E3 Ligase Ligands

Cat. No.

A32898

CAS No.

2230956-57-5

Thalidomide-5-PEG2-Cl

Thalidomide-5-PEG2-Cl is a Thalidomide-derived ligand specifically targeting cereblon (CRBN), facilitating the recruitment of this E3 ligase. It is instrumental in the design and synthesis of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation studies. This reagent is valuable in elucidating CRBN-mediated pathways and exploring therapeutic avenues in cancer and other diseases.

Cat. No.

A32918

CAS No.

2761398-05-2

Thalidomide-5-O-C6-NH2 hydrochloride

Thalidomide-5-O-C6-NH2 hydrochloride is a Thalidomide-derived ligand targeting the E3 ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN, enabling the development of proteolysis-targeting chimeras (PROTACs) by linking it to other proteins. Key applications include targeted degradation studies and biological research involving ubiquitin-proteasome pathways.

Cat. No.

A32947

CAS No.

2758432-02-7

Thalidomide 4'-ether-PEG1-azide

Thalidomide 4'-ether-PEG1-azide is a Thalidomide-derived ligand that specifically targets cereblon (CRBN), facilitating its recruitment for protein degradation. This compound is utilized in the development of proteolysis-targeting chimeras (PROTACs) to enhance targeted protein removal in cellular systems. Its unique structure promotes effective binding and functional interactions in E3 ligase-mediated pathways, supporting studies in protein regulation and therapeutic discovery.

Cat. No.

A32997

CAS No.

2377032-39-6

Thalidomide-NH-CH2-COOH TFA

Thalidomide-NH-CH2-COOH TFA is a thalidomide-derived ligand targeting the E3 ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN, making it a valuable tool in the design of PROTACs for targeted protein degradation research. Its application in the development of bifunctional molecules allows for enhanced modulation of protein levels and contributes significantly to the study of protein homeostasis and therapeutic strategies.

Cat. No.

A33139

CAS No.

2564466-93-7

Thalidomide 4'-oxyacetamide-C1-PEG3-C3-amine hydrochloride

Thalidomide 4'-oxyacetamide-C1-PEG3-C3-amine hydrochloride acts as a functionalized cereblon ligand, primarily utilized in PROTAC (proteolysis-targeting chimeras) research and development. It features a terminal amine, enabling easy conjugation to target protein ligands, thereby facilitating targeted degradation of specific proteins in cellular assays. This compound supports investigations into targeted protein degradation mechanisms and contributes to the advancement of therapeutic strategies in various disease models.

Cat. No.

A42505

CAS No.

3031995-12-4

E3 ligase Ligand 36

E3 Ligase Ligand 36 is a potent E3 ligase ligand that serves as a key substrate for the synthesis of proteolysis-targeting chimeras (PROTACs). It facilitates targeted protein degradation and has been utilized in the development of PROTAC BRM/BRG1 degrader-1. This compound provides valuable tools for research in protein regulation and therapeutic applications in various diseases.

Cat. No.

A43950

CAS No.

382608-09-5

(Rac)-Spirotetramat-enol

(Rac)-Spirotetramat-enol serves as a ligand for E3 ligases, demonstrating significant potential in targeted protein degradation research. Primarily involved in the modulation of acetyl-CoA carboxylase, this compound facilitates the synthesis of PROTAC ADC degraders. Its application in the development of innovative therapeutic strategies underscores its importance in chemical biology and drug discovery.

Cat. No.

A51612

CAS No.

3066896-28-1

Nef ligand-2

Nef ligand-2 is a specific ligand for the Nef protein, functioning primarily as a binder that targets E3 ligases. It plays a crucial role in modulating protein interactions and degradation pathways, offering valuable insights into Nef-related signaling mechanisms. This compound is particularly relevant in research applications focused on HIV pathogenesis and the exploration of therapeutic strategies targeting E3 ligase activity.

Cat. No.

A79955

CAS No.

2624336-86-1

Lenalidomide 4'-PEG1-amine dihydrochloride

Lenalidomide 4'-PEG1-amine dihydrochloride serves as a ligand for E3 ligase, specifically targeting the Cereblon (CRBN) protein. This compound facilitates the recruitment of CRBN, enabling the development of proteolysis-targeting chimeras (PROTACs). Researchers can utilize this reagent to explore targeted protein degradation pathways and investigate potential therapeutic applications in various cancers and other diseases.

