β-lactamase

Cat. No.

A50622

CAS No.

1802366-23-9

Metallo-β-lactamase-IN-13

Metallo-β-lactamase-IN-13 is a potent inhibitor of metallo-β-lactamases, targeting enzymes that confer resistance in Gram-negative bacteria. This compound demonstrates significant antibacterial activity against Pseudomonas aeruginosa, making it an important tool for research into combating antibiotic resistance. Its broad-spectrum activity against various metallo-β-lactamases supports investigations into novel therapeutic strategies for treating resistant bacterial infections.

Cat. No.

A50623

CAS No.

1804934-57-3

Metallo-β-lactamase-IN-15

Metallo-β-lactamase-IN-15 is a potent inhibitor of metallo-β-lactamases (MBLs), targeting enzymes such as NDM-1, IMP-1, and VIM-2 with IC50 values of 0.29 μM, 0.088 μM, and 0.063 μM, respectively. This compound is valuable for research into antibiotic resistance mechanisms and the development of novel therapeutic strategies. It may be utilized in studies aimed at understanding the functional role of MBLs in bacterial pathogens.

Cat. No.

A50624

CAS No.

3035447-45-8

YJ196

YJ196 is a selective inhibitor of New Delhi Metallo-β-lactamase-1 (NDM-1). It effectively interferes with the enzyme's function, thereby restoring the activity of β-lactam antibiotics against NDM-1-producing bacterial strains. This compound is valuable for research in antibiotic resistance and the development of novel therapeutic strategies targeting multidrug-resistant infections.

Cat. No.

A50625

CAS No.

156916-81-3

N-Cbz-D-Cysteine

Synonyms: Cbz-D-Cys

N-Cbz-D-Cysteine is a potent inhibitor of β-lactamase II with a Ki value of 20.1 µM. This compound can be utilized in the study of antibiotic resistance mechanisms and the development of novel β-lactamase inhibitors. N-Cbz-D-Cysteine's biological activity makes it a valuable reagent in research focusing on antimicrobial strategies and enzymatic inhibition.

Cat. No.

A50626

CAS No.

53907-29-2

N-Cbz-L-Cysteine

Synonyms: Cbz-cysteine

N-Cbz-L-Cysteine is a potent inhibitor of β-lactamase II, demonstrating a Ki value of 97 µM. This compound is useful in biochemical research aimed at overcoming antibiotic resistance by targeting β-lactamase enzymes. N-Cbz-L-Cysteine may be employed in studies exploring the inhibition of β-lactamase-mediated antibiotic degradation and enhancing the efficacy of β-lactam antibiotics.

Cat. No.

A50627

CAS No.

2708983-65-5

Xeruborbactam isoboxil

Xeruborbactam isoboxil is a novel beta-lactamase inhibitor that effectively targets and inhibits the activity of various beta-lactamases. Its primary mechanism involves the binding to the active site of these enzymes, preserving the efficacy of beta-lactam antibiotics. This compound is particularly valuable in combating antibiotic resistance and is utilized in research focused on understanding and overcoming beta-lactam resistance in bacterial infections.

Cat. No.

A50628

CAS No.

2842084-52-8

GT-055

Synonyms: LCB18-055

GT-055 is a potent β-lactamase inhibitor that demonstrates broad-spectrum activity against a variety of β-lactamase enzymes. This compound effectively enhances the efficacy of β-lactam antibiotics by preventing their hydrolysis, making it a valuable tool in combating antibiotic resistance. GT-055 is suitable for research applications focused on understanding β-lactamase mechanisms and developing new therapeutic strategies.

Cat. No.

A50629

CAS No.

2757462-75-0

trans-Cephalosporin

Trans-Cephalosporin is a potent NDM-1 inhibitor, exhibiting an IC50 value of 0.13 μM. This compound effectively targets the New Delhi metallo-beta-lactamase-1 enzyme, playing a crucial role in overcoming antibiotic resistance. Trans-Cephalosporin is valuable in research applications focused on developing novel antimicrobial strategies and understanding resistance mechanisms in pathogenic bacteria.

Cat. No.

A50630

CAS No.

2190527-04-7

ZN148

ZN148 is a synthetic metallo-β-lactamase (MBL) inhibitor that functions by chelating zinc, crucial for MBL activity. This compound effectively mitigates MBL-mediated carbapenem resistance, restoring susceptibility to carbapenems in over 98% of diverse clinical Enterobacterales strains. ZN148 is valuable for research in combating MBL-producing pathogenic bacteria and understanding resistance mechanisms in bacterial infections.

Cat. No.

A50632

CAS No.

112243-88-6

epi-D-Captopril

Synonyms: epi-D-SQ 14225

epi-D-Captopril is a stereoisomer of Captopril that serves as an inhibitor of metallo-β-lactamases (MBLs). It demonstrates inhibitory activity with IC50 values against NDM-1, IMP-1, and VIM-2 of 64 μM, 173 μM, and 5.5 μM, respectively. This reagent is useful for research applications focused on understanding and addressing drug-resistant bacterial infections associated with MBLs.

Cat. No.

A50633

CAS No.

1639972-90-9

ANT431

ANT431 is a metallo-β-lactamase inhibitor that enhances the efficacy of beta-lactam antibiotics, particularly Meropenem. This compound is designed for applications in combating antibiotic resistance by restoring the effectiveness of β-lactam antibiotics in bacterial infections, specifically in models involving Escherichia coli. Its potential utility in therapeutic contexts makes it a valuable reagent for microbiological and pharmacological research.

Cat. No.

A50634

CAS No.

76265-39-9

Izumenolide

Izumenolide is a potent β-lactamase inhibitor derived from the strain Micromonospora chalcea subsp. izumensis. It exhibits significant inhibitory activity against certain β-lactamases, with an IC50 value of 0.01 μg/mL specifically for TEM-2 β-lactamase. This compound is valuable for research applications focused on antibiotic resistance and the development of new therapeutic strategies targeting bacterial infections.

Cat. No.

A50637

CAS No.

50743-17-4

3-Cyanochromone

3-Cyanochromone is a dual inhibitor targeting NDM-1 and VIM-2 with KD values of 181 μM and 999 μM, respectively. This compound demonstrates significant potential in antibiotic research, contributing to the study of β-lactamase enzymes and their role in antibiotic resistance. Its unique structural properties make it a valuable tool for exploring therapeutic strategies against resistant bacterial strains.