E3 Ligase Ligands

Cat. No.

A80501

CAS No.

2520105-60-4

Lenalidomide 5'-piperazine-4-methylpiperidine hydrochloride

Lenalidomide 5'-piperazine-4-methylpiperidine hydrochloride is an E3 ligase ligand designed for PROTAC (proteolysis-targeting chimera) development. This compound serves as a protein degrader, featuring a terminal piperidine that facilitates further chemical modifications. Its unique structure allows for enhanced interaction with target proteins, making it a valuable tool for studying targeted protein degradation in various research applications.

Cat. No.

A80502

CAS No.

2154343-28-7

CRBN ligand-660

CRBN ligand-660 is a ligand targeting the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker to construct a proteolysis-targeting chimera (PROTAC), making it useful in studies involving targeted protein degradation and cellular protein modulation. Its application in research enables the exploration of new therapeutic strategies by harnessing the ubiquitin-proteasome system.

Cat. No.

A80505

CAS No.

2923549-60-2

3-(4-Bromo-2-chlorophenyl)piperidine-2,6-dione

3-(4-Bromo-2-chlorophenyl)piperidine-2,6-dione is a ligand for the CRBN-type E3 ubiquitin ligase, facilitating targeted protein degradation via the PROTAC (proteolysis-targeting chimeras) approach. This compound can be employed in the development of novel therapeutics that harness the ubiquitin-proteasome system for selective removal of specific proteins. Its applications are significant in disease models where modulation of protein levels is desired for research and therapeutic purposes.

Cat. No.

A80506

CAS No.

2599846-40-7

CRBN ligand-224

CRBN ligand-224 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC), allowing for targeted degradation of proteins in cellular systems. Its application is significant in drug discovery and development, particularly for modulating the activity of specific proteins involved in various diseases.

Cat. No.

A80507

CAS No.

2291363-98-7

Desamino lenalidomide-pinacolborane

Desamino lenalidomide-pinacolborane is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand using a linker to create a PROTAC, enabling targeted protein degradation. Its applications extend to the study of ubiquitin-mediated pathways and drug development strategies aimed at modulating protein levels in various biological contexts.

Cat. No.

A80508

CAS No.

1198787-23-3

Desamino lenalidomide-NO2

Desamino lenalidomide-NO2 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in targeted protein degradation pathways. This compound can be conjugated to target protein ligands through a linker to design and develop PROTAC (proteolysis-targeting chimeras) molecules, enabling precise modulation of protein levels in research applications. Its utility in studying protein degradation mechanisms makes it a valuable tool for drug discovery and cancer research.

Cat. No.

A80509

CAS No.

2962967-27-5

CRBN ligand-11

CRBN ligand-11 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating targeted protein degradation. This compound is instrumental in the synthesis of PROTACs (Proteolysis Targeting Chimeras), which are employed in cellular research to modulate protein levels and investigate the role of specific proteins in various biological processes. Its utility in drug discovery and development marks it as a significant tool for researchers exploring innovative therapeutic approaches.

Cat. No.

A80510

CAS No.

2771069-76-0

GNE7599

GNE7599 is a high-affinity von Hippel-Lindau (VHL) ligand, characterized by a dissociation constant (Kd) of 540 pM. This compound serves as a crucial component for the development of Proteolysis Targeting Chimeras (PROTACs), facilitating the targeted degradation of specific proteins. Its ability to bind with high specificity to VHL makes it an invaluable tool for research in targeted protein modulation and therapeutic applications in cancer and other diseases.

Cat. No.

A80511

CAS No.

2230826-33-0

(R,S,S)-VH032

(R,S,S)-VH032 is a ligand for E3 ligase, specifically targeting the von Hippel-Lindau (VHL) protein. This compound inhibits the VHL/HIF-1α interaction and is pivotal in the synthesis of PROTACs. Notably, (R,S,S)-VH032 facilitates the development of tau-targeting small molecule PROTAC C004019, making it a valuable tool in research focused on targeted protein degradation and therapeutic applications.

Cat. No.

A80513

CAS No.

3070323-06-4

MS1262

MS1262 is a selective ligand for the E3 ubiquitin ligase SPOP, targeting the SPOP substrate GLP. This compound facilitates the recruitment of SPOP and is utilized in research to study ubiquitination processes and related signaling pathways. MS1262 serves as a precursor for the synthesis of MS479, further expanding its utility in chemical biology investigations.

Cat. No.

A80514

CAS No.

2359705-88-5

Lenalidomide-F

Lenalidomide-F is an E3 ligase ligand that targets cereblon, facilitating the development of PROTAC molecules. It is specifically designed for use with LWY713, a potent degrader of FLT3, exhibiting a DC50 value of 0.64 nM. This compound selectively induces the degradation of FLT3 through proteasome-dependent mechanisms. Lenalidomide-F is valuable for research applications focused on targeted protein degradation and the therapeutic potential of PROTACs in oncology.

Cat. No.

A80515

CAS No.

2582979-82-4

Glutarimide-(1-oxoisoindoline-5-carbaldehyde)

Glutarimide-(1-oxoisoindoline-5-carbaldehyde) functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of the cereblon protein, enabling targeted protein degradation approaches. It can be conjugated with specific target protein ligands through a linker, making it suitable for the development of PROTACs in proteomics research and drug discovery applications.

Cat. No.

A80516

CAS No.

