Catalog No.
Product Name
Application
Product Information
Citations
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Ligand for E3 Ligase
CRBN ligand-570 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the cereblon protein to target proteins. This compound can be utilized in the design of Proteolysis Targeting Chimeras (PROTACs) by linking it to specific target protein ligands through an appropriate linker. It is a valuable tool for studying targeted protein degradation and the therapeutic potential of modulating protein levels within cellular systems. -
Ligands for E3 Ligase
CRBN ligand-14 is a ligand targeting the CRBN E3 ubiquitin ligase, facilitating the formation of PROTACs (PROteolysis TArgeting Chimeras). This compound plays a crucial role in targeted protein degradation, enabling the selective elimination of proteins of interest within cellular systems. It is particularly valuable in drug discovery and development, providing insights into protein regulation and therapeutic interventions in various diseases. -
Ligand for E3 Ligase
CRBN ligand-389 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the development of proteolysis-targeting chimeras (PROTACs) by linking to target protein ligands through a suitable linker. The application of CRBN ligand-389 in research may aid in the modulation of protein degradation pathways and the exploration of targeted therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-735 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), functioning to recruit the CRBN protein. This compound can be conjugated with a target protein ligand through a linker, facilitating the formation of a PROTAC (proteolysis-targeting chimera). CRBN ligand-735 is essential for research in targeted protein degradation and the development of novel therapeutic strategies that exploit the ubiquitin-proteasome system. -
Ligand for E3 Ligase
(S,R,R)-VH032 hydrochloride is a selective ligand for the von Hippel-Lindau (VHL) E3 ligase. This compound facilitates the targeted degradation of proteins by enabling the formation of proteolysis-targeting chimeras (PROTACs) when conjugated to specific target protein ligands through a linker. Its unique mechanism allows for the modulation of cellular protein levels, making it a valuable tool in biochemical research and drug discovery applications. -
Ligand for E3 Ligase
CRBN ligand-762 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein for ubiquitination processes. This compound can be conjugated with target protein ligands through a linker to create proteolysis-targeting chimeras (PROTACs). Its application in targeted protein degradation makes it a valuable tool for studying cellular mechanisms and therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-350 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein to target proteins. This compound is engineered for use in the development of Proteolysis Targeting Chimeras (PROTACs), enabling targeted protein degradation and therapeutic applications in various disease models. Its utility in chemical biology supports research aimed at elucidating protein interactions and regulatory mechanisms. -
Ligand for E3 Ligase
CRBN ligand-545 is an E3 ubiquitin ligase cereblon (CRBN) ligand that effectively recruits the cereblon protein. This compound facilitates the development of proteolysis-targeting chimeras (PROTACs) by enabling linkages to target protein ligands via a suitable linker. Its application in targeted protein degradation research underscores its potential in therapeutic development for various diseases. -
Ligand for E3 Ligase
CRBN ligand-311 is a ligand that specifically targets the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of the CRBN protein, enabling the construction of Proteolysis Targeting Chimeras (PROTACs) when linked to target protein ligands through a suitable linker. CRBN ligand-311 is instrumental in studies focused on protein degradation and targeted therapeutic strategies in cancer and other diseases. -
Ligand for E3 Ligase
CRBN ligand-759 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the CRBN protein. It can be utilized in the development of proteolysis-targeting chimeras (PROTACs) by attaching it to a target protein ligand through a linker. This compound is valuable for research applications aimed at studying targeted protein degradation and elucidating cellular mechanisms involving CRBN. -
Ligand for E3 Ligase
Desamino lenalidomide-6-I functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This reagent can be conjugated with a target protein ligand through a suitable linker to create a PROTAC (Proteolysis Targeting Chimeras), which can enhance targeted protein degradation. It is valuable in research applications focused on ubiquitin-mediated proteolysis and drug development. -
Ligand for E3 Ligase
CRBN ligand-613 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the recruitment of the cereblon protein. This compound can be utilized in the design of proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through a suitable linker. It assists in the targeted degradation of proteins, facilitating valuable research in protein regulation and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-499 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized to conjugate with target protein ligands through a linker, enabling the formation of PROTACs (proteolysis-targeting chimeras). CRBN ligand-499 is valuable for studies in targeted protein degradation and therapeutic development in various diseases. -
Ligand for E3 Ligase
CRBN ligand-664 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker, enabling the development of proteolysis-targeting chimeras (PROTACs). Its use in research applications provides a powerful tool for targeted protein degradation and modulation of cellular functions. -
Ligand for E3 Ligase
Desamino lenalidomide-7-propyne is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC). Its ability to selectively induce target protein degradation makes it valuable in studies of protein regulation and therapeutic development for various diseases. -
Ligand for E3 Ligase
CRBN ligand-323 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be effectively utilized to tether a target protein ligand through a linker, enabling the construction of proteolysis-targeting chimeras (PROTACs). Its application in targeted protein degradation offers valuable insights for drug discovery and therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-462 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. By linking CRBN ligand-462 to a specific target protein ligand via a suitable linker, researchers can design and synthesize PROTACs (Proteolysis Targeting Chimeras), enabling targeted degradation of proteins of interest. This reagent is valuable in studies involving protein regulation, cellular signaling pathways, and potential therapeutic development in diseases associated with protein misfolding or dysregulation. -
