β-lactamase

Cat. No.

A49577

CAS No.

26631-90-3

Brobactam

Brobactam is a potent synthetic β-lactamase inhibitor designed to combat antibiotic resistance by inhibiting β-lactamase enzymes. It exhibits broad-spectrum antibacterial activity, making it valuable in the study and treatment of β-lactamase-mediated resistance in various bacterial infections. Research applications include the evaluation of combination therapies and the development of novel antibacterial agents.

Cat. No.

A49616

CAS No.

2380240-20-8

KSP-1007

KSP-1007 is a bicyclic boronate compound functioning as a broad-spectrum β-lactamase inhibitor. It effectively targets class A, B, C, and D β-lactamases, including serine-type and metallo-type enzymes such as NDM, VIM, and IMP, in addition to Acinetobacter baumannii OXA-type enzymes. KSP-1007 enhances the antibacterial activity of Meropenem, decreasing its minimum inhibitory concentration (MIC) against carbapenemase-producing Enterobacteriaceae, Acinetobacter baumannii, and Pseudomonas aeruginosa. This reagent is suitable for research on bacterial infections and antibiotic resistance mechanisms.

Cat. No.

A49668

CAS No.

1842399-68-1

Ledaborbactam etzadroxil

Synonyms: VNRX-7145

Ledaborbactam etzadroxil is an orally active inhibitor of Ambler class A, C, and D β-lactamase enzymes. It is designed to provide enhanced protection for β-lactam antibiotics from hydrolysis by these enzymes, thereby improving their efficacy. This compound is particularly relevant in research applications focused on combating antibiotic resistance and expanding the therapeutic options for bacterial infections.

Cat. No.

A49734

CAS No.

1929555-36-1

β-Lactamase-IN-8

β-Lactamase-IN-8 is a potent β-lactamase inhibitor with a broad-spectrum profile, utilizing a cyclic boronate structure to enhance oral bioavailability. It effectively inhibits various β-lactamases, making it a valuable tool for studying antibacterial resistance mechanisms and developing new therapeutic strategies against resistant bacterial strains. Researchers can utilize β-Lactamase-IN-8 for investigating the efficacy of β-lactam antibiotics in microbial infections.

Cat. No.

A49747

CAS No.

2419903-21-0

β-Lactamase-IN-7

β-Lactamase-IN-7 is a potent inhibitor of VIM-type metallo-β-lactamases, exhibiting inhibition constants (Ki) of 1.26 μM and 0.54 μM for VIM-1 and VIM-4, respectively. This compound demonstrates effective inhibition against Klebsiella pneumoniae, making it valuable for studies focused on antibiotic resistance and the development of novel therapeutic strategies against resistant bacterial infections. Its role in characterizing metallo-β-lactamase activity positions it as an important tool in chemical biology research.

Cat. No.

A49784

CAS No.

2410688-60-5

Pilabactam

Synonyms: ANT3310

Pilabactam is a potent covalent inhibitor of serine β-lactamases, exhibiting IC50 values between 1 nM and 175 nM across various serine β-lactamase types. This compound significantly enhances the efficacy of β-lactam antibiotics against challenging pathogens such as Carbapenem-Resistant Enterobacterales (CRE) and Acinetobacter baumannii (CRAB). Pilabactam is valuable in research focused on bacterial infections and antibiotic resistance mechanisms.

Cat. No.

A49794

CAS No.

604811-49-6

NDM-1 inhibitor-4

NDM-1 inhibitor-4 is a potent inhibitor of the New Delhi metallo-beta-lactamase-1 (NDM-1) enzyme, exhibiting a Ki value of 1.7 μM. This compound demonstrates significant antimicrobial activity, making it a valuable tool for research into antibiotic resistance mechanisms. Its application spans the development of therapeutic strategies targeting NDM-1-mediated resistance in bacterial infections.

Cat. No.

A49804

CAS No.

1463521-39-2

β-Lactamase-IN-5

β-Lactamase-IN-5 is a potent β-lactamase inhibitor that serves to enhance the efficacy of β-lactam antibiotics against resistant bacterial strains. Its primary mechanism involves the inhibition of β-lactamase enzymes, which are responsible for antibiotic resistance. This compound is valuable for research applications aimed at understanding and combating bacterial infections, particularly those caused by multidrug-resistant pathogens.

Cat. No.

A49821

CAS No.

