E3 Ligase Ligands: Cereblon (CRBN) & VHL

Cat. No.: A31283

CAS No.: 2305936-77-8

Thalidomide-NH-C9-NH2 hydrochloride

Thalidomide-NH-C9-NH2 hydrochloride serves as a ligand for the E3 ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN, enabling targeted protein degradation. It can be conjugated to other ligands through a linker to create proteolysis-targeting chimeras (PROTACs), making it a valuable tool for research in the fields of targeted therapy and protein homeostasis.

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Cat. No.: A31319

CAS No.: 40313-92-6

Thalidomide-5-methyl

Thalidomide-5-methyl functions as an E3 ligase ligand, specifically targeting cereblon (CRBN). This compound facilitates the recruitment of CRBN protein, enabling the development of PROTAC (proteolysis-targeting chimeras) for targeted protein degradation strategies. Thalidomide-5-methyl is a valuable tool in chemical biology and drug discovery research, particularly for studies related to targeted therapies and the modulation of protein stability.

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$50.00

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$125.00

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Cat. No.: A31386

CAS No.: 2694727-89-2

Thalidomide-5-O-C2-NH2 hydrochloride

Thalidomide-5-O-C2-NH2 hydrochloride is a ligand that targets cereblon, an E3 ubiquitin ligase, facilitating the recruitment of CRBN protein. This compound serves as an essential component in the development of PROTACs (proteolysis-targeting chimeras), enabling selective degradation of target proteins. Its unique mechanism allows researchers to explore the therapeutic potential of targeted protein degradation in various biological contexts, including cancer and other diseases.

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Cat. No.: A31468

CAS No.: 2154342-17-1

Thalidomide-4-NH-PEG1-NH-Boc

Thalidomide-4-NH-PEG1-NH-Boc is a Boc-modified derivative of Thalidomide that serves as a ligand for the E3 ubiquitin ligase, Cereblon (CRBN). This compound is integral in PROTAC (proteolysis-targeting chimera) synthesis, allowing for efficient recruitment of CRBN to target proteins for degradation. The Boc protecting group can be removed under acidic conditions, facilitating further chemical modifications required in PROTAC development. Thalidomide-4-NH-PEG1-NH-Boc is an essential intermediate for researchers exploring targeted protein degradation and related therapeutic strategies.

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Cat. No.: A31666

CAS No.: 2357110-58-6

Thalidomide-5-NH-PEG2-NH2 hydrochloride

Thalidomide-5-NH-PEG2-NH2 hydrochloride serves as a ligand for E3 ligase, specifically targeting cereblon (CRBN) proteins. This compound facilitates the formation of PROTAC molecules by linking to a target protein, thereby promoting targeted protein degradation. Its applications extend to the study of protein modulation and degradation pathways in various cellular contexts, enhancing research in drug development and therapeutic strategies.

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Thalidomide-5-propargyne-NH2 hydrochloride

Cat. No.: A31686

CAS No.: 2490402-62-3

Thalidomide-5-propargyne-NH2 hydrochloride

Thalidomide-5-propargyne-NH2 hydrochloride is a thalidomide-derived ligand targeting the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN for targeted protein degradation applications, making it instrumental in the development of PROTACs (proteolysis-targeting chimeras). This compound is valuable in cancer research and therapeutic studies focusing on protein regulation and degradation pathways.

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Cat. No.: A31742

CAS No.: 2983036-20-8

Thalidomide-PEG3-NH2 hydrochloride

Thalidomide-PEG3-NH2 hydrochloride acts as a ligand for E3 ligase, specifically targeting the cereblon (CRBN) protein. This compound facilitates the recruitment of CRBN in protein degradation processes. It serves as a valuable tool for the development of Proteolysis Targeting Chimeras (PROTACs), enabling targeted protein degradation research in various biological studies.

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Cat. No.: A31760

CAS No.: 2093386-36-6

Thalidomide-NH-(CH2)3-NH-Boc

Thalidomide-NH-(CH2)3-NH-Boc is a Boc-modified thalidomide that serves as a ligand for cereblon (CRBN), facilitating the recruitment of CRBN protein within cellular systems. The Boc protecting group can be removed under acidic conditions, enabling its use in the synthesis of PROTAC (proteolysis-targeting chimeras) molecules. This compound plays a crucial role as an intermediate for synthesizing CRBN-based designed PROTACs, particularly those targeting 11β-substituted estradiol, making it valuable for research in targeted protein degradation and therapeutic development.

