E3 Ligase Ligands

Cat. No.

A80265

CAS No.

2162120-75-2

VH032-PEG2-NH-BOC

VH032-PEG2-NH-BOC is a Boc-modified VH032 compound that functions as a ligand for E3 ligase von Hippel-Lindau (VHL). This reagent facilitates the recruitment of VHL proteins and can be deprotected under acidic conditions, enabling its direct application in PROTAC molecule synthesis. VH032-PEG2-NH-BOC serves as a crucial intermediate for generating PROTACs utilizing VHL ligands, thereby advancing research in targeted protein degradation and therapeutic applications.

Cat. No.

A80291

CAS No.

2409007-41-4

VH032-O-C2-NH-Boc

VH032-O-C2-NH-Boc is a Boc-modified derivative of VH032, functioning as a ligand for the E3 ubiquitin ligase von Hippel-Lindau (VHL). This compound facilitates the recruitment of VHL proteins and is valuable in the synthesis of PROTAC (Proteolysis Targeting Chimera) molecules. The Boc protective group can be removed under acidic conditions, allowing for efficient integration into PROTAC development and research applications focused on targeted protein degradation.

Cat. No.

A80301

CAS No.

2399455-48-0

Lenalidomide 4'-PEG2-azide

Lenalidomide 4'-PEG2-azide is a Lenalidomide-derived ligand that targets Cereblon, facilitating the recruitment of CRBN protein. This compound can be utilized to create PROTACs by linking it to various proteins, thereby enabling targeted protein degradation and advancing research in drug development and cellular regulation. Its use is relevant in the study of E3 ligase-mediated pathways and therapeutic strategies in oncology and immunology.

Cat. No.

A80375

CAS No.

2564467-16-7

VH 101 phenol-alkylC6-amine dihydrochloride

VH 101 phenol-alkylC6-amine dihydrochloride is a functionalized ligand targeting the von-Hippel-Lindau (VHL) protein, facilitating the development of PROTACs. This compound promotes selective protein degradation by engaging E3 ligases, making it a valuable tool for studying protein turnover and cellular regulation. Its application in chemical biology can aid in understanding the mechanisms of targeted protein degradation and potential therapeutic interventions.

Cat. No.

A80415

CAS No.

2624181-61-7

Pomalidomide 4'-PEG5-azide

Pomalidomide 4'-PEG5-azide is a Pomalidomide-derived ligand specifically targeting the cereblon (CRBN) protein. This compound facilitates the recruitment of CRBN, making it a valuable tool in the development of PROTACs by linking to proteins through a suitable linker. Its application in chemical biology research enhances understanding of protein degradation pathways and E3 ligase modulation.

Cat. No.

A80443

CAS No.

2152672-96-1

E3 ligase Ligand 79

E3 ligase Ligand 79 serves as a ligand for the CRBN E3 ligase, facilitating the development of targeted protein degradation strategies. This compound is crucial for the synthesis of PROTAC CDK2/4 Degrader-1, which allows for selective degradation of protein targets in various biological contexts. Researchers can utilize this ligand to study the mechanisms of E3 ligase-mediated degradation and its potential therapeutic applications.

Cat. No.

A80444

CAS No.

2924858-25-1

PT-179

PT-179 is a selective cereblon ligand that facilitates targeted protein degradation without off-target effects commonly associated with Thalidomide derivatives. It binds specifically to cereblon, forming a ternary complex with proteins fused to zinc finger degrons, thereby promoting their degradation. This compound demonstrates efficient degradation of proteins tagged with SD40 or SD36, achieving DC50 values of 4.5 nM and 14.3 nM for eGFP, respectively. PT-179 is valuable for developing advanced protein degradation systems in cellular and molecular biology research.

Cat. No.

A80447

CAS No.

1158264-69-7

Lenalidomide-5-aminomethyl hydrochloride

Lenalidomide-5-aminomethyl hydrochloride is a derivative of Lenalidomide that acts as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN to target proteins, enabling targeted protein degradation through the formation of PROTACs (proteolysis-targeting chimeras). It is a valuable tool for researchers exploring protein homeostasis and therapeutic applications in cancer and other diseases where modulation of protein levels is critical.

Cat. No.

A80448

CAS No.

2300099-98-1

E3 ligase Ligand 32

E3 Ligase Ligand 32 is a selective ligand for E3 ubiquitin ligase, facilitating the targeted degradation of specific proteins via the PROTAC approach. This compound can be conjugated with a protein ligand through a linker to create innovative PROTACs, such as the SMARCA2/4-degrader-29. E3 Ligase Ligand 32 is valuable for research into protein regulation and degradation pathways, enabling studies in cancer biology and therapeutic development.

Cat. No.

A80449

CAS No.

2304754-51-4

E3 ligase Ligand 63

E3 Ligase Ligand 63 is an E3 ligase ligand that facilitates the synthesis of targeted protein degraders, including CDK2 degrader 2. This compound is instrumental in research applications focused on targeted protein degradation and ubiquitin-proteasome system modulation. Its use enables scientists to explore novel therapeutic strategies by selectively regulating protein levels in various biological contexts.

Cat. No.

A80450

CAS No.

2446913-88-6

CRBN ligand-547

CRBN ligand-547 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the development of Proteolysis Targeting Chimeras (PROTACs). Its specific mechanism of action supports research in targeted protein degradation and the modulation of cellular pathways.

Cat. No.

A80453

CAS No.

1267337-47-2

CRBN ligand-880

CRBN ligand-880 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in the design of PROTACs (proteolysis-targeting chimeras) by linking it to a ligand that binds a specific target protein, enabling targeted protein degradation. Its application in chemical biology research includes elucidating protein function and modulating cellular pathways through controlled degradation mechanisms.

Cat. No.