Ligand for E3 Ligase
CRBN ligand-756 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. It is designed for use in the development of PROTACs (Proteolysis Targeting Chimeras) by linking to a target protein ligand through a suitable linker. This compound is essential for studying targeted protein degradation mechanisms and advancing research in cellular protein regulation. -
Thalidomide Analog
Thalidomide-4,5-F is a fluorinated analogue of Thalidomide, primarily acting through the promotion of protein ubiquitinylation. This modification can enhance the degradation of target proteins, making it a valuable tool for research in cellular regulation and signaling pathways. The compound's unique fluorinated structure allows for further derivatization at the fluorine sites, expanding its potential applications in medicinal chemistry and pharmaceutical development. -
Ligand for E3 Ligase
CRBN ligand-769 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), crucial for facilitating targeted protein degradation. It effectively recruits the cereblon protein, allowing for the development of bifunctional molecules when conjugated with target protein ligands through a linker. This compound is valuable in research focused on proteolysis targeting chimeras (PROTACs) and elucidating protein homeostasis. -
Ligand for E3 Ligase
CRBN ligand-254 is a ligand that targets the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand through a linker to create a PROTAC (Proteolysis Targeting Chimera), enabling targeted degradation of specific proteins. CRBN ligand-254 is valuable in research related to protein homeostasis and therapeutic interventions through targeted protein modulation. -
Ligands for E3 Ligase
Thalidomide-C-amide-C5-amine functions as a ligand for E3 ligases, facilitating targeted protein degradation in cellular contexts. This compound is specifically utilized in the synthesis of PROTAC BET Degrader-10, enabling selective modulation of BET proteins. Its applications extend to studies in protein homeostasis, cancer research, and the development of novel therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-449 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be effectively connected to a target protein ligand through a linker to create a PROTAC (proteolysis targeting chimera). CRBN ligand-449 is valuable for research into targeted protein degradation and the development of innovative therapeutics. -
Ligand for E3 Ligase
CRBN ligand-572 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound can be utilized to construct proteolysis-targeting chimeras (PROTACs) by linking it to target protein ligands through a suitable linker. CRBN ligand-572 is essential in studying protein degradation pathways and offers potential applications in targeted protein modulation for therapeutic research. -
Ligand for E3 Ligase
CRBN ligand-318 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of CRBN to specific target proteins. This compound serves as a pivotal component in the development of PROTACs (proteolysis-targeting chimeras), enabling targeted protein degradation in cellular systems. Its unique ability to engage with CRBN makes it a valuable tool for investigating ubiquitin-proteasome pathway mechanisms and exploring new therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-619 is a ligand targeting the E3 ubiquitin ligase cereblon (CRBN), facilitating its recruitment for protein degradation processes. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera) for effective modulation of protein levels. CRBN ligand-619 is valuable for research applications in protein homeostasis, targeted therapy development, and the investigation of ubiquitin-proteasome system dynamics. -
Ligand for E3 Ligase
CRBN ligand-751 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the cereblon protein. This compound can be utilized in the development of PROTACs (proteolysis-targeting chimeras) by linking it to a target protein ligand through a suitable linker. CRBN ligand-751 is valuable for research applications in targeted protein degradation and the exploration of ubiquitin-proteasome system mechanisms. -
Ligand for E3 Ligase
CRBN ligand-421 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. It can be utilized to construct proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through an appropriate linker. This compound is valuable for studies involving targeted protein degradation and the modulation of protein levels within cellular systems. -
Ligand for E3 Ligase
CRBN ligand-615 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), utilized to recruit the CRBN protein in targeted protein degradation applications. It can be integrated with a target protein ligand through a linker, facilitating the formation of a PROTAC (proteolysis-targeting chimera). This compound enables selective degradation of specific proteins, making it valuable for research in areas such as cancer biology and targeted therapeutics. -
E3 Ligase Ligand
E3 ligase Ligand 66 is an E3 ligase ligand designed to specifically recruit inhibitor of apoptosis (IAP) proteins. This compound facilitates targeted protein degradation through the formation of PROTACs when conjugated with ligands such as SARS-CoV-2 Mpro ligand 1, enabling researchers to manipulate protein levels in cellular systems. Its applications extend to investigations in degradation pathways and therapeutic strategies against diseases, including viral infections. -
Ligand for E3 Ligase
CRBN ligand-638 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN to target proteins, enabling targeted protein degradation through the formation of PROTACs (proteolysis-targeting chimeras). This compound is essential for studies focused on selective protein modulation and degradation pathways, contributing to advancements in therapeutic research and development. -
Ligand for E3 Ligase
CRBN ligand-422 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be effectively conjugated to target protein ligands through a linker to create PROTACs, enabling targeted protein degradation. CRBN ligand-422 is valuable in research applications focused on proteolysis-targeting chimeras and the modulation of specific protein levels within cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-454 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. Its unique structure allows for conjugation with a target protein ligand through a linker, enabling the formation of a PROTAC. This compound is vital for studies focused on targeted protein degradation and can significantly contribute to the development of novel therapeutic strategies in cancer and other diseases linked to protein homeostasis. -