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Cat. No.: A31872

CAS No.: 2140807-19-6

Thalidomide-4-NH-PEG1-COO(t-Bu)

Thalidomide-4-NH-PEG1-COO(t-Bu) functions as a ligand for E3 ligase, specifically targeting the Cereblon (CRBN) protein. This compound features a t-Bu protecting group, which can be cleaved under acidic conditions, enabling the synthesis of proteolysis-targeting chimeras (PROTACs). It serves as a crucial intermediate in the development of CRBN-based PROTAC molecules, facilitating targeted protein degradation for research applications in cancer and other diseases.

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Cat. No.: A32022

CAS No.: 1957235-57-2

Thalidomide-NH-(CH2)2-NH-Boc

Thalidomide-NH-(CH2)2-NH-Boc is a Boc-modified thalidomide derivative functioning as a ligand for the E3 ubiquitin ligase Cereblon (CRBN). This compound facilitates the recruitment of CRBN, making it an essential intermediate in the synthesis of PROTAC molecules. The Boc protecting group can be removed under acidic conditions, enabling further functionalization and development of targeted protein degradation strategies in chemical biology research.

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Cat. No.: A32089

CAS No.: 2140807-16-3

Thalidomide-4-NH-PEG2-COO(t-Bu)

Thalidomide-4-NH-PEG2-COO(t-Bu) is a thalidomide derivative that serves as a ligand for the E3 ubiquitin ligase Cereblon (CRBN). The t-Bu protecting group can be cleaved under acidic conditions, facilitating its incorporation into PROTAC (Proteolysis Targeting Chimera) synthesis. This compound is essential for research involving targeted protein degradation and the development of CRBN-based PROTAC molecules.

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Cat. No.: A32169

CAS No.: 2761385-94-6

Thalidomide-5-O-C5-NH2 hydrochloride

Thalidomide-5-O-C5-NH2 hydrochloride is a cereblon ligand that targets the E3 ligase CRBN. This compound facilitates the recruitment of CRBN protein, enabling the development of proteolysis-targeting chimeras (PROTACs) by connecting to other proteins through a linker. It serves as a valuable tool for studying protein degradation pathways and exploring therapeutic strategies in various biological contexts.

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Cat. No.: A32226

CAS No.: 2761406-70-4

Thalidomide-5-PEG2-NH2 hydrochloride

Thalidomide-5-PEG2-NH2 hydrochloride is a Thalidomide-derived ligand targeting cereblon (CRBN), an E3 ubiquitin ligase. This compound effectively facilitates the recruitment of CRBN for targeted protein degradation applications. It can be conjugated to other ligands via a linker, making it suitable for the development of PROTACs (proteolysis-targeting chimeras) to study protein function and regulation in various biological contexts.

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Cat. No.: A32264

CAS No.: 458151-34-3

Thalidomide-benzo

Thalidomide-benzo is a Thalidomide-derived ligand specifically designed for the recruitment of the E3 ligase protein cereblon (CRBN). This compound plays a crucial role in the formation of PROTACs (Proteolysis Targeting Chimeras) by enabling targeted degradation of specific proteins. Its application extends to research in cellular models to investigate protein degradation mechanisms and therapeutic strategies in oncology and other diseases.

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Cat. No.: A32307

CAS No.: 2863634-98-2

Thalidomide-5-NH-PEG1-NH2 hydrochloride

Thalidomide-5-NH-PEG1-NH2 hydrochloride is a Thalidomide-derived ligand that targets cereblon, a component of the E3 ubiquitin ligase complex. This compound facilitates the recruitment of CRBN proteins, enabling the development of PROTAC molecules by linking it to target proteins. Thalidomide-5-NH-PEG1-NH2 hydrochloride is valuable for researchers studying targeted protein degradation and E3 ligase modulation in therapeutic applications.

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$50.00

10 mg

$75.00

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Cat. No.: A32447

CAS No.: 1950635-36-5

Thalidomide-4-O-CH2-COO(t-Bu)

Thalidomide-4-O-CH2-COO(t-Bu) is a modified form of Thalidomide that serves as a ligand for the E3 ligase Cereblon (CRBN). It effectively recruits CRBN proteins, facilitating profound biological activity associated with protein degradation pathways. The tert-butyl protecting group can be removed under acidic conditions, enabling its use in the synthesis of PROTAC molecules. This compound is essential for researchers working on CRBN-based PROTAC development.

