β-lactamase

Cat. No.

A48449

CAS No.

623564-40-9

BLI-489

BLI-489 is a potent beta-lactamase inhibitor that effectively targets class A, class C (AmpC), and class D beta-lactamase producing pathogens. When used in combination with Piperacillin, BLI-489 enhances antimicrobial activity, providing a therapeutic strategy against infections caused by resistant bacteria. This compound is essential for research aimed at understanding and overcoming beta-lactam resistance mechanisms in clinical pathogens.

Cat. No.

A48606

CAS No.

4695-09-4

Thiomandelic acid

Thiomandelic acid is a potent inhibitor of metallo-β-lactamases, specifically targeting zinc-dependent enzymes. It exhibits broad-spectrum antibacterial activity by effectively preventing the hydrolysis of β-lactam antibiotics. This compound is valuable for research applications focused on antibiotic resistance mechanisms and the development of novel therapeutics against resistant bacterial infections.

Cat. No.

A48640

CAS No.

2170834-56-5

Xeruborbactam bis-acetoxy methyl ester

Xeruborbactam bis-acetoxy methyl ester is a boronic acid derivative that functions as a β-lactamase inhibitor. This compound effectively targets β-lactamase enzymes, providing a mechanism to counteract antibiotic resistance in bacterial strains. It is primarily utilized in research focused on developing novel antibacterial therapies and studying the mechanisms of β-lactamase-mediated resistance.

Cat. No.

A48722

CAS No.

2058069-25-1

Metallo-β-lactamase-IN-16

Metallo-β-lactamase-IN-16 is a potent metallo-β-lactamase inhibitor targeting critical enzymes responsible for antibiotic resistance. This sulfone-containing compound shows significant antibacterial activity by effectively inhibiting NDM-1, IMP-1, VIM-1, and VIM-2, with IC50 values of 0.16 nM, 0.23 nM, 0.31 nM, and 1.0 nM, respectively. It serves as a valuable tool for research in combating bacterial infections and understanding the mechanisms of antibiotic resistance.

Cat. No.

A48724

CAS No.

1501705-61-8

Metallo-β-lactamase-IN-2

Metallo-β-lactamase-IN-2 is a potent inhibitor of metallo-β-lactamases (MBL), exhibiting IC50 values of 0.1 μM for VIM-1, 1.3 μM for NDM-1, and 5.0 μM for IMP-7. This compound plays a significant role in combating antibiotic resistance by targeting critical enzymes that hydrolyze β-lactam antibiotics. Its robust inhibitory profile makes it a valuable tool for research applications focused on bacterial resistance mechanisms and developing new therapeutic strategies.

Cat. No.

A48758

CAS No.

3035446-91-1

YJ182

YJ182 is a selective NDM-1 inhibitor with an IC50 of 0.23 μM. It also demonstrates inhibitory activity against IMP-1, VIM-2, GIM-1, and MMP-2, with IC50 values of 0.25, 0.61, 0.49, and 6.92 μM, respectively. This compound is valuable for research focused on bacterial infections and the development of resistance mechanisms.

Cat. No.

A48829

CAS No.

2872672-18-7

EBL-3183

EBL-3183 is a potent inhibitor of metallo-β-lactamases (MBLs) that targets the NDM-1 enzyme. This indole-2-carboxylate compound exhibits reversible, non-covalent, and competitive inhibition characterized by a pIC50 value of 7.7. EBL-3183 is valuable for research applications focused on combating antibiotic resistance and exploring mechanisms of MBL inhibition.

Cat. No.

A48830

CAS No.

2170834-57-6

Xeruborbactam methoxy acetoxy methy ester

Xeruborbactam methoxy acetoxy methyl ester is a boronic acid derivative specifically designed as a β-lactamase inhibitor. This compound effectively inhibits the enzymatic activity of β-lactamases, which are responsible for antibiotic resistance in various bacterial strains. It is primarily utilized in research applications aimed at understanding β-lactamase mechanisms and developing novel antimicrobial therapies.

Cat. No.

A48833

CAS No.

3034185-71-9

KPC-2-IN-2

KPC-2-IN-2 is a potent inhibitor of Klebsiella pneumoniae carbapenemase (KPC-2), demonstrating a dissociation constant (Ki) of 0.038 μM. This compound effectively enhances the antimicrobial activity of cefotaxime against KPC-2 expressing Escherichia coli. KPC-2-IN-2 serves as a valuable tool in research focused on overcoming antibiotic resistance in Gram-negative bacteria.

