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E3 ligase ligands bind ubiquitin ligases such as cereblon and von Hippel-Lindau (VHL) in degrader design. In a degrader, they anchor the ligase end of the molecule. E3 ubiquitin ligases transfer ubiquitin to substrate proteins and mark them for degradation by the proteasome. Thalidomide and its analogs bind cereblon (CRBN), a substrate receptor of a cullin-based E3 ligase complex identified as their direct target in 2010. The category includes cereblon ligands such as thalidomide fluoride and TD-106, and VHL ligands such as VL285 and VH032-cyclopropane-F. These ligands are used to build proteolysis-targeting chimeras (PROTACs) and to study how ligases are recruited to new substrates.
Hydrouracil-4-benzazimide-7-NH2 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand using a linker, enabling the construction of proteolysis targeting chimeras (PROTACs). It is of particular interest in pharmacological research for its potential to modulate protein degradation pathways.
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Desamino lenalidomide-5-acetonitrile is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in targeted protein degradation. This compound can be conjugated to a target protein ligand using a linker to create a PROTAC, enabling the selective degradation of specific proteins. Its applications in chemical biology and therapeutics make it a valuable tool for studying protein regulation and developing innovative treatments.
CRBN ligand-345 is an E3 ubiquitin ligase ligand that specifically targets cereblon (CRBN). This compound is utilized to facilitate the recruitment of the CRBN protein, thereby enabling targeted protein degradation through the formation of PROTACs when linked to a target protein ligand via a suitable linker. Its application is significant in investigating the dynamics of protein turnover and elucidating cellular processes involving ubiquitination.
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CRBN ligand-231 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized to create a PROTAC (Proteolysis Targeting Chimeras) by linking it to a target protein ligand through a suitable linker. CRBN ligand-231 is instrumental in research applications focused on targeted protein degradation and the study of ubiquitin-proteasome pathway mechanisms.
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CRBN ligand-461 is an E3 ubiquitin ligase ligand that specifically targets cereblon (CRBN). It facilitates the recruitment of the CRBN protein and can be utilized to form a PROTAC by linking to a target protein ligand through a suitable linker. This compound is instrumental in studies involving targeted protein degradation and has potential applications in drug discovery and development.
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CRBN ligand-303 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. Its ability to be conjugated with a target protein ligand through a linker allows for the development of PROTACs, enabling targeted protein degradation. This compound is instrumental in studying protein regulation and exploring therapeutic applications in cancer and other diseases.
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CRBN ligand-563 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in the design of PROTACs (proteolysis-targeting chimeras) by linking it with target protein ligands via a suitable linker. Its applications include targeted protein degradation studies and exploring novel therapeutic strategies in various diseases.
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CRBN ligand-587 is a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN to target proteins, allowing for the targeted degradation of these proteins through the PROTAC (Proteolysis Targeting Chimeras) pathway. CRBN ligand-587 is instrumental in research applications focusing on protein modulation and targeted protein degradation strategies.
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CRBN ligand-201 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized to link with target protein ligands through a suitable linker, enabling the formation of proteolysis-targeting chimeras (PROTACs). Its application is primarily in the fields of targeted protein degradation and drug discovery, offering insights into cellular regulation and therapeutic interventions.
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CRBN ligand-635 is an E3 ubiquitin ligase ligand specifically designed to interact with cereblon (CRBN). This compound facilitates the recruitment of the CRBN protein, enabling targeted protein degradation by forming a PROTAC when conjugated with a target protein ligand through a linker. The biological activity of CRBN ligand-635 makes it valuable for research applications focused on protein homeostasis and novel therapeutic strategies in cellular and molecular biology.
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CRBN ligand-713 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein for targeted protein degradation. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). CRBN ligand-713 serves as a valuable tool in chemical biology for studying protein regulation and potential therapeutic applications in targeted degradation strategies.