2270184-16-0

ANT2681

ANT2681 is a potent inhibitor of New Delhi Metallo-β-lactamase (NDM), exhibiting a Ki of 0.04 μM against NDM-1. It also shows inhibitory activity against other metallo-β-lactamases, including VIM-1 and IMP-1, with Ki values of 0.63 μM and 3.81 μM, respectively. ANT2681 is suitable for research applications focused on combating infections caused by NDM-producing Enterobacteriaceae, especially when used in combination with meropenem.

Cat. No.

A49907

CAS No.

1802363-75-2

Metallo-β-lactamase-IN-9

Metallo-β-lactamase-IN-9 is a pan metallo-beta-lactamase (MBL) inhibitor that demonstrates inhibitory activity with IC50 values of 35 nM for NDM-1, 269 nM for VIM-1, and 369 nM for IMP-1. This compound is essential for studying antibiotic resistance mechanisms and has potential applications in developing novel antibacterial therapies. Its effective inhibition of MBLs makes it a valuable tool for researchers focusing on combating drug-resistant pathogens.

Cat. No.

A50079

CAS No.

2876921-34-3

MBL-IN-5

MBL-IN-5 is a selective metallo-β-lactamase (MBL) inhibitor, targeting clinically significant B1 subfamily MBLs, including NDM-1, VIM-1, and IMP-1, with IC50 values of 0.05 nM, 14 nM, and 21 nM, respectively. This compound significantly enhances the efficacy of carbapenems against MBL-producing bacterial strains. Additionally, MBL-IN-5 effectively reduces bacterial load in a neutropenic murine thigh infection model when used in combination with the antibiotic imipenem, making it a valuable tool for research into antibiotic resistance and MBL-related infections.

Cat. No.

A50114

CAS No.

2209871-79-2

ETX1317

ETX1317 is a potent β-lactamase inhibitor designed to restore the antibacterial efficacy of various β-lactam antibiotics, including third-generation cephalosporins like Cefpodoxime. This reagent is ideal for investigating bacterial resistance mechanisms and enhancing the therapeutic effectiveness of β-lactam therapies in research settings focused on bacterial infections.

Cat. No.

A50174

CAS No.

1463520-70-8

CB-618

CB-618 is a β-lactamase inhibitor that reversibly covalently interacts with Ambler class A, C, and select class D serine β-lactamases. While it exhibits limited antibacterial activity on its own, CB-618 notably enhances the effectiveness of Meropenem against enzyme-producing Enterobacteriaceae. This compound is a valuable tool for research focused on combating drug-resistant bacterial strains.

Cat. No.

A50178

CAS No.

1613045-02-5

NDM-1 inhibitor-5

NDM-1 inhibitor-5 is a potent inhibitor of the New Delhi metallo-beta-lactamase-1 (NDM-1), exhibiting a Ki value of 2.5 μM. This compound demonstrates significant antibacterial synergy with meropenem, making it a valuable tool for studying antibiotic resistance mechanisms and developing novel therapeutic strategies against NDM-1 producing pathogens. Suitable for use in microbiological assays and resistance studies, NDM-1 inhibitor-5 is a critical reagent for researchers focused on combating multidrug-resistant bacterial infections.

Cat. No.

A50181

CAS No.

247115-03-3

LN-1-255 sodium

LN-1-255 sodium is a β-lactamase inhibitor designed to effectively combat resistance in bacteria. It exhibits a broad-spectrum inhibitory effect on type D carbapenemases, demonstrating an IC50 of 3 nM against OXA-48, while also showing strong activity against OXA-23 and OXA-24/40. The compound enhances the efficacy of carbapenem antibiotics through a synergistic mechanism. LN-1-255 sodium is a valuable tool for researching the challenges posed by carbapenem-hydrolyzing class D β-lactamases (CHDLs) in bacterial resistance.

Cat. No.

A50391

CAS No.

1502858-91-4

Relebactam sodium

Synonyms: MK-7655 sodium

Relebactam sodium is a potent and selective β-lactamase inhibitor that functions to inhibit the enzymatic breakdown of β-lactam antibiotics. By binding to a diverse range of β-lactamases, Relebactam sodium enhances the effectiveness of these antibiotics and delays the emergence of bacterial resistance. This compound is particularly valuable in research focusing on combating complex bacterial infections and improving antibiotic therapeutic options.

Cat. No.

A50429

CAS No.

