E3 Ligase Ligands

Cat. No.

A80471

CAS No.

2633633-12-0

PD 4'-oxyacetic acid

PD 4'-oxyacetic acid is a carboxylic acid-functionalized ligand for cereblon, a critical component in the development of PROTAC (Proteolysis Targeting Chimeras) degraders. This compound facilitates targeted protein degradation, making it valuable for research applications focused on protein homeostasis and therapeutic intervention in cancer and other diseases. Its ability to engage with the cereblon E3 ubiquitin ligase complex enhances the potential for novel therapeutic strategies in drug discovery.

Cat. No.

A80472

CAS No.

1416990-08-3

Lenalidomide-OH

Lenalidomide-OH is a potent analog of the cereblon (CRBN) ligand Lenalidomide, designed to selectively engage E3 ubiquitin ligase. This compound facilitates the recruitment of CRBN protein, essential for targeted protein degradation applications. Lenalidomide-OH can be coupled with various ligands via a linker to construct PROTACs, such as the BTK degrader SJF620, making it a valuable tool in studies of protein homeostasis and therapeutic development.

Cat. No.

A80473

CAS No.

2244520-92-9

N-Me-Thalidomide 4-fluoride

N-Me-Thalidomide 4-fluoride is a ligand for E3 ligase, functioning as a tool in targeted protein degradation studies. It plays a critical role in the synthesis of Anti-inflammatory agent 70, which has potential applications in modulating inflammatory pathways. This compound is of significant interest for researchers investigating therapeutic strategies that harness E3 ligase activity in various biological contexts.

Cat. No.

A80474

CAS No.

191732-76-0

5-Aminothalidomide

5-Aminothalidomide is an E3 ligase ligand that plays a crucial role in PROTAC technology. This compound facilitates the synthesis of targeted protein degraders, enabling the development of specific PROTACs such as BRD9 Degrader-7. Its ability to modulate protein levels provides valuable insights into proteostasis and therapeutic intervention in various biological studies.

Cat. No.

A80475

CAS No.

1061604-41-8

3-(4-Hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione

3-(4-Hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione is a ligand for the E3 ligase cereblon (CRBN). This compound enables the targeted recruitment of CRBN, facilitating the degradation of specific proteins through the formation of proteolysis-targeting chimeras (PROTACs). It is a valuable tool for studying protein homeostasis and exploring therapeutic strategies in various diseases, including cancer.

Cat. No.

A80476

CAS No.

2736511-32-1

CRBN ligand-397

CRBN ligand-397 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be connected to a target protein ligand through a linker to create a PROTAC, enabling targeted protein degradation. Its utility in research includes the development of innovative therapeutic strategies that exploit the ubiquitin-proteasome system.

Cat. No.

A80477

CAS No.

1997302-16-5

(S,R,S)-AHPC-Me-NHBoc

(S,R,S)-AHPC-Me-NHBoc is a selective ligand for the E3 ubiquitin ligase von Hippel-Lindau (VHL), facilitating the recruitment of the VHL protein to target substrates. This compound can be conjugated with target protein ligands through a linker to create an effective PROTAC (Proteolysis Targeting Chimera). Its unique properties make it a valuable tool in the study of targeted protein degradation and related biological pathways.

Cat. No.

A80478

CAS No.

2409005-96-3

5-Br-6-F-Desamino lenalidomide

5-Br-6-F-Desamino lenalidomide is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand using a linker, enabling the formation of a PROTAC (proteolysis-targeting chimeras). Its application in targeted protein degradation research offers significant potential for therapeutic intervention in various diseases.

Cat. No.

A80479

CAS No.

2098346-67-7

DCAF15 ligand-1

DCAF15 ligand-1 is a selective ligand for the E3 ubiquitin ligase DCAF15, facilitating its role in substrate recognition and ubiquitination processes. This compound is pivotal in biochemical studies aimed at understanding the mechanistic pathways involving DCAF15-mediated protein degradation. Additionally, DCAF15 ligand-1 can be utilized in the synthesis of associated compounds, such as IBG1, enhancing its relevance in research applications focused on targeted protein modulation.