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CRBN ligand-373 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein to target proteins. This compound is designed to be covalently linked to target protein ligands through a linker, enabling the formation of proteolysis-targeting chimeras (PROTACs). Its application in targeted protein degradation research offers valuable insights into cellular processes and therapeutic interventions.
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CRBN ligand-633 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN to target proteins, enabling the formation of proteolysis-targeting chimeras (PROTACs) when linked to specific target protein ligands through a suitable linker. This compound is instrumental in modulating protein degradation pathways for research in drug development and targeted cancer therapies.
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CRBN ligand-580 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (Proteolysis Targeting Chimeras), enabling targeted protein degradation. Its applications include insights into protein regulation mechanisms and drug discovery processes.
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CRBN ligand-296 is a ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN to target proteins, enabling targeted protein degradation through PROTAC (Proteolysis Targeting Chimeras) technology. This compound is valuable for research applications focused on ubiquitin-mediated proteolysis and the development of novel therapeutic strategies for various diseases.
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CRBN ligand-393 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. It can be effectively linked to target protein ligands through a suitable linker to create a PROTAC, enabling targeted protein degradation. This compound is valuable for research applications focused on therapeutic interventions in cellular processes mediated by protein homeostasis.
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CRBN ligand-555 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the synthesis of a PROTAC (proteolysis-targeting chimera). CRBN ligand-555 serves as a valuable tool in studies of targeted protein degradation and has applications in the development of novel therapeutic strategies for various diseases.
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(S,S,S)-AHPC-Me is a ligand for E3 ligases, playing a crucial role in targeted protein degradation pathways. This compound facilitates the synthesis of PROTACs, specifically the (4S)-PROTAC SOS1 degrader-1 diTFA. Its efficacy in modulating E3 ligase activity makes it valuable for research applications in cellular signaling and therapeutic development.
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Thalidomide-4-OH-(S)-CH3 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of cereblon to target proteins, enabling the formation of PROTACs (proteolysis-targeting chimeras) when linked to target protein ligands via appropriate linkers. Its ability to modulate protein degradation pathways makes it valuable for research applications in targeted protein degradation and therapeutic development.
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CRBN ligand-528 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). It serves as a molecular tool to recruit the CRBN protein, facilitating targeted protein degradation when conjugated to a target protein ligand through a suitable linker. This compound is essential for research applications focused on understanding ubiquitin-mediated proteolysis and developing PROTAC (Proteolysis Targeting Chimera) strategies for therapeutic intervention.
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CRBN ligand-413 is an E3 ubiquitin ligase ligand that specifically targets cereblon (CRBN). This compound facilitates the recruitment of the CRBN protein and can be utilized in the development of PROTACs by linking it to a target protein ligand through a suitable linker. Its applications are significant in studying targeted protein degradation and the modulation of protein levels within cellular contexts.
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CRBN ligand-264 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling targeted recruitment of the CRBN protein. This compound is instrumental in the development of proteolysis-targeting chimeras (PROTACs) by linking to target protein ligands through a suitable linker, facilitating selective degradation of proteins in cellular environments. Its application in research may enhance studies related to protein regulation and therapeutic interventions targeting protein homeostasis.
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CRBN ligand-271 is a targeted ligand for the E3 ubiquitin ligase cereblon (CRBN). It functions by recruiting the cereblon protein, enabling the formation of PROTACs (proteolysis-targeting chimeras) when linked to a specific target protein ligand through a suitable linker. This compound is valuable for studies involving targeted protein degradation and cellular regulation, assisting researchers in exploring novel therapeutic approaches in cancer and other diseases.
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CRBN ligand-659 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a suitable linker, enabling the development of PROTACs (proteolysis-targeting chimeras). Its utility in research lies in targeted protein degradation and the modulation of cellular pathways, making it a valuable tool for studying protein function and therapeutic interventions.
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CRBN ligand-634 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN to target proteins, making it a vital component in the design of proteolysis-targeting chimeras (PROTACs). This reagent is suitable for studies aimed at investigating targeted protein degradation and its therapeutic potential in various diseases.
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