Ligand for E3 Ligase
CRBN ligand-588 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of the cereblon protein in targeted protein degradation applications. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). Its use in research promotes advancements in the development of targeted therapies through the modulation of protein levels in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-643 is a ligand designed to target the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. It can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). This compound is valuable for research applications focusing on targeted protein degradation and the modulation of cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-540 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of the CRBN protein. This compound is pivotal for the construction of PROTACs by enabling the linkage of target protein ligands through a suitable spacer. Its utility extends to targeted protein degradation studies, contributing to the exploration of protein regulation and therapeutic interventions in various biological contexts. -
Ligand for E3 Ligase
Hydrouracil-(4-Br-2,6-difluorobenzene) serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated with target protein ligands through linkers to create PROTAC molecules, which are pivotal in targeted protein degradation research. Its application in the development of novel therapeutic strategies highlights its significance in chemical biology and drug discovery. -
Ligand for E3 Ligase
CRBN ligand-357 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of cereblon, enabling targeted protein degradation when conjugated with a proximal ligand through a linker. This compound is valuable for researchers studying protein homeostasis and developing PROTACs for applications in targeted cancer therapies and other signaling pathways. -
Ligand for E3 Ligase
CRBN ligand-336 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of the CRBN protein to target proteins, enabling the design of proteolysis-targeting chimeras (PROTACs). This compound is essential for studies focused on targeted protein degradation and can be utilized in various research applications involving protein manipulation and regulation. -
Ligand for E3 Ligase
CRBN ligand-261 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), which facilitates the recruitment of CRBN to target proteins. This compound can be utilized in the design of PROTACs (proteolysis-targeting chimeras) by linking it to a target protein ligand through a suitable linker. Its applications in chemical biology include targeted degradation of specific proteins, thereby advancing research in drug development and protein homeostasis. -
Ligand for E3 Ligase
CRBN ligand-548 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized to form proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand via a suitable linker. Its application in targeted protein degradation research makes it a valuable tool for studying protein homeostasis and therapeutic interventions. -
Ligand for E3 Ligase
Hydrouracil-(4-CP) is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN in targeted protein degradation applications. This compound can be conjugated to a specific target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimeras). Hydrouracil-(4-CP) is instrumental in studies focusing on selective protein degradation and cellular protein turnover. -
Ligand for E3 Ligase
CRBN ligand-497 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be coupled with a ligand for a target protein through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). CRBN ligand-497 is utilized in research to explore targeted protein degradation pathways and to study the role of the ubiquitin-proteasome system in cellular regulation. -
Ligand for E3 Ligase
CRBN ligand-605 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound effectively recruits the cereblon protein, facilitating the formation of PROTAC molecules when linked to target protein ligands. CRBN ligand-605 is primarily utilized in studies involving targeted protein degradation, enabling researchers to explore therapeutic applications in cancer and other diseases. -
Ligand for E3 Ligase
CRBN ligand-529 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). CRBN ligand-529 is essential for studies involving targeted protein degradation and the investigation of cellular pathways influenced by ubiquitin-mediated proteolysis. -
Ligand for E3 Ligase
CRBN ligand-293 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be coupled with a target protein ligand through a linker to create a proteolysis targeting chimera (PROTAC). CRBN ligand-293 is essential for research applications aimed at studying targeted protein degradation and modulating cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-602 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein to target substrates. This compound can be utilized in the development of PROTACs (proteolysis-targeting chimeras) by linking it to a target protein ligand through a suitable linker. Its utility in targeted protein degradation makes it a valuable tool for researchers interested in modulating protein levels in cellular systems. -
Ligand for E3 Ligase
CRBN ligand-758 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized to link target protein ligands through a suitable linker, enabling the formation of PROTACs (proteolysis targeting chimeras). CRBN ligand-758 offers significant potential for applications in targeted protein degradation research and the development of novel therapeutic strategies. -
Ligand for E3 Ligase
CRBN Ligand-456 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. It is designed for use in the development of PROTACs by linking to target protein ligands through a suitable linker. This compound plays a crucial role in studying protein degradation pathways and offers potential in therapeutic applications involving targeted protein modulation. -
Ligand for E3 Ligase
CRBN ligand-442 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to target protein ligands through a linker to create a proteolysis-targeting chimera (PROTAC). Its application in targeted protein degradation makes it valuable for studying protein dynamics and potential therapeutic interventions.
