Catalog No.
Product Name
Application
Product Information
Citations
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Ligand for E3 Ligase
CRBN ligand-453 is an E3 ubiquitin ligase ligand that specifically targets cereblon (CRBN) to facilitate its recruitment. This compound is designed to be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). It provides a powerful tool for targeted protein degradation studies and is applicable in research aimed at modulating protein levels in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-369 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of proteolysis-targeting chimeras (PROTACs). CRBN ligand-369 is instrumental in studies focused on targeted protein degradation and therapeutic applications in various diseases. -
Ligand for E3 Ligase
CRBN Ligand-382 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the development of proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through a suitable linker. Its application in targeted protein degradation research enables the exploration of innovative therapeutic strategies for various diseases. -
Ligand for E3 Ligase
CRBN ligand-208 is a small-molecule ligand targeting the E3 ubiquitin ligase cereblon (CRBN). It is designed to facilitate the recruitment of CRBN to target proteins, enabling targeted protein degradation through PROTAC technology. This compound is applicable in research focusing on protein regulation and cellular signaling pathways, providing a valuable tool for drug discovery and development. -
Ligand for E3 Ligase
CRBN ligand-753 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. By attaching this compound to a target protein ligand through a linker, it can be utilized in the development of PROTACs (proteolysis-targeting chimeras). This compound is particularly valuable in research focused on targeted protein degradation and investigating the function of specific proteins involved in various biological processes. -
Ligand for E3 Ligase
CRBN ligand-686 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is designed to be conjugated with a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). It has potential applications in targeted protein degradation studies and investigating protein homeostasis in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-478 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (Proteolysis Targeting Chimeras). Its utility in controlling protein degradation makes it a valuable reagent for research applications in targeted protein modulation and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-228 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein for targeted protein degradation. It can be conjugated with a target protein ligand through a linker to generate a PROTAC (proteolysis-targeting chimera). This compound is instrumental in studies aimed at exploring the degradation of specific proteins and developing novel therapeutic strategies in cancer and other diseases. -
E3 Ligase Activator
Thalidomide-5-Br,6-F is a Thalidomide analogue functioning as an E3 ligase activator, promoting the ubiquitination of target proteins for proteolytic degradation. This compound enhances cellular pathways by modulating protein turnover, making it valuable in studies related to protein homeostasis and targeted degradation. Its unique structural features allow for potential further derivatization through substitution at the fluorine or bromine positions, offering avenues for the development of novel reagents. -
Ligand for E3 Ligase
CRBN ligand-620 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC, which enhances targeted protein degradation. CRBN ligand-620 is relevant for research applications in protein modulation and therapeutic development, particularly in the study of protein homeostasis. -
Ligand for E3 Ligase
CRBN ligand-304 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). CRBN ligand-304 is instrumental in studying protein degradation pathways and the development of targeted therapeutics in cancer research and other therapeutic areas. -
Ligand for E3 Ligase
CRBN ligand-376 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the development of PROTACs by linking it to a target protein ligand through a suitable linker. Its application in targeted protein degradation provides valuable tools for elucidating protein functions and advancing therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-552 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of the CRBN protein, enabling the targeted degradation of specific proteins in cellular systems. This compound can be utilized in the design of PROTACs (proteolysis-targeting chimeras) by linking it to a target protein ligand through a suitable linker, making it a valuable tool in drug discovery and development. -
Ligand for E3 Ligase
CRBN ligand-511 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the targeted recruitment of CRBN. This compound can be conjugated to target protein ligands through a linker to create proteolysis-targeting chimeras (PROTACs). Its application in degrading specific proteins makes it a valuable tool in chemical biology and therapeutic development for modulating cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-359 is a specialized ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the recruitment of the cereblon protein for targeted degradation. This compound can be conjugated to a target protein ligand through a linker to construct a PROTAC, facilitating the selective modulation of protein levels in cellular studies. Its application in protein degradation research makes it a valuable tool for investigating protein function and developing novel therapeutic strategies. -
Ligands for E3 Ligase
CRBN ligand-111 acts as a ligand for the CRBN E3 ubiquitin ligase, facilitating targeted protein degradation through PROTAC (proteolysis-targeting chimeras) technology. This compound is vital for research focused on the modulation of ubiquitin-proteasome pathways, enabling the selective degradation of proteins involved in various cellular processes. Its application is particularly significant in studies aimed at therapeutic development, including cancer biology and neurodegenerative diseases. -
Thalidomide Analog
5-(2-Chloroacetamide) thalidomide is a Thalidomide analog that functions as an E3 ligase recruiter, facilitating the ubiquitination and targeted degradation of specific proteins. The inclusion of a chloroacetamide moiety enhances its reactivity towards thiol groups, potentially increasing its efficacy in modulating protein degradation pathways. This compound is of interest for research applications in targeted protein therapy and cancer biology, providing insights into the mechanisms of protein homeostasis. -
