant inhibition observed for MMP-1, -3, and -7. BPHA demonstrates notable antiangiogenic and antitumor activities, making it a valuable tool for cancer research and studies involving tumor microenvironment modulation.

Cat. No.

A76811

CAS No.

2758892-64-5

ADAM8-IN-1

ADAM8-IN-1 is a selective inhibitor of the ADAM8 metalloproteinase, exhibiting an IC50 value of 73 nM. This compound is recognized for its role in modulating extracellular matrix remodeling and inflammatory processes. ADAM8-IN-1 is valuable for research applications focused on cancer biology, autoimmune diseases, and tissue remodeling, facilitating the study of ADAM8's involvement in various pathological conditions.

Cat. No.

A76812

CAS No.

1772-39-0

MMP2-IN-2

MMP2-IN-2 is a potent and selective inhibitor of MMP-2 (matrix metalloproteinase-2), exhibiting an IC50 of 4.2 μM. Additionally, it demonstrates inhibitory activity against MMP-13, MMP-9, and MMP-8, with IC50 values of 12 μM, 23.3 μM, and 25 μM, respectively. This compound is useful in research applications related to tissue remodeling, cancer metastasis, and inflammatory diseases, making it valuable for studies focused on matrix metalloproteinase regulation.