396731-20-7

ent-Avibactam sodium

Synonyms: AVE1330A

Ent-Avibactam sodium is a β-lactamase inhibitor designed to combat a wide range of bacterial infections. It effectively inhibits Ambler A and C type β-lactamases produced by Enterobacteriaceae, enhancing the efficacy of β-lactam antibiotics like Cefazidime. With an IC50 value significantly lower than other commonly used β-lactamase inhibitors, ent-Avibactam sodium demonstrates superior potency against TEM-1 and P99 enzymes, making it a valuable tool for bacterial resistance research and antibiotic development.

Cat. No.

A50448

CAS No.

26151-73-5

NDM-1 inhibitor-7

NDM-1 inhibitor-7 is a potent inhibitor of the New Delhi metallo-beta-lactamase 1 (NDM-1) enzyme, exhibiting an IC50 of 10.284 μM. This compound enhances the permeability of meropenem (MEM) through the cell wall of gram-negative bacteria, thereby reinstating the antibacterial efficacy of MEM against NDM-1-positive Escherichia coli. NDM-1 inhibitor-7 has demonstrated substantial effectiveness in both the Galleria mellonella infection model and the murine peritonitis infection model, making it valuable for research in antibiotic resistance and therapeutic development.

Cat. No.

A50477

CAS No.

1770826-25-9

D-CS319

D-CS319 is a potent inhibitor of metallo-β-lactamases (MBLs), exhibiting IC50 values of 2.0 μM for IMP-1 and 3.0 μM for IMP-78. This compound demonstrates significant antibacterial activity, making it a valuable tool for research aimed at combating drug-resistant bacterial infections. D-CS319 is suitable for studies focusing on the inhibition of MBLs and their role in antibiotic resistance.

Cat. No.

A50603

CAS No.

3044733-61-8

NDM-1-IN-10

NDM-1-IN-10 is a potent irreversible and covalent inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1), demonstrating an IC50 of 36 nM. This compound exhibits synergistic effects with Meropenem against NDM-1-expressing E. coli, with an observed MIC of 0.25 μg/mL for E. coli BL21/pET15b-blaNDM-1. NDM-1-IN-10 serves as a valuable tool for research focused on bacterial infections and mechanisms of antibiotic resistance.

Cat. No.

A50614

CAS No.

2209871-83-8

ETX0282

ETX0282 is a β-lactamase inhibitor that functions as an orally active prodrug, converted in the liver to its active form, ETX1317. This compound demonstrates excellent stability during intestinal absorption and enhances the efficacy of antibiotics, like Cefpodoxime Proxetil, in reducing bacterial load in models of neutropenic infections. ETX0282 is useful for research focused on combating infections caused by drug-resistant Gram-negative bacteria.

Cat. No.

A50615

CAS No.

80072-86-2

CENTA

CENTA is a colorimetric substrate specifically designed for the detection of beta-lactamase activity. Upon hydrolysis by beta-lactamases, CENTA undergoes a color change from light yellow to chrome yellow, facilitating quantification via colorimetric detection at 405 nm. This property makes CENTA an effective tool for studying β-lactamase function and assessing antibiotic resistance mechanisms in microbial research.

Cat. No.

A50617

CAS No.

9073-60-3

β-Lactamase

β-Lactamase is an enzyme produced by various bacteria that hydrolyzes β-lactam antibiotics, thereby contributing to antibiotic resistance. This enzyme plays a critical role in bacterial survival against β-lactam treatments, making it a key target for research in antimicrobial resistance. It is utilized in the study of antibiotic efficacy and the development of β-lactamase inhibitors for overcoming resistance mechanisms in pathogenic bacteria.

Cat. No.

A50620

CAS No.

2066-93-5

Doxazosin impurity 12

Doxazosin impurity 12 is identified as a CTX-M β-lactamase inhibitor, exhibiting a Ki value of 0.7 mM against the CTX-M enzyme. This compound is valuable for research applications aimed at overcoming antibiotic resistance mediated by β-lactamases, particularly in the study of bacterial infections and the development of novel antimicrobial strategies.

Cat. No.

A50621

CAS No.

1802367-43-6

Metallo-β-lactamase-IN-14

Metallo-β-lactamase-IN-14 is a potent inhibitor of metallo-β-lactamases, specifically targeting VIM-1 and VIM-2 enzymes. This compound demonstrates significant antibacterial activity against Gram-negative bacteria, including Pseudomonas aeruginosa. It is a valuable tool for research applications aimed at combating resistance in clinical pathogens.