Catalog No.
Product Name
Application
Product Information
Citations
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Ligand for E3 Ligase
CRBN ligand-291 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), functioning by selectively recruiting the CRBN protein. It serves as a valuable component in the construction of PROTACs (proteolysis-targeting chimeras) when linked to a target protein ligand via a suitable linker. This compound is essential for studies focused on targeted protein degradation and elucidating cellular mechanisms involving the ubiquitin-proteasome system. -
Ligand for E3 Ligase
CRBN ligand-379 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand using a linker to create a PROTAC, enabling targeted protein degradation. Its applications in drug discovery and cellular research make it an invaluable tool for studying protein homeostasis and therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-388 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC, enabling selective degradation of specific proteins in cellular contexts. It serves as a valuable tool in research applications focused on targeted protein degradation and modulating protein levels within various biological systems. -
Ligand for E3 Ligase
CRBN ligand-526 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be employed in the development of PROTACs (proteolysis targeting chimeras) by linking it to a target protein ligand through a suitable linker. Research applications include targeted protein degradation studies, enabling the exploration of novel therapeutic strategies in various disease models. -
Ligand for E3 Ligase
CRBN ligand-610 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein to target proteins. This compound can be conjugated to a target protein ligand through a linker, enabling the development of PROTACs (proteolysis-targeting chimeras) for targeted protein degradation applications. It is a valuable tool for researchers studying ubiquitin-proteasome pathway modulation and targeted therapeutics. -
Ligand for E3 Ligase
CRBN ligand-258 is a ligand specifically designed for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of cereblon to target proteins, enabling the formation of targeted protein degradation chimeras (PROTACs) when linked with an appropriate target ligand. It serves as a valuable tool in drug discovery and development by promoting the ubiquitin-proteasome pathway for selective protein degradation. -
Ligand for E3 Ligase
CRBN ligand-360 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). It is suitable for applications in targeted protein degradation research and studies involving ubiquitin-proteasome system modulation. -
Ligand for E3 Ligase
CRBN ligand-347 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It effectively recruits the cereblon protein, facilitating the targeted degradation of proteins through the proteasome pathway. This compound is commonly employed in PROTAC (proteolysis-targeting chimera) applications, allowing researchers to develop bifunctional molecules that selectively degrade specific target proteins in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-316 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound is particularly useful in the development of Proteolysis Targeting Chimeras (PROTACs) by linking to target protein ligands through a suitable linker. Its application in targeted protein degradation makes it a valuable tool in chemical biology and therapeutic research. -
Ligand for E3 Ligase
CRBN ligand-752 is a ligand specifically designed for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). Its application in targeted protein degradation research offers valuable insights into cell signaling and disease mechanisms. -
Ligand for E3 Ligase
CRBN ligand-362 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound serves as a crucial component in the development of PROTACs (proteolysis-targeting chimeras), enabling targeted protein degradation. Its application is vital for research into targeted therapies and the modulation of protein levels in cellular contexts. -
Ligand for E3 Ligase
CRBN ligand-768 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker to create a Proteolysis Targeting Chimera (PROTAC). It serves as a valuable tool in the study of targeted protein degradation and has potential applications in drug discovery and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-705 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound effectively recruits the CRBN protein and can be utilized to create peptide-hybrid PROTACs when linked to a target protein ligand through a suitable linker. Its application in protein degradation research provides valuable insights into targeted protein modulation and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-353 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in the design of PROTACs (Proteolysis Targeting Chimeras) by covalently linking it to a target protein ligand via a suitable linker. It is valuable in studies focused on targeted protein degradation and modulation of cellular pathways mediated by ubiquitination. -
Ligand for E3 Ligase
CRBN ligand-378 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to target protein ligands through a linker, enabling the formation of proteolysis-targeting chimeras (PROTACs). It is valuable for research applications focused on targeted protein degradation and modulation of cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-599 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in the design of proteolysis-targeting chimeras (PROTACs) by linking it to specific target protein ligands through a suitable linker. Its applications include studying targeted protein degradation mechanisms and potential therapeutic interventions in protein homeostasis-related diseases. -
Ligand for E3 Ligase
CRBN ligand-595 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). CRBN ligand-595 is valuable for studies in targeted protein degradation and E3 ligase-mediated ubiquitination pathways. -
Ligand for E3 Ligase
CRBN ligand-622 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC). Its use in research enables the selective degradation of specific proteins, thereby aiding investigations into protein regulation and therapeutic applications. -