1416990-10-7

Desamino lenalidomide-7-OH

Desamino lenalidomide-7-OH is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of cereblon to target proteins. This compound can be utilized in the design of PROTACs by linking it to a target protein ligand via a suitable linker. Its biological activity enables selective modulation of protein levels, making it a valuable tool in targeted protein degradation research applications.

Cat. No.

A80519

CAS No.

2446913-96-6

1-(4-Pip-Ph)-DHP-dione

1-(4-Pip-Ph)-DHP-dione is a ligand specifically designed for targeting E3 ligases. It plays a crucial role in the development of proteolysis-targeting chimeras (PROTACs), particularly in the synthesis of the HPK1 Degrader-2. This compound is valuable for research in targeted protein degradation and provides insights into E3 ligase-mediated cellular processes.

Cat. No.

A80520

CAS No.

2171519-15-4

Desamino lenalidomide-5-COOH

Desamino lenalidomide-5-COOH is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of cereblon to target proteins, enabling the formation of PROTACs (proteolysis-targeting chimeras) through a strategic linker attachment. Desamino lenalidomide-5-COOH is instrumental in studying targeted protein degradation pathways and has applications in drug discovery and therapeutic development.

Cat. No.

A80522

CAS No.

1352827-50-9

N-Methylated pomalidomide

Synonyms: Pomalidomide-methyl

N-Methylated pomalidomide acts as a selective ligand for cereblon (CRBN). This derivative of pomalidomide lacks the ability to recruit CRBN, making it a valuable negative control in studies involving pomalidomide. Additionally, N-methylated pomalidomide can be utilized in the synthesis of PROTACs, thereby assisting researchers in the exploration of targeted protein degradation pathways and mechanisms.

Cat. No.

A80523

CAS No.

1416990-09-4

Desamino lenalidomide-6-OH

Desamino lenalidomide-6-OH is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized in the synthesis of PROTACs by linking it to a target protein ligand through a suitable linker. Its applications include studies in targeted protein degradation and therapeutic strategies in cancer research.

Cat. No.

A80524

CAS No.

2358775-81-0

VH 101, thiol

VH 101, thiol serves as a selective VHL ligand, primarily utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound enables the targeted degradation of specific proteins by harnessing the ubiquitin-proteasome system, making it instrumental in drug discovery and therapeutic research. Its robust binding affinity and specificity towards VHL provide an effective tool for studies aimed at elucidating protein regulation mechanisms and developing novel treatments for various diseases.

Cat. No.

A80525

CAS No.

2641512-74-3

CRBN ligand-395

CRBN ligand-395 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated with a target protein ligand using a linker to form a proteolysis-targeting chimera (PROTAC), enabling the targeted degradation of specific proteins. CRBN ligand-395 is valuable in research applications involving protein degradation and modulation of cellular pathways.

Cat. No.

A80526

CAS No.

2244684-42-0

VH032-OH

VH032-OH is a ligand for the E3 ligase Von Hippel-Lindau (VHL), enabling targeted protein degradation. This compound can be utilized in the development of PROTACs (Proteolysis Targeting Chimeras) by linking it to target proteins. VH032-OH facilitates the selective ubiquitination and subsequent proteasomal degradation of substrate proteins, making it a valuable tool for investigating protein turnover and cellular regulation in various research applications.

Cat. No.

A80527

CAS No.

1472731-41-1

E3 ligase Ligand 56

E3 Ligase Ligand 56 is a specific ligand for the E3 ubiquitin ligase Cereblon, facilitating targeted protein degradation through proteolysis-targeting chimeras (PROTACs). This compound is instrumental in the synthesis of PROTAC CDK9 degrader-11, supporting research in targeted degradation mechanisms and their applications in cellular processes. Its utility in developing novel therapeutics makes it a valuable reagent for studies in oncology and pharmacology.

Cat. No.

A80528

CAS No.

444287-56-3

E3 ligase Ligand 23

E3 Ligase Ligand 23 is a cereblon binder that facilitates the degradation of Ikaros and Aiolos through the ubiquitin-proteasome pathway. This compound is instrumental in probing the mechanisms of targeted protein degradation and the role of cereblon in modulating protein levels. It is valuable for research applications involving the regulation of immune responses and hematological malignancies.

Cat. No.

A80529

CAS No.

1547162-44-6

Pomalidomide-6-OH

Pomalidomide-6-OH is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating targeted protein degradation through the proteolysis-targeting chimera (PROTAC) approach. This compound is instrumental in research applications focused on the selective modulation of protein levels within cellular contexts, contributing to studies in cancer and other diseases. Pomalidomide-6-OH serves as a valuable tool for investigating the biochemical pathways regulated by CRBN.

Cat. No.

A80531

CAS No.

2304753-45-3

CRBN ligand-788

CRBN ligand-788 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand via a linker, enabling the formation of a proteolysis-targeting chimeric (PROTAC) molecule. CRBN ligand-788 is primarily utilized in research focused on targeted protein degradation and harnessing the ubiquitin-proteasome system for therapeutic interventions.

Cat. No.

A80532

CAS No.

2758431-93-3

Pomalidomide 5'-piperazine-4-methylpiperidine dihydrochloride

Pomalidomide 5'-piperazine-4-methylpiperidine dihydrochloride is a ligand targeting cereblon (CRBN) within the E3 ubiquitin ligase complex. This compound facilitates the recruitment of CRBN, making it a valuable tool for the development of PROTACs (proteolysis-targeting chimeras) through linker conjugation. It holds potential applications in research related to targeted protein degradation and the study of protein homeostasis in various diseases, particularly in cancer.