E3 Ligase Ligands: Cereblon (CRBN) & VHL

Cat. No.: A80533

CAS No.: 2154343-24-3

CRBN ligand-661

CRBN ligand-661 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the targeted recruitment of the cereblon protein. This compound is designed for use in the development of PROTACs (Proteolysis Targeting Chimeras), linking to specific target proteins to promote their degradation via the ubiquitin-proteasome pathway. Its potential applications include studies in targeted protein degradation and the modulation of protein levels in various biological contexts.

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50 mg

$170.00

100 mg

$270.00

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Cat. No.: A80534

CAS No.: 2287259-68-9

Desamino lenalidomide-COOH

Desamino lenalidomide-COOH is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the targeted regulation of protein degradation. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (Proteolysis Targeting Chimera), enabling the selective modulation of protein functions in cellular and in vivo studies. It is a valuable tool for research applications in protein homeostasis and therapeutic development.

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5 mg

$40.00

10 mg

$65.00

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Cat. No.: A80535

CAS No.: 911109-85-8

(S)-Thalidomide 4-fluoride

(S)-Thalidomide 4-fluoride is a selective ligand for the cereblon (CRBN) E3 ligase. This compound is utilized in the synthesis of DeDPP4, making it a valuable tool in research related to protein degradation and the development of targeted therapeutics. Its interaction with the E3 ligase pathway underscores its potential applications in cellular biology and drug discovery initiatives.

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Cat. No.: A80536

CAS No.: 2768326-37-8

C5 Lenalidomide-CH3

C5 Lenalidomide-CH3 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker to generate a PROTAC, thereby enabling targeted protein degradation. Its unique mechanism offers valuable applications in research focused on protein modulation and degradation pathways.

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Cat. No.: A80537

CAS No.: 2866307-09-5

Desamino lenalidomide-5-CO

Desamino lenalidomide-5-CO is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the recruitment of the CRBN protein. This compound can be conjugated to target protein ligands through a linker to facilitate the formation of proteolysis-targeting chimeras (PROTACs). Its application in protein degradation studies makes it a valuable tool for exploring therapeutic strategies in various diseases, including cancer.

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Cat. No.: A80540

CAS No.: 2616540-83-9

Thalidomide-pyrrolidine

Thalidomide-pyrrolidine is a ligand for E3 ligases, facilitating targeted protein degradation via the PROTAC technology. This compound is instrumental in the synthesis of PROTAC ARD-1676, which enables selective modulation of protein levels in cellular systems. Thalidomide-pyrrolidine is valuable for research applications focused on therapeutic interventions in various diseases by leveraging the ubiquitin-proteasome pathway.

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3-(4-Bromo-2-fluorophenyl)piperidine-2,6-dione

Cat. No.: A80541

CAS No.: 2924092-66-8

3-(4-Bromo-2-fluorophenyl)piperidine-2,6-dione

3-(4-Bromo-2-fluorophenyl)piperidine-2,6-dione is an effective ligand for the CRBN-type E3 ubiquitin ligase, facilitating targeted protein degradation through the formation of PROTACs (Proteolysis Targeting Chimeras). This compound is instrumental in studies focused on ubiquitin-mediated proteolysis and can be utilized in various research applications aimed at elucidating protein function and regulation. Its unique structural features enable specific binding interactions that are crucial for the development of innovative therapeutic strategies.

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25 mg

$50.00

50 mg

$80.00

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Cat. No.: A80542

CAS No.: 2713620-89-2

CRBN ligand-617

CRBN ligand-617 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of CRBN to target proteins. This compound can be conjugated to a ligand that binds to a specific target protein through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). CRBN ligand-617 is applicable in studies focused on targeted protein degradation and has significant potential in drug discovery and therapeutic development.

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5 mg

$80.00

10 mg

$130.00

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Cat. No.: A80543

CAS No.: 2241669-88-3

E3 ligase Ligand 18

E3 Ligase Ligand 18 is a selective ligand for E3 ubiquitin ligases, facilitating the targeted degradation of proteins through the ubiquitin-proteasome system. When conjugated to a target protein via a linker, it forms a PROTAC (proteolysis-targeting chimera), which effectively induces ubiquitination and subsequent degradation of cancer-associated proteins. This reagent is valuable in research focused on protein degradation pathways and may contribute to therapeutic strategies for cancer treatment.

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1 mg

$45.00

5 mg

$105.00

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Cat. No.: A80544

CAS No.: 2616553-33-2

Thalidomide-(2)piperidine

Thalidomide-(2)piperidine is a potent E3 ligase ligand that plays a critical role in targeted protein degradation. This compound is valuable for the synthesis of proteolysis-targeting chimeras (PROTACs), facilitating the selective degradation of proteins of interest in cellular models. Its unique mechanism of action makes it a powerful tool in chemical biology and drug discovery research.

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5 mg

$65.00

10 mg

$105.00

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Cat. No.: A80545

CAS No.: 2616553-35-4

Thalidomide-pyrrolidine hydrochloride

Thalidomide-pyrrolidine hydrochloride is an E3 ligase ligand that serves as a key building block for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates targeted protein degradation by engaging with E3 ligases, offering a valuable tool for studies in protein regulation and the development of novel therapeutic strategies. Its application in chemical biology makes it an important reagent for researchers exploring targeted degradation pathways.