Ligand for E3 Ligase
CRBN ligand-787 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. This compound can be utilized in the development of proteolysis-targeting chimeras (PROTACs) by linking it to a ligand for the target protein, enabling targeted degradation via the ubiquitin-proteasome system. CRBN ligand-787 is valuable in research applications focused on protein regulation and degradation mechanisms. -
Protein Ligand
Phenyl-glutarimide 4'-oxyacetic acid is a carboxylic acid-functionalized ligand targeting proteins involved in PROTAC (Proteolysis Targeting Chimeras) pathways. This compound exhibits enhanced hydrolytic stability and efficacy when interacting with PROTACs, making it a valuable tool for researchers developing PROTAC deactivators. Its distinct binding properties facilitate investigations into protein degradation mechanisms and associated signaling pathways. -
Ligand for E3 Ligase
CRBN ligand-720 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to generate a PROTAC (proteolysis-targeting chimeras), enabling targeted protein degradation. It is useful in research applications involving ubiquitin-proteasome system modulation and has potential implications in therapeutic discovery. -
Ligand for E3 Ligase
CRBN ligand-210 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker, thereby enabling the construction of a PROTAC. Such applications are valuable for targeted protein degradation studies, offering insights into protein function and regulation in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-537 is a specific ligand for the E3 ubiquitin ligase, cereblon (CRBN). It facilitates the recruitment of CRBN to target proteins, enabling targeted protein degradation through the formation of proteolysis-targeting chimeras (PROTACs). This compound is valuable in research applications focused on investigating protein ubiquitination and degradation pathways. -
Ligand for E3 Ligase
CRBN ligand-365 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling targeted protein degradation via the ubiquitin-proteasome system. This compound serves as a crucial component for the development of PROTACs (Proteolysis Targeting Chimeras) by facilitating the recruitment of CRBN to a specific target protein. This functionality makes CRBN ligand-365 a valuable tool for investigating protein homeostasis and therapeutic interventions in various biological pathways and diseases. -
Ligand for E3 Ligase
CRBN ligand-693 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN to specific target proteins, enabling the formation of PROTACs (proteolysis-targeting chimeras). It is suitable for use in research applications focused on targeted protein degradation and the modulation of protein levels within various cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-433 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of the CRBN protein, enabling the design of Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation. This compound is valuable for research applications focused on understanding cellular protein regulation and developing novel therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-299 serves as an E3 ubiquitin ligase ligand that selectively recruits the cereblon (CRBN) protein. This compound can be utilized to conjugate with target protein ligands through a linker, facilitating the development of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation studies. As such, it is valuable for research focused on modulating protein levels and studying cellular processes influenced by ubiquitination pathways. -
Thalidomide Analog
5-Hydroxy-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindole-1,3-dione is a Thalidomide analog that possesses a hydroxy group allowing for potential derivatization. This compound functions as an E3 ligase activator, facilitating the ubiquitinylation of target proteins. Its biological activity makes it valuable for research in drug development, particularly in studies focused on protein degradation and cellular signaling pathways. -
Ligand for E3 Ligase
CRBN ligand-306 is a ligand designed for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized to connect with target protein ligands through a linker, forming a proteolysis-targeting chimera (PROTAC). Its applications include targeted protein degradation research, offering a pathway for studying and modulating protein levels in cellular systems. -
Ligand for E3 Ligase
CRBN ligand-890 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of CRBN for targeted protein degradation. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis targeting chimera) for selective degradation of proteins of interest. Its application in research includes investigations into protein homeostasis and therapeutic strategies for diseases linked to aberrant protein levels. -
Ligand for E3 Ligase
CRBN ligand-630 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be effectively coupled with target protein ligands via a linker to create a proteolysis-targeting chimera (PROTAC). CRBN ligand-630 is valuable in studies of targeted protein degradation and the modulation of cellular processes through ubiquitin-mediated pathways. -
Ligand for E3 Ligase
CRBN ligand-346 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). CRBN ligand-346 is instrumental in studies involving targeted protein degradation, offering insights into mechanisms of action in cellular processes and potential therapeutic applications. -
Ligand for E3 Ligase
CRBN ligand-736 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized in the construction of PROTACs (Proteolysis Targeting Chimeras) by linking it to a target protein ligand through a linker. CRBN ligand-736 serves as a valuable tool for studies involving targeted protein degradation and therapeutic development in cancer and other diseases. -
Ligand for E3 Ligase
