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PTH1R agonists and peptides act on the parathyroid hormone 1 receptor in bone and kidney. Parathyroid hormone 1 receptor (PTH1R) is a class B G protein-coupled receptor (GPCR) that binds parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHrP). A single receptor for both ligands was cloned in 1991. PTH1R signaling controls calcium and phosphate balance, and a 1996 mouse study linked PTHrP signaling through the receptor to Indian hedgehog-regulated bone growth. Most products here are peptides, such as teriparatide acetate hydrate and Human PTHrP-(1-36). pTH (39-84) (human) is a C-terminal fragment of the hormone. CH5447240 is listed as a small-molecule agonist of the same receptor.
Synonyms: Teriparatide acetate
Human parathyroid hormone (hPTH) peptide fragment; contains the 34 N-terminal residues of hPTH. Agonist at parathyroid 1 (PTH1) and parathyroid 2 (PTH2) receptors.
PTH1R agonist 2 is a selective agonist of the parathyroid hormone 1 receptor (PTH1R). This compound demonstrates significant biological activity in promoting osteoblastic activity and calcium homeostasis, making it valuable for studies related to hypoparathyroidism and osteoporosis. Its potential applications span the investigation of bone metabolism and therapeutic strategies for metabolic bone diseases.
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Synonyms: Human parathyroid hormone-(1-34) acetate hydrate; hPTH (1-34) acetate hydrate
Teriparatide acetate hydrate is a parathyroid hormone (PTH) receptor agonist, specifically acting on the PTH1 receptor. This compound exhibits key biological activity by stimulating bone formation and enhancing calcium absorption, making it crucial for osteoporosis research. Its application extends to studying osteoporosis and related bone metabolism disorders, facilitating the development of therapeutic strategies for bone health.
PTH1R Agonist 1 is a specialized agonist of the parathyroid hormone 1 receptor (PTH1R). This compound exhibits key biological activity by stimulating PTH1R signaling pathways, making it a valuable tool for investigating conditions related to hypoparathyroidism and osteoporosis. Its relevance in research encompasses the exploration of therapeutic strategies targeting bone metabolism and calcium homeostasis.
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CH5447240 is a potent agonist of parathyroid hormone receptor 1 (PTHR1), demonstrating an EC50 of 12 μM in human PTHR1 inhibition. It shows favorable metabolic stability in human liver microsomes and effectively elevates serum calcium levels in rodent models. This compound is valuable for research investigating hypoparathyroidism and related disorders.
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PTH1R Agonist 4 is a selective agonist of the parathyroid hormone 1 receptor (PTH1R), exhibiting a pEC50 value exceeding 7. This compound is valuable for investigating bone metabolic processes and holds potential applications in the study of bone diseases, including osteoporosis. Its ability to activate PTH1R makes it a significant tool for research in therapeutic strategies targeting bone health.
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