Cat. No.

A79968

CAS No.

2624336-88-3

Lenalidomide 4'-PEG2-amine dihydrochloride

Lenalidomide 4'-PEG2-amine dihydrochloride is a Cereblon ligand that targets the CRBN protein, playing a crucial role in E3 ligase recruitment. This compound facilitates the development of PROTACs by linking to various target proteins through a suitable linker. It is valuable for research focused on regulated protein degradation pathways and the study of cellular processes influenced by E3 ligase activity.

Cat. No.

A79969

CAS No.

2876198-36-4

(S,R,S)-AHPC-C2-PEG3-BCN

(S,R,S)-AHPC-C2-PEG3-BCN is a ligand targeting E3 ligases, specifically the von Hippel-Lindau (VHL) E3 ligase. It plays a vital role in the synthesis of PROTACs (proteolysis-targeting chimeras), which mediate targeted degradation of proteins within cells. This compound is intended for research applications in protein degradation and cellular regulation studies.

Cat. No.

A79977

CAS No.

2624336-87-2

Lenalidomide 4'-PEG3-amine dihydrochloride

Lenalidomide 4'-PEG3-amine dihydrochloride is a selective ligand for the E3 ubiquitin ligase Cereblon (CRBN). This compound facilitates the recruitment of CRBN, enabling targeted protein degradation through the PROTAC (Proteolysis Targeting Chimeras) mechanism. Its application includes the development of innovative therapeutic strategies for various diseases by harnessing the ubiquitin-proteasome system for regulated protein turnover.

Cat. No.

A79979

CAS No.

3007650-02-1

Pomalidomide-5-C6-NH2 hydrochloride

Pomalidomide-5-C6-NH2 hydrochloride is a cereblon (CRBN) ligand derived from Pomalidomide. This compound functions by facilitating the recruitment of CRBN proteins, making it an essential tool for the development of PROTAC (Proteolysis Targeting Chimeras) constructs. Its ability to form linkages with target proteins through a linker enhances its utility in targeted protein degradation research, paving the way for innovative therapeutic strategies in various diseases.

Cat. No.

A79991

CAS No.

2375555-72-7

Pomalidomide 4'-alkylC6-azide

Pomalidomide 4'-alkylC6-azide is a cereblon (CRBN) ligand that facilitates selective protein targeting via the recruitment of the CRBN protein. It serves as a key component in the development of PROTACs (Proteolysis Targeting Chimeras), enabling targeted degradation of specific proteins. This reagent is essential for research in targeted protein degradation and the modulation of cellular pathways critical for disease mechanisms.

Cat. No.

A80032

CAS No.

2225940-50-9

Pomalidomide-C6-COOH

Pomalidomide-C6-COOH is a cereblon (CRBN) ligand derived from pomalidomide, designed for the specific recruitment of CRBN proteins. This compound serves as a vital building block for the development of PROTACs by enabling the conjugation of CRBN with various proteins via a linker. Its utility in targeted protein degradation makes it a valuable reagent for research applications in cellular signaling and therapeutic interventions.

Cat. No.

A80094

CAS No.

2863635-03-2

Pomalidomide-5-C8-NH2 hydrochloride

Pomalidomide-5-C8-NH2 hydrochloride is a CRBN ligand derived from Pomalidomide. This compound facilitates the recruitment of the cereblon (CRBN) protein, enabling the design of targeted protein degradation strategies. It can be conjugated with a suitable linker to create PROTACs, which are valuable tools in therapeutic applications for modulating protein levels in various biological contexts.

Cat. No.

A80151

CAS No.

2306389-02-4

VH032-C6-NH-Boc

VH032-C6-NH-Boc is a Boc-modified ligand that targets the von Hippel-Lindau (VHL) E3 ligase, facilitating the recruitment of VHL proteins. Under acidic conditions, it readily deprotection occurs, allowing its direct utilization in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound serves as a crucial intermediate in developing PROTACs utilizing VHL ligands, thereby advancing research in targeted protein degradation.