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5 mg

$20.00

10 mg

$30.00

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Lenalidomide-4-aminomethyl hydrochloride

Cat. No.: A80547

CAS No.: 444289-05-8

Lenalidomide-4-aminomethyl hydrochloride

Lenalidomide-4-aminomethyl hydrochloride is a derivative of Lenalidomide that functions as a ligand for cereblon (CRBN), a component of the E3 ubiquitin ligase complex. This compound facilitates the recruitment of CRBN protein, enabling targeted protein degradation. It can be utilized as a building block in the development of proteolysis-targeting chimeras (PROTACs) for various therapeutic applications in cancer research and other disease models.

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5 mg

$25.00

10 mg

$40.00

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Cat. No.: A80548

CAS No.: 55003-81-1

CRBN ligand-9

CRBN ligand-9 is a selective ligand targeting cereblon (CRBN) with a binding affinity (Ki) of 8.9 μM. This compound is designed for use in the synthesis of PROTACs (proteolysis targeting chimeras), facilitating the targeted degradation of specific proteins. CRBN ligand-9 serves as an essential tool for research in drug discovery and development, particularly in studies focused on targeted protein degradation mechanisms.

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Cat. No.: A80549

CAS No.: 2703915-71-1

E3 ligase Ligand 51

E3 Ligase Ligand 51 functions as a ligand for the E3 ligase CRBN, facilitating targeted protein degradation through the synthesis of PROTACs, specifically BTK Degrader-12. This compound plays a crucial role in the research of protein homeostasis, allowing for the selective degradation of target proteins. Its application is significant in the study of various diseases, including cancer, by modulating protein levels in cellular contexts.

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Cat. No.: A80550

CAS No.: 2413035-43-3

SJF-0661

SJF-0661 is a variant of the von Hippel-Lindau (VHL) protein ligand that lacks the capacity for targeted degradation. Serving as an essential control reagent, it is useful for studies involving VHL ubiquitin ligase ligands. This compound is synthesized by inverting the stereocenter of the critical hydroxyproline moiety in the original VHL ligand, allowing researchers to evaluate the specific activities of VHL ligands in various biological contexts.

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Cat. No.: A80551

CAS No.: 1448188-69-9

VL285 Phenol

VL285 Phenol is a phenol-based analog of VL285, serving as a ligand for the E3 ubiquitin ligase VHL. This compound enables the synthesis of HaloPROTAC3, facilitating the degradation of HaloTag7 fusion proteins with an IC50 of 0.34 μM. It is a valuable tool for research applications involving targeted protein degradation and the study of protein homeostasis in cellular systems.

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5 mg

$75.00

10 mg

$125.00

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Cat. No.: A80552

CAS No.: 2883704-28-5

CRBN ligand-187

CRBN ligand-187 is a potent CRBN-type E3 ubiquitin ligase ligand that plays a crucial role in the modulation of ubiquitination processes. This compound has been utilized for the synthesis of TQ-3959, facilitating research in targeted protein degradation and cellular signaling pathways. Its ability to engage the CRBN ligase offers valuable insights for studies involving protein homeostasis and therapeutic interventions in various diseases.

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5 mg

$380.00

10 mg

$630.00

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Cat. No.: A80553

CAS No.: 2304754-82-1

CRBN ligand-789

CRBN ligand-789 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound is designed for use in the development of PROTACs (proteolysis-targeting chimeras) by enabling the targeted degradation of specific proteins when linked to a target protein ligand. Its application is significant in chemical biology and therapeutic research, providing a valuable tool for studying protein regulation and degradation pathways.

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Cat. No.: A80554

CAS No.: 2888604-15-5

CRBN ligand-774

CRBN ligand-774 is a ligand specifically designed for the E3 ubiquitin ligase cereblon (CRBN). It effectively recruits the cereblon protein and can be utilized in the development of proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through a suitable linker. This compound is instrumental in research applications focusing on targeted protein degradation and the modulation of cellular pathways.

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Cat. No.: A80555

CAS No.: 1486115-10-9

CRBN ligand-206

CRBN ligand-206 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN for targeted ubiquitination. This compound can be conjugated with a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimeras). CRBN ligand-206 is instrumental in studies aimed at regulating protein degradation pathways and understanding ubiquitin-mediated processes in cellular functions.

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Cat. No.: A80556

CAS No.: 1918158-58-3

5-Fluoro-lenalidomide

5-Fluoro-lenalidomide is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand using a linker to create a proteolysis-targeting chimera (PROTAC). Its ability to mediate targeted protein degradation makes it a valuable tool in the study of protein homeostasis and therapeutic development.

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Cat. No.: A80559

CAS No.: 2412439-22-4

Desamino lenalidomide-6-propyne

Desamino lenalidomide-6-propyne is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC. Its applications include targeted protein degradation and modulation of cell signaling pathways for research in various biological contexts.

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Cat. No.: A80562

CAS No.: 2618349-23-6

CRBN ligand-891

CRBN ligand-891 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized to conjugate a target protein ligand through a linker, enabling the development of PROTAC molecules for targeted protein degradation studies. Its application is particularly relevant in drug discovery and the investigation of cellular pathways involving protein homeostasis.

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Cat. No.: A80564

CAS No.: 2438240-74-3

Desamino lenalidomide-6-Br-5-F

Desamino lenalidomide-6-Br-5-F is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in targeted protein degradation assays. This compound can be conjugated to a target protein ligand using a linker to create a proteolysis-targeting chimera (PROTAC). Its versatile functionality makes it an essential tool for researchers investigating protein regulation and degradation pathways.

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Cat. No.: A80565

CAS No.: 1531527-98-6

CRBN ligand-884

CRBN ligand-884 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC, enabling targeted protein degradation. It serves as a crucial tool for studies in protein regulation, cancer therapeutics, and other areas involving targeted protein modulation.

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