Cat. No.

A80480

CAS No.

2375196-30-6

KB02-COOH

KB02-COOH is a chemical compound that serves as a ligand for E3 ligase, playing a crucial role in the ubiquitin-proteasome system. This fragment is essential for the synthesis of proteolysis-targeting chimeras (PROTACs), including variants such as KB02-JQ1 and KB02-SLF. Researchers can utilize KB02-COOH in studies focused on targeted protein degradation and the modulation of protein activity within cellular pathways.

Cat. No.

A80481

CAS No.

2171780-01-9

Desamino lenalidomide-6-COOH

Desamino lenalidomide-6-COOH is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand through a linker, enabling the development of a PROTAC (Proteolysis Targeting Chimeras). Desamino lenalidomide-6-COOH is essential for research in targeted protein degradation and has potential applications in drug discovery and therapeutic interventions.

Cat. No.

A80482

CAS No.

2248702-12-5

Desamino lenalidomide-CH2NH2 hydrochloride

Desamino lenalidomide-CH2NH2 hydrochloride functions as a ligand for the E3 ubiquitin ligase protein cereblon (CRBN). This compound is instrumental in the targeted recruitment of cereblon, facilitating the development of protein-targeted degradation strategies. It can be conjugated with a target protein ligand through a suitable linker to create a proteolysis-targeting chimera (PROTAC), thereby advancing research in protein degradation and targeted therapies.

Cat. No.

A80483

CAS No.

2654830-24-5

CRBN ligand-734

CRBN ligand-734 is a potent ligand for the E3 ubiquitin ligase, cereblon (CRBN). This compound facilitates the recruitment of CRBN, enabling targeted protein degradation through the formation of PROTAC (proteolysis-targeting chimeras) by linking it with a target protein ligand via a suitable linker. Its utility is significant in studies focusing on targeted therapy and protein regulation mechanisms in various biological contexts.

Cat. No.

A80484

CAS No.

14149-34-9

E3 ligase Ligand PG

E3 ligase Ligand PG is a selective ligand targeting the CRBN E3 ubiquitin ligase, exhibiting strong binding affinity with an IC50 of 2.191 μM. This compound is suitable for applications involving the recruitment of the CRBN protein, facilitating the development of proteolysis-targeting chimeras (PROTACs). E3 ligase Ligand PG can be utilized in conjunction with BMS-202 to form PROTAC PD-L1 degrader-1, enabling targeted degradation of specific proteins for therapeutic research purposes.

Cat. No.

A80485

CAS No.

2504950-56-3

(S,R,S)-AHPC-Me dihydrochloride

Synonyms: VHL ligand 2 dihydrochloride; E3 ligase Ligand 1 dihydrochloride

(S,R,S)-AHPC-Me dihydrochloride targets the von Hippel-Lindau (VHL) protein as a ligand for E3 ligase recruitment. This compound serves as a critical precursor for the synthesis of ARV-771, a PROTAC degrader that utilizes the VHL E3 ligase to facilitate the degradation of BET proteins. It has demonstrated potent activity in degrading BET proteins in castration-resistant prostate cancer (CRPC) cells, with a DC50 of less than 1 nM, highlighting its potential for therapeutic applications in cancer research.

Cat. No.

A80487

CAS No.

2468780-76-7

Desamino lenalidomide-5-F

Desamino lenalidomide-5-F is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), essential for directing protein degradation via the ubiquitin-proteasome system. This compound facilitates the recruitment of cereblon and can be utilized to create PROTACs by conjugating it to target protein ligands through a linker. Desamino lenalidomide-5-F is instrumental in studies focusing on targeted protein degradation and the exploration of novel therapeutic strategies in various diseases.

Cat. No.

A80489

CAS No.