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Cat. No.: A32451

CAS No.: 2460022-53-9

Thalidomide-NH-C10-NH2 hydrochloride

Thalidomide-NH-C10-NH2 hydrochloride serves as a ligand for the E3 ligase cereblon (CRBN), facilitating targeted protein degradation. This compound enables the recruitment of CRBN to specific proteins through a linker, making it a valuable component in the design of PROTACs. Its application in research includes investigating protein homeostasis and therapeutic strategies for various diseases, including cancer and autoimmune disorders.

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Cat. No.: A32481

CAS No.: 1957235-67-4

Thalidomide-NH-(CH2)2-NH2 TFA

Thalidomide-NH-(CH2)2-NH2 TFA is an alkyl-modified Thalidomide derivative that functions as a ligand for the E3 ubiquitin ligase Cereblon (CRBN). By recruiting CRBN proteins, this compound is a critical intermediate in the development of CRBN-based PROTAC molecules. These PROTACs are engineered to selectively target and degrade the SHP2 protein, making them valuable tools for cancer research and therapeutic applications.

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Cat. No.: A32529

CAS No.: 2357110-84-8

Thalidomide-4-C3-NH2 hydrochloride

Thalidomide-4-C3-NH2 hydrochloride is a Thalidomide-derived ligand that targets cereblon, an E3 ubiquitin ligase. This compound is instrumental in the recruitment of CRBN protein, facilitating the development of PROTACs through linkers connecting the ligand to specific proteins. Thalidomide-4-C3-NH2 hydrochloride is valuable in studies related to targeted protein degradation and therapeutic development in cancer and autoimmune disorders.

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Cat. No.: A32534

CAS No.: 2694727-94-9

Thalidomide-5-O-C3-NH2 hydrochloride

Thalidomide-5-O-C3-NH2 hydrochloride is a novel ligand specifically targeting cereblon (CRBN), functioning as a key component in the recruitment of CRBN protein within protein degradation pathways. This compound is particularly valuable in the development of PROTACs (Proteolysis Targeting Chimeras), enabling the selective degradation of target proteins through the ubiquitin-proteasome system. It holds significant potential for applications in cancer research and therapeutic development by modulating protein activity and turnover.

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Cat. No.: A32543

CAS No.: 2412056-28-9

Thalidomide-5-NH-CH2-COO(t-Bu)

Thalidomide-5-NH-CH2-COO(t-Bu) serves as a ligand for the E3 ubiquitin ligase Cereblon (CRBN). This derivative of Thalidomide features a t-Bu protecting group, which can be removed under acidic conditions, facilitating the development of proteolysis-targeting chimeras (PROTACs). Thalidomide-5-NH-CH2-COO(t-Bu) is crucial for synthesizing CRBN-based PROTACs, enabling targeted protein degradation for various biological research applications.

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Cat. No.: A32768

CAS No.: 2682112-10-1

Thalidomide-5-O-CH2-COO(t-Bu)

Thalidomide-5-O-CH2-COO(t-Bu) is a thalidomide derivative that functions as a ligand for cereblon (CRBN), facilitating the recruitment of the CRBN protein. The tert-butyl protecting group can be cleaved under acidic conditions, enabling its use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound serves as a critical intermediate in the development of CRBN-based PROTAC molecules for targeted protein degradation research.

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Cat. No.: A32792

CAS No.: 2863635-01-0

Thalidomide-5-NH-PEG3-NH2 hydrochloride

Thalidomide-5-NH-PEG3-NH2 hydrochloride is an E3 ligase ligand derived from Thalidomide that selectively engages cereblon (CRBN) proteins. This compound facilitates the synthesis of PROTAC (proteolysis-targeting chimeras) by serving as a connector for target proteins, thereby enabling targeted degradation through the ubiquitin-proteasome pathway. Its applications extend to various areas of biochemical research, particularly in studying protein homeostasis and therapeutic degradation strategies.

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Cat. No.: A32818

CAS No.: 2648939-40-4

Thalidomide-5,6-Cl

Thalidomide-5,6-Cl is a thalidomide-derived compound that functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN, making it a valuable tool for the development of PROTACs (Proteolysis Targeting Chimeras). Thalidomide-5,6-Cl is utilized in research applications focused on targeted protein degradation and the modulation of cellular pathways influenced by CRBN activity.

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Cat. No.: A32839

CAS No.: 2357107-60-7

Thalidomide-5-propoxyethanamine

Thalidomide-5-propoxyethanamine is an E3 ligase ligand specifically designed to target cereblon (CRBN). This compound enhances the recruitment of the CRBN protein, playing a crucial role in modulating protein homeostasis and ubiquitin-proteasome pathways. It is useful for research applications involving targeted protein degradation and the study of CRBN-related signaling pathways.

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