Name: DUB-IN-7
Brand: Adooq Bioscience
SKU: A54565
Rating: 5 (288 reviews)

Catalog No.

Product Name

Application

Product Information

Citations

A15391

b-AP15 (NSC 687852)

DUB inhibitor

NSC 687852 is an inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), two proteasome-associated DUBs.
- Anurag Rathore, .et al. , Sci Rep, 2020, 10: 5350 PMID: 32210344
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A18780

GRL0617

SARS PLPro inhibitor

GRL0617 is a potent, selective and competitive noncovalent inhibitor of SARS PLPro, with an IC50 of 0.6 μM, and with a Ki of 0.49 μM.
- GuanQun Liu, .et al. , Nat Microbiol, 2021, Apr;6(4):467-478 PMID: 33727702
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A10988

WP1130 (Degrasyn)

DUB/Bcr/ABL Inhibitor

WP1130 (Degrasyn) is a novel selective small molecular deubiquitinase inhibitor and a Bcr/Abl destruction pathway activator that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells.
- Kevin Bohm, .et al. , Arch Pharm (Weinheim), 2023, Jul;356(7):e2200661 PMID: 37196427
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A13352

HBX 41108

USP 7 inhibitor

HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM).
- Kevin Bohm, .et al. , Arch Pharm (Weinheim), 2023, Jul;356(7):e2200661 PMID: 37196427
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A20371

ML364

USP2 inhibitor

ML364 is a selective ubiquitin specific peptidase 2 (USP2) inhibitor (IC50=1.1 μM) with anti-proliferative activity.
- Kevin Bohm, .et al. , Arch Pharm (Weinheim), 2023, Jul;356(7):e2200661 PMID: 37196427
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A15238

SJB2-043

USP1 Inhibitor

SJB2-043 is one of analogs/derivatives of C527, which is a novel and potent USP1 (ubiquitin-specific protease 1) inhibitor.
- Kevin Bohm, .et al. , Arch Pharm (Weinheim), 2023, Jul;356(7):e2200661 PMID: 37196427
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A13209

IU1

Usp14 inhibitor

IU1 is a selective inhibitor of Usp14. It inhibits the catalytic activity of proteasome-associated Usp14 in vitro (IC50 < 4 uM).
- Kevin Bohm, .et al. , Arch Pharm (Weinheim), 2023, Jul;356(7):e2200661 PMID: 37196427
- Anurag Rathore, .et al. , Sci Rep, 2020, 10: 5350 PMID: 32210344
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A13190

PR-619

DUB inhibitor

PR-619 is a cell-permeable, reversible, and broad-spectrum inhibitor of the deubiquitinylating enzymes (DUBs).
- Yu Zhu, .et al. , Plant Cell, 2026, Jul 2;38(7):koag187 PMID: 42299846
- Anurag Rathore, .et al. , Sci Rep, 2020, 10: 5350 PMID: 32210344
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A16740

TCID

UCH-L3 inhibitor

TCID (4,5,6,7-Tetrachloroindan-1,3-dione) is a potent and selective inhibitor of neuronal ubiquitin C-terminal hydrolase UCH-L3, with an IC50 of 0.6 μM. It reduces ubiquitination of the glycine transporter GlyT2 in primary neurons from the brainstem and spinal cord, making it a valuable tool for studying neuronal ubiquitin regulation and glycinergic neurotransmission.

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A12573

NSC632839

isopeptidase inhibitor

NSC632839 is a nonselective isopeptidase inhibitor, which inhibits USP2, USP7, and SENP2 with EC50s of 45??4 μM, 37??1 μM, and 9.8??1.8 μM, respectively.

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A12715

LDN-57444

UCH-L1 Inhibitor

LDN-57444 is a potent, reversible, competitive and active site-directed inhibitor of UCHL1.

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A12813

USP7-IN-1

USP7 inhibitor

USP7-IN-1 is a novel selective and reversible inhibitor of USP7 with IC50 of 33 uM; less or no inhibition on USP5, USP8, Uch-L1, Uch-L3 and Caspase(IC50>200 uM); HCT116 cell viability GI50 is 67 uM.

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A12822

SJB3-019A

USP1 inhibitor

SJB3-019A is a potent and novel usp1 inhibitor. SJB3-019A (IC50 = 0.0781 uM) was 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells.

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A12827

DUBs-IN-1

USP7/USP8 inhibitor

DUBs-IN-1 is a potent deubiquitinase enzyme inhibitor with IC50s of 18 uM/0.71 uM for USP7/USP8 respectively.