1448189-90-9

CRBN ligand-798

CRBN ligand-798 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. It can be conjugated to a target protein ligand via a linker to create a proteolysis-targeting chimera (PROTAC). This compound is valuable for research applications focused on targeted protein degradation and the modulation of cellular pathways involving CRBN.

Cat. No.

A80490

CAS No.

1547162-41-3

Pomalidomide-5-OH

Synonyms: 5-Hydroxy pomalidomide; CC-17368

Pomalidomide-5-OH (5-hydroxy pomalidomide) serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN protein. This compound can be utilized in the synthesis of PROTACs by linking it to other ligands, enabling targeted protein degradation. Its applications in chemical biology and drug discovery make it an essential tool for researchers investigating proteostasis and therapeutic strategies.

Cat. No.

A80491

CAS No.

2641512-77-6

CRBN ligand-394

CRBN ligand-394 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound is instrumental in the development of PROTACs by enabling the conjugation of target protein ligands through a linker. Its utility extends to studies in targeted protein degradation and therapeutic applications.

Cat. No.

A80492

CAS No.

2010986-87-3

VHL Ligand 14

VHL Ligand 14 is a specific ligand for the von Hippel-Lindau (VHL) protein, playing a crucial role in the development of PROTACs that target estrogen receptor α (ERα) for degradation. With a binding affinity of 196 nM, it facilitates the targeted ubiquitination and subsequent proteasomal degradation of ERα. This compound is primarily utilized in research applications focused on cancer biology and targeted protein degradation strategies.

Cat. No.

A80493

CAS No.

2222120-31-0

Lenalidomide 5'-piperazine hydrochloride

Lenalidomide 5'-piperazine hydrochloride is a ligand for the E3 ubiquitin ligase Cereblon (CRBN). It facilitates the recruitment of CRBN to target proteins, enabling the development of proteolysis-targeting chimera (PROTAC) molecules for targeted protein degradation. This compound is particularly useful in research focused on modulating protein levels in cellular pathways, contributing to the study of various diseases and therapeutic interventions.

Cat. No.

A80496

CAS No.

2468780-87-0

Lenalidomide-6-F

Lenalidomide-6-F is a modified derivative of Lenalidomide that functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound effectively recruits CRBN, facilitating the targeted degradation of specific proteins via the PROTAC (proteolysis-targeting chimera) mechanism. Lenalidomide-6-F is valuable for research applications focused on the modulation of cellular protein levels and the development of novel therapeutic strategies in cancer and other diseases.

Cat. No.

A80497

CAS No.

2377643-33-7

2-Methoxyphenyl dihydrouracil

2-Methoxyphenyl dihydrouracil serves as a ligand for the cereblon (CRBN) protein, enhancing its interaction in targeted protein degradation assays. This compound is valuable for the development of PROTACs (Proteolysis Targeting Chimeras), facilitating studies in targeted therapy and protein regulation. Its applications extend to research focused on modulating protein levels and understanding ubiquitin-proteasome system mechanisms.

Cat. No.

A80498

CAS No.

2377644-59-0

Hydrouracil-3-Ph-COOH

Hydrouracil-3-Ph-COOH is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in biochemical applications. This compound is designed to be employed in the development of proteolysis-targeting chimeras (PROTACs) by linking to target protein ligands through a suitable linker, making it valuable in targeted protein degradation research. Its utility in creating complex biologics underscores its significance in advancing studies of protein modulation and therapeutic strategies.

Cat. No.

A80499

CAS No.

1547162-46-8

CC-17369

Synonyms: 7-Hydroxy pomalidomide; Pomalidomide metabolite M16

CC-17369 (7-Hydroxy pomalidomide) serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound, a metabolite of Pomalidomide, selectively recruits CRBN, making it a valuable tool in targeted protein degradation studies. CC-17369 can be conjugated to other ligands via a linker to create PROTACs, facilitating research into novel therapeutic strategies for diseases involving protein dysregulation.