A80454

CAS No.

2758533-77-4

CRBN ligand-109

CRBN ligand-109 is a selective ligand for the CRBN E3 ubiquitin ligase, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound can effectively promote the ubiquitination and subsequent degradation of target proteins, making it a valuable tool in the study of protein regulation and degradation pathways. Its application is critical in drug discovery, particularly in targeting disease-associated proteins for therapeutic intervention.

Cat. No.

A80457

CAS No.

2093387-36-9

Lenalidomide-Br

Lenalidomide-Br is an analog of the cereblon (CRBN) ligand Lenalidomide, functioning as a ligand for the E3 ubiquitin ligase. This compound effectively recruits the CRBN protein, facilitating targeted protein degradation. Lenalidomide-Br can be utilized to create PROTACs, such as the PROTAC STAT3 degrader SD-36, expanding its application in studies focused on targeted therapy and protein modulation in various biological contexts.

Cat. No.

A80458

CAS No.

2361138-33-0

CCW16

CCW16 is a ligand for RNF4, facilitating the synthesis of targeted protein degraders. It serves as a crucial cofactor in the development of PROTACs, such as CCW 28-3, by enhancing the ubiquitination process that promotes protein degradation. This reagent is essential for research involving protein homeostasis and therapeutic development using protein degradation strategies.

Cat. No.

A80459

CAS No.

92137-90-1

CRBN ligand-881

CRBN ligand-881 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the construction of PROTACs (proteolysis-targeting chimeras) by linking it to a target protein ligand through a suitable linker. CRBN ligand-881 is essential for studies involving targeted protein degradation, making it a valuable tool in drug discovery and development research.

Cat. No.

A80460

CAS No.

3053860-67-3

DCAF1 binder 1

DCAF1 binder 1 is a selective ligand for the CRL4 DCAF1 E3 ligase complex. This compound plays a crucial role in targeted protein degradation (TPD), making it valuable for research applications focused on modulating protein levels and understanding the mechanisms of E3 ligase activity. DCAF1 binder 1 can facilitate investigations into the therapeutic potential of TPD in various disease contexts.

Cat. No.

A80461

CAS No.

2408341-97-7

VH 101, acid

VH 101, acid is a functionalized von-Hippel-Lindau (VHL) protein ligand designed for PROTAC (proteolysis-targeting chimera) research and development. This compound features an E3 ligase ligand along with an alkyl linker equipped with a terminal amine, facilitating conjugation to a target protein ligand. VH 101, acid offers key applications in targeted protein degradation studies, providing insights into therapeutic interventions in various diseases.

Cat. No.

A80462

CAS No.

2438241-40-6

5,6-Difluoro-desamino lenalidomide

5,6-Difluoro-desamino lenalidomide is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein to target proteins. This compound serves as a critical building block in the design of PROTACs (proteolysis-targeting chimeras) that harness the ubiquitin-proteasome system for targeted protein degradation. Its unique properties make it valuable for investigating protein modulation and therapeutic strategies in various biological contexts.

Cat. No.

A80463

CAS No.

1010100-26-1

Lenalidomide-5-Br

Lenalidomide-5-Br is a derivative of Lenalidomide that functions as a ligand for cereblon (CRBN), an E3 ubiquitin ligase. This compound effectively recruits CRBN to target proteins for ubiquitination and degradation, facilitating the development of Proteolysis Targeting Chimeras (PROTACs). Lenalidomide-5-Br is utilized in research focused on targeted protein degradation and therapeutic development for various diseases, including cancers and autoimmune disorders.

Cat. No.

A80465

CAS No.

2207541-30-6

Lenalidomide-I

Lenalidomide-I is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of the CRBN protein, making it a valuable component for the development of PROTACs (Proteolysis Targeting Chimeras). Applications of Lenalidomide-I include the creation of novel PROTACs, such as the PROTAC BET degrader QCA570, which are utilized in targeted protein degradation research.

Cat. No.

A80466

CAS No.

2098799-78-9

(S,R,S)-AHPC-propargyl

Synonyms: VH032-propargyl; VHL ligand 7

(S,R,S)-AHPC-propargyl is a VHL ligand that serves as a crucial component in the development of PROTACs through its role in "click reactions." This compound features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its versatility makes it valuable for drug discovery and chemical biology applications, particularly in the creation of targeted protein degradation strategies.

Cat. No.

A80467

CAS No.

2760850-50-6

E3 ligase Ligand 64

E3 Ligase Ligand 64 functions as a ligand for E3 ligase, enabling its application in targeted protein degradation studies. This compound is instrumental in the synthesis of RP03707, facilitating research in ubiquitin-proteasome pathways and related signaling mechanisms. Its use enhances understanding of E3 ligase activity, making it significant for investigations into disease-related protein dysregulation.

Cat. No.

A80469

CAS No.

1448189-98-7

(S,R,S)-AHPC-Boc

Synonyms: VH032-Boc

(S,R,S)-AHPC-Boc is a ligand that selectively targets the von Hippel-Lindau (VHL) protein, facilitating the recruitment of this E3 ligase. This compound is integral to the development of Proteolysis Targeting Chimeras (PROTACs), enabling the selective degradation of target proteins in cellular systems. Its utility in research applications includes studying protein homeostasis and exploring therapeutic strategies for various diseases.

Cat. No.

A80470

CAS No.

3050687-70-9

CRBN ligand-13

CRBN ligand-13 acts as a ligand for the CRBN-type E3 ubiquitin ligase, facilitating targeted protein degradation via the PROTAC (Proteolysis Targeting Chimeras) approach. It plays a critical role in the development of novel therapeutic strategies for various diseases by enabling the selective elimination of specific proteins within cells. This compound is valuable for researchers focused on protein regulation and targeted drug development.