Cat. No.

A80165

CAS No.

2349429-71-4

(S,R,S)-AHPC-CO-C9-NH2

(S,R,S)-AHPC-CO-C9-NH2 is a Von Hippel-Lindau (VHL) ligand that serves as a crucial building block for the synthesis of E3 ligase ligands utilized in the development of PROTACs (Proteolysis Targeting Chimeras). This compound enhances the understanding of protein degradation pathways and enables targeted protein modulation, making it a valuable tool for researchers investigating targeted therapies in cancer and other diseases.

Cat. No.

A80173

CAS No.

2648285-39-4

Pomalidomide-C11-NH2

Pomalidomide-C11-NH2 is a Pomalidomide derivative that functions as a ligand for the E3 ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN protein, enabling targeted protein degradation applications through PROTAC technology. Its utility in the development of targeted therapeutics offers significant potential for advancing cancer research and treatment strategies.

Cat. No.

A80179

CAS No.

2925306-39-2

Pomalidomide-5-C5-NH2 hydrochloride

Pomalidomide-5-C5-NH2 hydrochloride is a cereblon (CRBN) ligand derived from Pomalidomide, designed to facilitate the recruitment of the CRBN protein. This compound serves as a crucial component for the development of PROTACs that promote targeted protein degradation. Its unique structural modifications enhance its ability to engage with CRBN, enabling innovative research into therapeutic applications in cancer and other diseases.

Cat. No.

A80201

CAS No.

2361119-87-9

VH032-C2-NH-Boc

VH032-C2-NH-Boc is a Boc-modified ligand targeting the von Hippel-Lindau (VHL) E3 ligase, facilitating the recruitment of VHL proteins. Upon exposure to acidic conditions, it readily removes the protecting group, enabling its application in the direct synthesis of PROTAC molecules. This compound serves as an essential intermediate in developing PROTACs that utilize VHL ligands, offering valuable utility in targeted protein degradation research.

Cat. No.

A80218

CAS No.

2827750-25-2

VH032-C3-Boc

VH032-C3-Boc is a Boc-modified derivative of VH032, functioning as a ligand for the E3 ligase von Hippel-Lindau (VHL). Under acidic conditions, VH032-C3-Boc enables the removal of the protective group, facilitating direct utilization in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound serves as an essential intermediate for developing VHL-based PROTACs, contributing to advancements in targeted protein degradation research.

Cat. No.

A80225

CAS No.

2752755-32-9

β-Naphthoflavone-CH2-OH

Synonyms: β-NF-CH2-OH

β-Naphthoflavone-CH2-OH is a selective ligand for the arylhydrocarbon receptor (AhR) E3 ligase. This compound serves as a critical component in the design of targeted protein degradation strategies, such as PROTACs and SNIPERs, by linking to specific protein ligands to facilitate the recruitment of the AhR E3 ligase complex. Its ability to induce ubiquitination-mediated degradation of oncoproteins makes it a valuable tool in cancer research and drug discovery.

Cat. No.

A80231

CAS No.

2763910-08-1

VH 032 amide-PEG6-amine hydrochloride

Synonyms: (S,R,S)-AHPC-PEG6-NH2 hydrochloride

VH 032 amide-PEG6-amine hydrochloride is a functionalized ligand for the von Hippel-Lindau (VHL) E3 ligase, specifically designed for PROTAC (Proteolysis Targeting Chimera) development. This compound features an E3 ligase ligand conjugated to a PEG6 moiety, facilitating the incorporation of terminal amines for coupling with target protein ligands. VH 032 amide-PEG6-amine hydrochloride is essential for advancing research in targeted protein degradation and drug development strategies.

Cat. No.

A80246

CAS No.

2412055-00-4

VH032-C4-NH-Boc

VH032-C4-NH-Boc is a Boc-modified variant of the VH032 compound that serves as a ligand for the von Hippel-Lindau (VHL) protein, facilitating the recruitment of VHL in E3 ligase applications. Upon exposure to acidic conditions, the Boc protecting group is removed, enabling its use in the synthesis of PROTAC molecules. This compound is a critical intermediate for developing PROTAC strategies that leverage VHL ligands for targeted protein degradation research.