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A12830

DUBs-IN-3

USP7/USP8 inhibitor

DUBs-IN-3 is a potent deubiquitinase enzyme inhibitor with IC50s of 3.1 uM for USP8; >30 fold selectivity over USP7 (IC50 > 100 uM).

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A12842

DUB-IN-2

USP7/USP8 inhibitor

DUBs-IN-2 is a potent deubiquitinase enzyme inhibitor with IC50s of 7.2 uM/0.93 uM for USP7/USP8 respectively.

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A12933

P 22077

USP7 inhibitor

P 22077 is a cell-permeable inhibitor of the ubiquitin-specific protease (IC?? = 8.6 μM) and the closely related deubiquitinase (DUB) USP47.

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A13277

P005091

DUB/USP7 Inhibitor

P005091 is a selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 uM).

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A14030

ML-323

USP1-UAF1 inhibitor

ML323 is a selective and highly potent USP1-UAF1 inhibitor links deubiquitination to DNA damage responses.

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A16853

VLX1570

DUB inhibitor

VLX1570 is a competitive inhibitor of proteasome DUB activity, with an IC50 of ~10?μM in vitro.

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A16883

GNE-6640

USP7 inhibitor

GNE-6640 is a novel selective USP7 inhibitor, inducing tumor cell death. GNE-6640 enhances cytotoxicity with chemotherapeutic agents and targeted compounds, including PIM kinase inhibitors.

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A22407

RA-9

proteasome-associated deubiquitinating enzymes inhibitor

RA-9 is a potent and selective proteasome-associated deubiquitinating enzymes (DUBs) inhibitor with favorable toxicity profile and anticancer activity.

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A22475

XL177A

USP7 inhibitor

XL177A is a potent USP7 inhibitor that irreversibly inhibits USP7 with sub-nM potency and selectivity across the human proteome.

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A21049

HBX 19818

USP7 inhibitor

HBX 19818 is a specific inhibitor of ubiquitin-specific protease 7 (USP7), with an IC50 of 28.1 μM.

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A21365

C527

pan DUB enzyme inhibitor

C527 is a is a pan DUB enzyme inhibitor, with a high potency for the USP1/UAF1 complex (IC50=0.88 μM).

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A21484

USP7/USP47 inhibitor

USP7/USP47 inhibitor

USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM, respectively.

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A20166

EOAI3402143

DUB inhibitor

EOAI3402143 is a deubiquitinase (DUB) inhibitor, which inhibits dose-dependently inhibits Usp9x/Usp24 and Usp5.

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A20262

USP7-IN-3

USP7 inhibitor

USP7-IN-3 (Compound 5) is a potent and selective allosteric ubiquitin-specific protease 7 (USP7) inhibitor.

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A18615

IU1-47

USP14 inhibitor

IU1-47 is a potent and specific USP14 inhibitor with an IC50 of 0.6 μM. IU1-47 inhibits IsoT/USP5 with an IC50 of 20 μM. IU1-47 induces tau elimination in cultured neurons.

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A18711

AZ1

USP25/28 inhibitor

AZ1 is a dual inhibitor of the USP25/28 deubiquitinating enzyme subfamily.

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A19256

FT827

USP7 inhibitor

FT827 is a selective and covalent ubiquitin-specific protease 7 (USP7) inhibitor (Ki=4.2 ?M). FT827 binds to the USP7 catalytic domain (USP7CD; residues 208-560) with an apparent Kd value of 7.8 ?M.

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A19260

MF-094

USP30 inhibitor

MF-094 is a potent and selective USP30 inhibitor with an IC50 of 120 nM. MF-094 increases protein ubiquitination and accelerates mitophagy.

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A19439

GNE-6776

USP7 inhibitor

GNE-6776 is a selective USP7 inhibitor.

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A19451

FT671

USP7 inhibitor

FT671 is a potent, non-covalent and selective USP7 inhibitor with an IC50 of 52 nM and binds to the USP7 catalytic domain with a Kd of 65 nM.

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A15321

Vialinin A

USP4 Inhibitor

Vialinin A is a terphenyl compound originally isolated from the fungi T. terrestris and T. vialis.

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A54565

DUB-IN-7

DUB Inhibitor

DUB-IN-7 is a potent deubiquitinating enzyme (DUB) inhibitor. This compound selectively targets DUBs, facilitating the investigation of their role in various biological processes. DUB-IN-7 is particularly relevant for research into diseases associated with dysregulated JAK2 activity, including leukemia.

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