CRBN ligand-586 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein in targeted protein degradation applications. This compound can be conjugated with a target-specific ligand through a suitable linker to create a PROTAC, enabling the degradation of proteins of interest. CRBN ligand-586 is valuable for research in the fields of cancer biology and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-490 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). CRBN ligand-490 is valuable for studies in targeted protein degradation and therapeutic research applications related to modulating cellular protein levels. -
Ligand for E3 Ligase
CRBN ligand-479 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of CRBN to target proteins. This compound can be conjugated to a specific target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimeric (PROTAC) molecule. CRBN ligand-479 is essential for studies in targeted protein degradation and has applications in drug discovery and development. -
Ligand for E3 Ligase
CRBN ligand-457 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound serves as a valuable tool for the development of PROTACs by linking CRBN to target protein ligands through a suitable linker. Its utility in targeted protein degradation research makes it an essential reagent for studies in drug discovery and cellular biology. -
E3 Ligase Activator
5-Bromomethylthalidomide is an E3 ligase activator that facilitates protein ubiquitination, thereby influencing protein stability and degradation pathways. This compound serves as a key tool in research focused on targeted protein degradation and cellular regulation mechanisms. Its potential for further derivatization through bromide substitution enhances its utility in chemical biology and therapeutic research. -
Ligand for E3 Ligase
CRBN ligand-658 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN in cellular systems. It is designed for the development of proteolysis-targeting chimeras (PROTACs) by linking to target protein ligands via a suitable linker. This compound is useful in investigating ubiquitin-proteasome pathway mechanisms and advancing targeted protein degradation research. -
Ligand for E3 Ligase
CRBN ligand-513 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of the CRBN protein. This compound can be utilized in the development of proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through a suitable linker. Its primary application lies in targeted protein degradation studies, contributing to research on cellular regulation and therapeutic development. -
Ligand for E3 Ligase
(R,S,R)-AHPC-NHBoc is a ligand for the E3 ubiquitin ligase VHL that facilitates the recruitment of the VHL protein. This compound can be utilized to construct PROTACs by linking it to a target protein ligand through a suitable linker. Its ability to modulate protein degradation pathways makes it a valuable tool for research in targeted protein degradation and related therapeutic applications. -
Ligand for E3 Ligase
CRBN ligand-763 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker to generate a PROTAC (proteolysis-targeting chimera), enabling targeted protein degradation. It serves as a valuable tool in drug discovery and therapeutic research aimed at modulating protein levels within cells. -
Ligand for E3 Ligase
CRBN ligand-236 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN to target proteins, enabling the development of proteolysis-targeting chimeras (PROTACs). CRBN ligand-236 serves as a valuable tool for studying protein degradation pathways and exploring new therapeutic strategies in cellular biology and drug discovery. -
Ligand for E3 Ligase
CRBN ligand-628 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to effectively recruit the CRBN protein. It can be utilized to conjugate with a target protein ligand through a linker, facilitating the formation of PROTACs (proteolysis-targeting chimeras). This compound serves as a valuable tool in targeted protein degradation research, enabling the investigation of protein function and regulation in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-521 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this essential protein. It can be conjugated to a target protein ligand through a linker to create a PROTAC, enabling targeted protein degradation. This reagent is valuable for research applications in drug discovery and development, particularly in the study of protein homeostasis and therapeutic intervention. -
Ligand for E3 Ligase
CRBN ligand-358 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the development of PROTACs by linking it to a target protein ligand through a suitable linker, enabling targeted protein degradation. Its applications in chemical biology research include studying protein homeostasis and dissecting cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-671 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN to target proteins, enabling the development of targeted protein degradation strategies through the formation of PROTACs (Proteolysis Targeting Chimeras). CRBN ligand-671 is instrumental in research applications focusing on protein regulation and cellular signaling pathways. -
Ligand for E3 Ligase
CRBN ligand-439 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN for targeted protein degradation. This compound can be conjugated to a target protein ligand through a linker to form a PROTAC, enabling the modulation of protein levels and function in various biological contexts. It serves as a valuable tool for researchers investigating targeted protein degradation pathways and the role of CRBN in cellular processes. -
Ligand for E3 Ligase
CRBN ligand-657 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the development of PROTACs by linking it to a target protein ligand through a suitable linker. CRBN ligand-657 is valuable for investigating the mechanisms of targeted protein degradation and exploring therapeutic possibilities in various diseases. -
Ligand for E3 Ligase
CRBN ligand-343 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), functioning primarily to recruit the CRBN protein. This compound can be conjugated to target protein ligands through a linker, facilitating the formation of PROTACs (proteolysis-targeting chimeras). It is valuable in research applications focused on targeted protein degradation and modulation of cellular protein levels, contributing to novel therapeutic strategies.