Cat. No.

A48917

CAS No.

2163782-59-8

Pralurbactam

Synonyms: FL058

Pralurbactam is a potent β-lactamase inhibitor that enhances the antibacterial efficacy of Imipenem against Mycobacterium abscessus. Its ability to reduce pulmonary bacterial load in neutropenic mice highlights its potential as a significant therapeutic agent. This compound is valuable in research focused on infections caused by Mycobacterium abscessus complex, as well as strains of Escherichia coli and Klebsiella pneumoniae.

Cat. No.

A48918

CAS No.

128294-71-3

Metallo-β-lactamase-IN-3

Metallo-β-lactamase-IN-3 is a potent inhibitor of metallo-β-lactamases (MBLs), specifically targeting VIM-1 and NDM-1 with IC50 values of 0.6 and 1.0 μM, respectively. This compound exhibits selectivity, as it does not inhibit IMP-7. Metallo-β-lactamase-IN-3 is a valuable tool for research in antibiotic resistance, providing insights into MBL inhibition and potential therapeutic strategies against resistant bacterial strains.

Cat. No.

A49013

CAS No.

1383814-68-3

rel-Avibactam sodium

Synonyms: NXL-104 sodium

rel-Avibactam sodium is a potent β-lactamase inhibitor designed to combat bacterial resistance. It demonstrates broad-spectrum antibacterial activity, particularly against Enterobacteriaceae that produce Ambler A and C types of β-lactamases. When used in combination with Cefazidime, rel-Avibactam sodium exhibits significant inhibitory effects and offers enhanced efficiency compared to traditional β-lactamase inhibitors, as indicated by its low IC50 values against TEM-1 and P99 enzymes. This compound is essential for research into antibiotic resistance and the development of novel antibacterial therapies.

Cat. No.

A49146

CAS No.

1610537-25-1

Metallo-β-lactamase-IN-8

Metallo-β-lactamase-IN-8 is a potent reversible and competitive inhibitor of metallo-β-lactamases (MβLs), exhibiting IC50 values of 1.3 μM, 5.7 μM, 9.8 μM, and 9.9 μM against L1, ImiS, IMP-1, and VIM-2 respectively. This compound demonstrates significant antibacterial activity, making it a valuable tool for studying β-lactam resistance mechanisms in bacterial pathogens. Its ability to inhibit a broad spectrum of MβLs highlights its potential for research applications in antimicrobial resistance and drug development.

Cat. No.

A49229

CAS No.

1452458-70-6

FPI-1465

FPI-1465 is a dual inhibitor targeting serine β-lactamases and penicillin-binding proteins (PBPs). This compound effectively inhibits PBP2 with an IC50 value of 1.0 µg/mL, demonstrating significant activity against β-lactamase enzymes CTX-M-15 and OXA-48, with Kd values of 0.011 µM and 5.3 µM, respectively. FPI-1465 is suitable for research applications focused on antibiotic resistance and the modulation of β-lactam antibiotic efficacy.

Cat. No.

A49261

CAS No.

2170834-63-4

Xeruborbactam

Xeruborbactam is a potent boronic acid beta-lactamase inhibitor that targets both serine and metallo beta-lactamases with high efficacy. Demonstrating activity in the nanomolar range, it serves as an ultra-broad-spectrum agent in combating antibiotic resistance. Xeruborbactam is valuable for research applications focused on understanding beta-lactamase activity and developing novel antimicrobial strategies.

Cat. No.

A49303

CAS No.

2752453-58-8

Metallo-β-lactamase-IN-7

Metallo-β-lactamase-IN-7 is a specific inhibitor of VIM-type metallo-β-lactamases, demonstrating potent inhibition with IC50 values of 0.019 μM for VIM-2, 13.64 μM for VIM-1, and 0.38 μM for VIM-5. This compound enhances the antibacterial efficacy of Meropenem against Gram-negative bacterial strains, making it a valuable tool in combating antibiotic resistance in microbial research. Its application is crucial for studies focused on understanding and overcoming metallo-β-lactamase mediated resistance mechanisms.

Cat. No.

A49351

CAS No.

2711044-25-4

Metallo-β-lactamase-IN-4

Metallo-β-lactamase-IN-4 is a potent inhibitor of metallo-β-lactamases (MBLs), effectively targeting VIM-1, NDM-1, and IMP-7 with IC50 values of 0.5 μM, 2.1 μM, and 3.3 μM, respectively. This compound is valuable for research applications focused on antibiotic resistance mechanisms, particularly in the study of β-lactamase-mediated hydrolysis of β-lactam antibiotics. By inhibiting MBLs, it provides insight into potential therapeutic strategies to combat resistant bacterial strains.

