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E3 Ligase Ligands

E3 ligase ligands bind ubiquitin ligases such as cereblon and von Hippel-Lindau (VHL) in degrader design. In a degrader, they anchor the ligase end of the molecule. E3 ubiquitin ligases transfer ubiquitin to substrate proteins and mark them for degradation by the proteasome. Thalidomide and its analogs bind cereblon (CRBN), a substrate receptor of a cullin-based E3 ligase complex identified as their direct target in 2010. The category includes cereblon ligands such as thalidomide fluoride and TD-106, and VHL ligands such as VL285 and VH032-cyclopropane-F. These ligands are used to build proteolysis-targeting chimeras (PROTACs) and to study how ligases are recruited to new substrates.

Cat. No.

A80672

CAS No.

1547163-08-5

Pomalidomide-6-O-CH3

Pomalidomide-6-O-CH3 is a modified derivative of Pomalidomide that serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound plays a crucial role in the recruitment of CRBN, facilitating targeted protein degradation through the formation of PROTACs when linked to other protein ligands. Its application in the study of protein turnover and degradation pathways makes it a valuable tool in chemical biology and therapeutic research.

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25 mg

$1,275.00

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Cat. No.

A80673

CAS No.

2154341-52-1

E3 ligase Ligand 29

E3 Ligase Ligand 29 serves as a ligand for E3 ligases, facilitating the ubiquitination process by targeting specific substrates for proteasomal degradation. This compound plays a crucial role in modulating cellular protein levels and has significant applications in research focused on protein homeostasis, cancer biology, and signal transduction pathways. The ability to selectively influence E3 ligase activity makes it a valuable tool for studying ubiquitin-mediated mechanisms.

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Cat. No.

A80674

CAS No.

3027839-56-8

Dihydrouracil-Ph-2-Me-piperidine

Dihydrouracil-Ph-2-Me-piperidine serves as a ligand for E3 ligase, facilitating targeted protein degradation through the PROTAC technology. It is instrumental in synthesizing the PROTAC HPK1 Degrader-6, which can be employed in studies aimed at modulating cellular pathways by specifically degrading target proteins. This compound is valuable for researchers investigating the therapeutic potential of PROTACs and E3 ligase-mediated protein degradation in various biological contexts.

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Cat. No.

A80675

CAS No.

2825005-43-2

Thalidomide-C4-N2-C2-N3

Thalidomide-C4-N2-C2-N3 is a potent E3 ligase ligand that facilitates the formation of PROTAC molecules. This compound is designed to bind to target protein ligands through a flexible linker, enabling the degradation of specific substrates such as sEH via the PROTAC mechanism. Its ability to modulate protein levels provides valuable utility in research applications focused on targeted protein degradation and therapeutic potential in various disease contexts.

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Cat. No.

A80676

CAS No.

3036607-12-9

CRBN ligand-181

CRBN ligand-181 is an E3 ubiquitin ligase ligand designed to engage the cereblon (CRBN) target. This compound serves as a key building block for the development of proteolysis-targeting chimeras (PROTACs), enabling targeted degradation of specific proteins within cellular systems. Its application in research facilitates the study of targeted protein degradation and modulation of cellular pathways.

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Cat. No.

A80677

CAS No.

1135008-81-9

CRBN ligand-200

CRBN ligand-200 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (Proteolysis Targeting Chimera), enabling targeted degradation of specific proteins. Research applications include studying protein turnover processes and developing novel therapeutic strategies in targeted protein degradation.

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Cat. No.

A80678

CAS No.

2925099-70-1

CRBN ligand-625

CRBN ligand-625 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of CRBN to specific target proteins. This compound can be utilized in the development of proteolysis-targeting chimeras (PROTACs), enabling the selective degradation of proteins of interest. CRBN ligand-625 is essential for research in targeted protein degradation and protein homeostasis studies.

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Cat. No.

A80679

CAS No.

2925089-05-8

CRBN ligand-363

CRBN ligand-363 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to target protein ligands through a linker to create PROTACs, enabling targeted protein degradation. It serves as a valuable tool in research applications involving protein modulation and degradation pathways.

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Cat. No.

A80680

CAS No.

2925096-64-4

CRBN ligand-557

CRBN ligand-557 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in conjunction with a target protein ligand via a linker to create proteolysis-targeting chimeras (PROTACs). It serves a crucial role in targeted protein degradation research, enabling the study of protein modulation and therapeutic interventions in various biological contexts.

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Cat. No.

A80681

CAS No.

3027830-64-1

CRBN ligand-202

CRBN ligand-202 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in cellular systems. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera) to effectively promote targeted protein degradation. Its application in research supports the exploration of targeted protein modulation and therapeutic strategies in various biological contexts.

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Cat. No.

A80682

CAS No.

2925081-35-0

CRBN ligand-436

CRBN ligand-436 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the development of PROTACs (proteolysis-targeting chimeras) by linking it to a target protein ligand through a suitable linker. Its application includes targeted protein degradation studies, providing an innovative approach for modulating protein levels in various biological contexts.

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Cat. No.

A80683

CAS No.

