E3 Ligase Ligands

Cat. No.

A80566

CAS No.

2446913-97-7

CRBN ligand-704

CRBN ligand-704 is a ligand for the E3 ubiquitin ligase cereblon (CRBN). It effectively recruits the CRBN protein for targeted protein degradation applications, facilitating the development of Proteolysis Targeting Chimeras (PROTACs). Its utility in research enables the selective modulation of protein levels, making it a valuable tool for studies in protein homeostasis and therapeutic development.

Cat. No.

A80568

CAS No.

2903425-10-3

CRBN ligand-733

CRBN ligand-733 is a small molecule ligand targeting the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN, allowing for the targeted degradation of specific proteins when conjugated with a target protein ligand through a linker to create a PROTAC. This compound is valuable in research applications aimed at understanding protein function and developing protein degradation strategies in therapeutic contexts.

Cat. No.

A80569

CAS No.

2287267-33-6

Desamino lenalidomide-7-F

Desamino lenalidomide-7-F is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of cereblon to target proteins, allowing for the targeted degradation of specific intracellular proteins through the formation of PROTACs (Proteolysis Targeting Chimeras). This compound is valuable for researching protein regulation and therapeutic applications in oncology and other diseases.

Cat. No.

A80570

CAS No.

2654822-43-0

CRBN ligand-838

CRBN ligand-838 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to effectively recruit the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC, enabling targeted degradation of specific proteins. CRBN ligand-838 is valuable for research applications in protein homeostasis and the study of targeted protein degradation pathways.

Cat. No.

A80571

CAS No.

2369068-46-0

Thalidomide-4-carbaldehyde

Thalidomide-4-carbaldehyde is a Thalidomide analogue featuring an aldehyde functional group. This compound is known to recruit E3 ligases, facilitating the ubiquitination and subsequent proteolysis of target proteins, making it a valuable tool in studying protein degradation pathways. Its highly reactive aldehyde group engages in reductive amination reactions with amine nucleophiles, offering diverse applications in chemical biology and medicinal chemistry research.

Cat. No.

A80572

CAS No.

2375260-16-3

Desamino lenalidomide-4-C-COOH

Desamino lenalidomide-4-C-COOH is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in targeted protein degradation applications. This compound can be conjugated to a target protein ligand through a linker, enabling the creation of Proteolysis Targeting Chimeras (PROTACs). Its utilization in research provides insights into protein regulation mechanisms and therapeutic strategies in diseases influenced by protein homeostasis.

Cat. No.

A80573

CAS No.

1447701-63-4

Thalidomide-5-carbaldehyde

Thalidomide-5-carbaldehyde is a Thalidomide analog featuring an aldehyde functional group. It actively interacts with E3 ligases, facilitating the ubiquitination and degradation of specific target proteins, thereby contributing to cellular regulation. The aldehyde group exhibits high reactivity towards amine nucleophiles, enabling reductive amination and other chemical modifications, making it a valuable tool for research in protein degradation pathways and therapeutic development.

Cat. No.

A80574

CAS No.

1502483-16-0

CRBN ligand-883

CRBN ligand-883 is a ligand that targets the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific protein partners. This compound can be utilized in the synthesis of PROTACs (proteolysis-targeting chimeras) by linking it to a target protein ligand through a suitable linker. CRBN ligand-883 serves as a valuable tool for research applications aimed at studying targeted protein degradation and modulatory effects in cellular processes.

Cat. No.

A80575

CAS No.

2244568-06-5

Thalidomide-1-Me,4-OH

Thalidomide-1-Me,4-OH is an analogue of Thalidomide, featuring an additional methyl group on the glutarimide moiety. This modification abolishes its interaction with the E3 ubiquitin ligase, cereblon (CRBN), which is critical for the ubiquitination and subsequent proteolytic degradation of target proteins. Thalidomide itself is well-known for its immunomodulatory and anti-inflammatory properties, making Thalidomide-1-Me,4-OH a valuable tool for investigating the molecular mechanisms of CRBN-mediated drug action and cellular protein regulation in research applications.

Cat. No.

A80576

CAS No.

3059455-81-8

CRBN ligand-47

CRBN ligand-47 is a potent ligand for the CRBN-type E3 ubiquitin ligase, facilitating targeted protein degradation through the formation of PROTACs (Proteolysis Targeting Chimeras). This compound exhibits effective recruitment of E3 ligase activity, making it valuable for research in protein homeostasis and therapeutic interventions in various diseases. Its role in modulating ubiquitin-mediated pathways underscores its utility in chemical biology and drug discovery applications.

Cat. No.

A80577

CAS No.

2713619-96-4

CRBN ligand-618

CRBN ligand-618 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be connected to a target protein ligand through a linker, enabling the development of PROTACs (proteolysis-targeting chimeras). CRBN ligand-618 is valuable for research applications focused on targeted protein degradation and modulation of cellular pathways.

Cat. No.

A80578

CAS No.

1512414-62-8

CRBN ligand-882

CRBN ligand-882 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a suitable linker to create a proteolysis-targeting chimera (PROTAC). Its application is particularly relevant in targeted protein degradation research and therapeutic development.

Cat. No.

A80579

CAS No.