Cat. No.

A49388

CAS No.

155641-16-0

SA09-Cu

SA09-Cu is a potent noncompetitive inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1), with an IC50 value of 9.6 nM. This compound effectively oxidizes the Zn(II)-thiolate site of the enzyme, rendering NDM-1 inactive while remaining resistant to reduction by intracellular thiols in bacteria. SA09-Cu demonstrates strong inhibitory activity against various clinical strains of NDM-1-producing carbapenem-resistant Enterobacteriaceae (CRE), thereby enhancing the efficacy of meropenem and potentially delaying the emergence of carbapenem resistance.

Cat. No.

A49399

CAS No.

1452395-68-4

MBL-IN-3

MBL-IN-3 is an inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1), demonstrating an IC50 value of 54±4 μM. This compound effectively reduces the minimum inhibitory concentrations (MICs) of Meropenem against various clinical isolates of E. coli and K. pneumoniae that express NDM-1. MBL-IN-3 serves as a valuable tool in antibiotic sensitizer research, contributing to the study of antimicrobial resistance mechanisms and potential therapeutic strategies.

Cat. No.

A49437

CAS No.

364055-05-0

Zndm19

Zndm19 is a selective inhibitor of New Delhi Metallo-β-lactamase-1 (NDM-1), an enzyme that catalyzes resistance to β-lactam antibiotics in pathogenic bacteria. By targeting NDM-1, Zndm19 facilitates the restoration of antibiotic efficacy against drug-resistant bacterial infections. This compound serves as a valuable tool for researching mechanisms of antibiotic resistance and developing effective therapeutic strategies.

Cat. No.

A49451

CAS No.

1463520-91-3

β-Lactamase-IN-4

β-Lactamase-IN-4 is a potent β-lactamase inhibitor that targets β-lactamase enzymes, effectively enhancing the efficacy of β-lactam antibiotics. This compound is critical for research applications focused on combating bacterial infections caused by β-lactamase-producing microorganisms. Its use may contribute to the development of novel therapeutic strategies against resistant bacterial strains.

Cat. No.

A49514

CAS No.

1439899-44-1

Metallo-β-lactamase-IN-6

Metallo-β-lactamase-IN-6 is a potent inhibitor of VIM-type metallo-β-lactamases, demonstrating IC50 values of 0.56 μM for VIM-2, 29.50 μM for VIM-1, and 5.78 μM for VIM-5. This compound exhibits significant antibacterial synergy with Meropenem against engineered Escherichia coli strains and clinically isolated Pseudomonas aeruginosa strains that produce VIM-2 metallo-β-lactamase. It serves as a valuable research tool for exploring resistance mechanisms in bacterial pathogens and for developing novel therapeutic strategies.

Cat. No.

A49521

CAS No.

1452460-31-9

FPI-1602

FPI-1602 is a β-lactamase inhibitor that enhances the efficacy of β-lactam antibiotics. It exhibits significant antimicrobial activity against pathogens such as Pseudomonas aeruginosa, Escherichia coli, and Enterobacter spp. This compound is valuable for research applications aimed at overcoming antibiotic resistance mediated by β-lactamase enzymes.

Cat. No.

A49531

CAS No.

2232877-85-7

KPC-2-IN-1

KPC-2-IN-1 is a specific inhibitor of KPC-2 enzymes, characterized as a boronic acid derivative with a Ki value of 0.032 μM. It significantly enhances the antibacterial activity of cefotaxime against KPC-2 expressing Escherichia coli. Furthermore, KPC-2-IN-1 demonstrates favorable tolerance in human HEK-293 cells, making it a valuable tool for investigating E. coli resistance mechanisms to β-lactam antibiotics.

Cat. No.

A49566

CAS No.

80570-90-7

NDM-1-IN-6

NDM-1-IN-6 is a selective and competitive inhibitor of New Delhi Metallo-β-lactamase-1 (NDM-1), exhibiting a Ki of 0.72 μM. It demonstrates a synergistic antibacterial effect when combined with the carbapenem antibiotic Meropenem, making it a valuable tool for studying NDM-1-mediated multidrug-resistant bacterial infections. This compound is primarily utilized in research applications aimed at understanding and combating antibiotic resistance.