2925082-50-2

CRBN ligand-694

CRBN Ligand-694 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. This compound can be conjugated with a target protein ligand through a linker to create a PROTAC (Proteolysis Targeting Chimera), enabling targeted protein degradation. Its applications are valuable in chemical biology and therapeutic research, particularly in the study of protein modulation and the ubiquitin-proteasome system.

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Cat. No.

A80684

CAS No.

2925093-08-7

CRBN ligand-448

CRBN ligand-448 is a ligand for the E3 ubiquitin ligase known as cereblon (CRBN). This compound facilitates the recruitment of cereblon, allowing for targeted protein degradation by forming a proteolysis-targeting chimeric (PROTAC) molecule when conjugated to a target protein ligand via a linker. Its utility in research includes investigating protein turnover and the modulation of cellular signaling pathways.

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Cat. No.

A80685

CAS No.

2925102-76-5

CRBN ligand-333

CRBN Ligand-333 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This chemical compound is designed to be conjugated with a target protein ligand through a linker, enabling the formation of proteolysis-targeting chimeras (PROTACs). Its application in targeted protein degradation research offers significant potential for therapeutic intervention and advancing drug discovery initiatives.

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Cat. No.

A80686

CAS No.

2925100-78-1

CRBN ligand-253

CRBN ligand-253 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). CRBN ligand-253 is primarily utilized in research applications focused on targeted protein degradation and the modulation of protein levels within cellular contexts.

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Cat. No.

A80687

CAS No.

2925102-84-5

CRBN ligand-332

CRBN ligand-332 is a novel ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of the CRBN protein, allowing for targeted protein degradation applications. CRBN ligand-332 can be conjugated to a target protein ligand through a linker to create a PROTAC, making it a valuable tool for studying protein function and regulation in chemical biology and drug discovery.

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Cat. No.

A80688

CAS No.

2925095-11-8

CRBN ligand-348

CRBN ligand-348 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein for targeted protein degradation. This compound can be utilized to conjugate with a target protein ligand through a linker, enabling the formation of PROTAC molecules. Its application is particularly relevant in drug discovery and development, particularly for studies involving targeted protein degradation mechanisms.

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Cat. No.

A80689

CAS No.

2413039-23-1

CRBN ligand-211

CRBN ligand-211 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound serves as a crucial component for the development of proteolysis-targeting chimeras (PROTACs) by linking to target protein ligands through a suitable linker. It is valuable for research in targeted protein degradation and cellular regulation studies.

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Cat. No.

A80690

CAS No.

2698398-71-7

Desamino lenalidomide-Bpin

Desamino lenalidomide-Bpin is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this critical protein for targeted protein degradation applications. Its chemical structure enables the conjugation of Desamino lenalidomide-Bpin to a target protein ligand via a linker, forming a proteolysis-targeting chimera (PROTAC). This compound is essential for research in areas such as targeted therapy and degradation of disease-related proteins.

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Cat. No.

A80691

CAS No.

2616539-63-8

Desamino lenalidomide[3,4-g]piperidine

Desamino lenalidomide[3,4-g]piperidine is a ligand for the E3 ubiquitin ligase cereblon (CRBN), playing a critical role in targeted protein degradation. This compound facilitates the recruitment of the cereblon protein, enabling the design of bifunctional therapeutic molecules when linked to a target protein ligand through a suitable linker. It serves as a valuable tool in research applications focused on the modulation of protein homeostasis and therapeutic strategies against various diseases.

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Cat. No.

A80692

CAS No.

2925092-81-3

CRBN ligand-351

CRBN ligand-351 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN). It effectively recruits the cereblon protein and can be conjugated to a target protein ligand through a linker, facilitating the formation of a PROTAC (Proteolysis Targeting Chimera). This compound is valuable for research applications focused on targeted protein degradation and modulation of cellular pathways.

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Cat. No.

A80693

CAS No.

2243825-20-7

(R)-Desamino lenalidomide-5-Br

(R)-Desamino lenalidomide-5-Br is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein in cellular contexts. This compound can be utilized in the design of PROTACs (proteolysis targeting chimeras) by linking it to a target protein ligand through a suitable linker. Its unique mechanism allows for targeted protein degradation, making it valuable for research applications in drug discovery and therapeutic development.

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5 mg

$30.00

10 mg

$50.00

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Cat. No.

A80694

CAS No.

2925089-81-0

CRBN ligand-504

CRBN ligand-504 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the development of proteolysis-targeting chimeras (PROTACs). It is a valuable tool in chemical biology for studying targeted protein degradation and ubiquitination processes.

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Cat. No.

A80695

CAS No.

2925072-94-0

CRBN ligand-604

CRBN ligand-604 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of cereblon for targeted protein degradation. It can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). This reagent is instrumental in research applications focused on exploring novel therapeutic strategies for modulating protein levels and identifying potential drug targets.

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Cat. No.

A80696

CAS No.

2925093-30-5

CRBN ligand-495

CRBN ligand-495 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of cereblon to specific target proteins. This compound can be utilized in the construction of PROTACs (proteolysis-targeting chimeras) by linking it to a target protein ligand via an appropriate linker. The application of CRBN ligand-495 offers significant potential in targeted protein degradation studies and therapeutic development within cellular and molecular biology research.

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