pVHL Ligand
VHL Ligand 35 is a selective ligand of the von Hippel-Lindau protein (pVHL) E3 ubiquitin ligase with a dissociation constant (Kd) of 0.291 μM. This compound effectively disrupts the protein-protein interaction between pVHL and hypoxia inducible factor 1α (HIF-1α), which is critical for regulating cellular responses to hypoxia. VHL Ligand 35 is valuable for research applications involving hypoxia signaling pathways and cancer biology, particularly in studies targeting the mechanisms of HIF regulation. -
Ligand for E3 Ligase
CRBN ligand-366 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). Its utility in protein degradation strategies makes it valuable for research in protein homeostasis and targeted therapeutics. -
Ligand for E3 Ligase
CRBN Ligand-723 is an efficient ligand targeting the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of the cereblon protein and is designed to be conjugated to a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimera). It is valuable for research applications involving targeted protein degradation and cellular signaling pathways. -
Ligand for E3 Ligase
CRBN ligand-458 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound is designed for use in the development of Proteolysis Targeting Chimeras (PROTACs) by linking to target protein ligands through a suitable linker. Its application enables targeted degradation of specific proteins, providing valuable tools for research in cancer biology and drug discovery. -
Ligand for E3 Ligase
CRBN ligand-522 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), serving as a tool for targeted protein degradation. It facilitates the recruitment of cereblon to specific target proteins through a linking mechanism, enabling the formation of PROTACs (proteolysis-targeting chimeras). This compound is valuable for research applications aimed at elucidating the role of targeted degradation in cellular processes and for drug discovery strategies focusing on protein modulation. -
Ligand for E3 Ligase
Desamino lenalidomide-6-C-COOH is a ligand for E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in biochemical assays. This compound can be conjugated with a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC), enabling targeted protein degradation. Its applications in drug development and cellular studies enhance understanding of protein regulation and therapeutic strategies. -
Ligands for E3 Ligase
CRBN ligand-76 is a ligand for the CRBN E3 ubiquitin ligase, facilitating the development of PROTAC (Proteolysis Targeting Chimeras). This compound engages specifically with the CRBN E3 ligase, promoting ubiquitination and degradation of target proteins. Its application in targeted protein degradation offers potential for therapeutic intervention in various diseases, including cancer and neurodegenerative disorders. -
Ligands for E3 Ligase
CRBN ligand-148 is an E3 ubiquitin ligase ligand specifically targeting cereblon (CRBN). This compound facilitates the development of proteolysis-targeting chimeras (PROTACs) by promoting the ubiquitination and subsequent degradation of target proteins. Its biological activity is leveraged in research focused on targeted protein degradation and the modulation of cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-606 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of the CRBN protein, enabling targeted protein degradation through the formation of PROTACs when linked to specific target protein ligands. It is particularly useful in the study of protein homeostasis and degradation pathways, making it valuable for various research applications in cellular biology and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-298 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the selective recruitment of CRBN to target proteins. By facilitating the formation of a PROTAC (proteolysis-targeting chimera), CRBN ligand-298 functions to promote targeted protein degradation, making it a valuable tool for studies in protein regulation and therapeutic development. This reagent is essential for researchers investigating the therapeutic potential of targeted protein degradation pathways. -
Ligand for E3 Ligase
CRBN ligand-371 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC). CRBN ligand-371 is useful in studies involving targeted protein degradation and the modulation of cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-570 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the cereblon protein to target proteins. This compound can be utilized in the design of Proteolysis Targeting Chimeras (PROTACs) by linking it to specific target protein ligands through an appropriate linker. It is a valuable tool for studying targeted protein degradation and the therapeutic potential of modulating protein levels within cellular systems. -
Ligands for E3 Ligase
CRBN ligand-14 is a ligand targeting the CRBN E3 ubiquitin ligase, facilitating the formation of PROTACs (PROteolysis TArgeting Chimeras). This compound plays a crucial role in targeted protein degradation, enabling the selective elimination of proteins of interest within cellular systems. It is particularly valuable in drug discovery and development, providing insights into protein regulation and therapeutic interventions in various diseases. -
Ligand for E3 Ligase
CRBN ligand-389 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the development of proteolysis-targeting chimeras (PROTACs) by linking to target protein ligands through a suitable linker. The application of CRBN ligand-389 in research may aid in the modulation of protein degradation pathways and the exploration of targeted therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-735 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), functioning to recruit the CRBN protein. This compound can be conjugated with a target protein ligand through a linker, facilitating the formation of a PROTAC (proteolysis-targeting chimera). CRBN ligand-735 is essential for research in targeted protein degradation and the development of novel therapeutic strategies that exploit the ubiquitin-proteasome system. -
Ligand for E3 Ligase
(S,R,R)-VH032 hydrochloride is a selective ligand for the von Hippel-Lindau (VHL) E3 ligase. This compound facilitates the targeted degradation of proteins by enabling the formation of proteolysis-targeting chimeras (PROTACs) when conjugated to specific target protein ligands through a linker. Its unique mechanism allows for the modulation of cellular protein levels, making it a valuable tool in biochemical research and drug discovery applications. -
Ligand for E3 Ligase