2763749-29-5

N-Methyl-desamino lenalidomide-NH2

N-Methyl-desamino lenalidomide-NH2 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), playing a crucial role in targeted protein degradation. This compound facilitates the recruitment of cereblon to specific target proteins, enabling the development of PROTACs (proteolysis-targeting chimeras) for precision research applications. It serves as a valuable tool for studying proteasomal degradation pathways and expanding the scope of targeted therapies in drug discovery.

Cat. No.

A80580

CAS No.

83809-75-0

CRBN ligand-225

CRBN ligand-225 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). Its utility in targeted protein degradation makes it a valuable tool in chemical biology research and drug discovery applications.

Cat. No.

A80581

CAS No.

2925099-10-9

CRBN ligand-761

CRBN ligand-761 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). It is useful in research applications focused on targeted protein degradation and the modulation of cellular processes via ubiquitin-mediated pathways.

Cat. No.

A80582

CAS No.

2230957-36-3

Thalidomide-1-Me,5-F

Thalidomide-1-Me,5-F is a fluorinated E3 ligase activator that functions by promoting the ubiquitination of target proteins. This compound exhibits key biological activity in modulating protein degradation pathways, making it valuable for research in cellular signaling and therapeutic interventions. Additionally, Thalidomide-1-Me,5-F can serve as a substrate for further derivatization via nucleophilic aromatic substitution (SNAr) reactions.

Cat. No.

A80583

CAS No.

2377643-38-2

Hydrouracil-4-fluorobenzoate

Hydrouracil-4-fluorobenzoate is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized to conjugate with target protein ligands through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). Its application is significant in the study of protein degradation pathways and therapeutic development targeting specific proteins for degradation.

Cat. No.

A80584

CAS No.

2925071-04-9

CRBN ligand-430

CRBN ligand-430 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is designed for use in PROTAC (proteolysis targeting chimera) technology, allowing for targeted degradation of specific proteins when linked to a target protein ligand through a suitable linker. Its application is pivotal in the study of protein homeostasis and therapeutic development in diseases where protein dysregulation is a factor.

Cat. No.

A80585

CAS No.

2287262-43-3

Desamino lenalidomide-5-C-COOH

Desamino lenalidomide-5-C-COOH is a ligand for the E3 ubiquitin ligase cereblon (CRBN). It effectively recruits the cereblon protein, enabling the formation of targeted protein degraders. This compound can be connected to a target protein ligand through a linker, facilitating the development of proteolysis-targeting chimeras (PROTACs) for applications in drug discovery and biochemistry research.

Cat. No.

A80586

CAS No.

1243329-97-6

Lenalidomide hydrochloride

Synonyms: CC-5013 hydrochloride

Lenalidomide hydrochloride is an oral immunomodulatory agent targeting cereblon (CRBN), acting as a molecular glue. It promotes the selective ubiquitination and degradation of transcription factors IKZF1 and IKZF3 via the CRBN-CRL4 ubiquitin ligase complex. This mechanism effectively inhibits the growth of mature B-cell lymphomas, including multiple myeloma, while also inducing the release of IL-2 from T cells, making it valuable in cancer research and therapeutic applications.

Cat. No.

A80587

CAS No.

2876809-75-3

VHL Ligand 39

VHL Ligand 39 is a conjugate of the VHL E3 ligase, acting as a pivotal intermediate in the construction of PROTAC (proteolysis-targeting chimera) molecules. This compound facilitates targeted protein degradation by harnessing the ubiquitin-proteasome system, enabling researchers to modulate protein levels for various biological studies. Its applications extend to investigating cellular signaling pathways and therapeutic mechanisms involving targeted degradation of specific proteins.

Cat. No.

A80588

CAS No.

26581-83-9

2-(2,6-Dioxopiperidin-3-yl)phthalimidine NMe

2-(2,6-Dioxopiperidin-3-yl)phthalimidine NMe is an E3 ligase ligand specifically targeting CRBN. This compound features an additional methyl group on the glutarimide moiety of thalidomide, which disrupts its binding affinity to the E3 ligase. It serves as a negative control for the NAMPT degrader SIAIS630121, making it a valuable tool for research involving targeted protein degradation and molecular pathways regulated by E3 ligases.

Cat. No.

A80589

CAS No.

1010100-28-3

Lenalidomide-5-aminomethyl

Lenalidomide-5-aminomethyl is a cereblon (CRBN) ligand that facilitates the recruitment of the CRBN protein, enabling targeted cellular degradation. This compound can be utilized as a key component in the development of PROTACs (proteolysis-targeting chimeras), which harness the ubiquitin-proteasome system for the selective degradation of specific proteins. Its significant role in E3 ligase-mediated pathways makes it valuable for research in targeted protein modulation and therapeutic development.

Cat. No.

A80590

CAS No.

2375541-28-7

Aster-A Ligand-3

Aster-A Ligand-3 is a target protein ligand that acts as a critical component for the synthesis of PROTAC Aster-A degrader. This compound facilitates targeted protein degradation, making it valuable in the study of protein homeostasis and cellular signaling pathways. Its application is relevant in drug discovery and therapeutic development, particularly for diseases related to protein dysregulation.

Cat. No.

A80591

CAS No.

2911613-35-7

E3 ligase Ligand 26

E3 Ligase Ligand 26 is a selective ligand for E3 ubiquitin ligases, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the synthesis of the PROTAC SOS1 degrader, contributing to targeted protein degradation research. Its application extends to studies of cellular pathways and potential therapeutic interventions for various diseases through the modulation of protein levels.