CRBN ligand-762 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein for ubiquitination processes. This compound can be conjugated with target protein ligands through a linker to create proteolysis-targeting chimeras (PROTACs). Its application in targeted protein degradation makes it a valuable tool for studying cellular mechanisms and therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-350 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein to target proteins. This compound is engineered for use in the development of Proteolysis Targeting Chimeras (PROTACs), enabling targeted protein degradation and therapeutic applications in various disease models. Its utility in chemical biology supports research aimed at elucidating protein interactions and regulatory mechanisms. -
Ligand for E3 Ligase
CRBN ligand-545 is an E3 ubiquitin ligase cereblon (CRBN) ligand that effectively recruits the cereblon protein. This compound facilitates the development of proteolysis-targeting chimeras (PROTACs) by enabling linkages to target protein ligands via a suitable linker. Its application in targeted protein degradation research underscores its potential in therapeutic development for various diseases. -
Ligand for E3 Ligase
CRBN ligand-311 is a ligand that specifically targets the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of the CRBN protein, enabling the construction of Proteolysis Targeting Chimeras (PROTACs) when linked to target protein ligands through a suitable linker. CRBN ligand-311 is instrumental in studies focused on protein degradation and targeted therapeutic strategies in cancer and other diseases. -
Ligand for E3 Ligase
CRBN ligand-759 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the CRBN protein. It can be utilized in the development of proteolysis-targeting chimeras (PROTACs) by attaching it to a target protein ligand through a linker. This compound is valuable for research applications aimed at studying targeted protein degradation and elucidating cellular mechanisms involving CRBN. -
Ligand for E3 Ligase
Desamino lenalidomide-6-I functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This reagent can be conjugated with a target protein ligand through a suitable linker to create a PROTAC (Proteolysis Targeting Chimeras), which can enhance targeted protein degradation. It is valuable in research applications focused on ubiquitin-mediated proteolysis and drug development. -
Ligand for E3 Ligase
CRBN ligand-613 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the recruitment of the cereblon protein. This compound can be utilized in the design of proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through a suitable linker. It assists in the targeted degradation of proteins, facilitating valuable research in protein regulation and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-499 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized to conjugate with target protein ligands through a linker, enabling the formation of PROTACs (proteolysis-targeting chimeras). CRBN ligand-499 is valuable for studies in targeted protein degradation and therapeutic development in various diseases. -
Ligand for E3 Ligase
CRBN ligand-664 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker, enabling the development of proteolysis-targeting chimeras (PROTACs). Its use in research applications provides a powerful tool for targeted protein degradation and modulation of cellular functions. -
Ligand for E3 Ligase
Desamino lenalidomide-7-propyne is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC). Its ability to selectively induce target protein degradation makes it valuable in studies of protein regulation and therapeutic development for various diseases. -
Ligand for E3 Ligase
CRBN ligand-323 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be effectively utilized to tether a target protein ligand through a linker, enabling the construction of proteolysis-targeting chimeras (PROTACs). Its application in targeted protein degradation offers valuable insights for drug discovery and therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-462 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. By linking CRBN ligand-462 to a specific target protein ligand via a suitable linker, researchers can design and synthesize PROTACs (Proteolysis Targeting Chimeras), enabling targeted degradation of proteins of interest. This reagent is valuable in studies involving protein regulation, cellular signaling pathways, and potential therapeutic development in diseases associated with protein misfolding or dysregulation. -
Ligand for E3 Ligase
CRBN ligand-756 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. It is designed for use in the development of PROTACs (Proteolysis Targeting Chimeras) by linking to a target protein ligand through a suitable linker. This compound is essential for studying targeted protein degradation mechanisms and advancing research in cellular protein regulation. -
Thalidomide Analog
Thalidomide-4,5-F is a fluorinated analogue of Thalidomide, primarily acting through the promotion of protein ubiquitinylation. This modification can enhance the degradation of target proteins, making it a valuable tool for research in cellular regulation and signaling pathways. The compound's unique fluorinated structure allows for further derivatization at the fluorine sites, expanding its potential applications in medicinal chemistry and pharmaceutical development. -
Ligand for E3 Ligase
CRBN ligand-769 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), crucial for facilitating targeted protein degradation. It effectively recruits the cereblon protein, allowing for the development of bifunctional molecules when conjugated with target protein ligands through a linker. This compound is valuable in research focused on proteolysis targeting chimeras (PROTACs) and elucidating protein homeostasis. -
Ligand for E3 Ligase
CRBN ligand-254 is a ligand that targets the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand through a linker to create a PROTAC (Proteolysis Targeting Chimera), enabling targeted degradation of specific proteins. CRBN ligand-254 is valuable in research related to protein homeostasis and therapeutic interventions through targeted protein modulation. -
Ligands for E3 Ligase
Thalidomide-C-amide-C5-amine functions as a ligand for E3 ligases, facilitating targeted protein degradation in cellular contexts. This compound is specifically utilized in the synthesis of PROTAC BET Degrader-10, enabling selective modulation of BET proteins. Its applications extend to studies in protein homeostasis, cancer research, and the development of novel therapeutic strategies.
