DNA-PK

Catalog No.Inhibitor Name DNA-PKOther
A10726PI-103
**
p110α,p110δ,p110β
A11098NU7441
***
mTOR,PI3K
A10729PIK-75
****
p110α,p110γ,p110δ
A12752NU7026
*
PI3K
A11207PP121
**
PDGFR,Hck,VEGFR
A13224KU-0060648
***
PI3Kδ,PI3Kβ,PI3Kα
A11778Compound 401
*
mTOR,PI3K
A13328ETP-46464
***
ATM, ATR, PI3Kα, mTOR
A15779CC-115
***
mTOR

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. PI-103

    Catalog No. A10726
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    PI3K Inhibitor
    PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α), and mTOR. Learn More
  2. CC-115

    Catalog No. A15779
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    mTOR/DNA-PK inhibitor
    CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM). Learn More
  3. NU7026

    Catalog No. A12752
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    DNA-PK inhibitor
    NU7026 is a novel DNA-dependent protein kinase inhibitor that potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia. Learn More
  4. ETP-46464

    Catalog No. A13328
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    ATR inhibitor
    ETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM. Learn More
  5. KU 0060648

    Catalog No. A13224
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    DNA-PK inhibitor
    KU0060648 is a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK), (IC50 = 8.6 nM); with 20-1000 fold selectivity for DNA-PK over other PIKKs and a panel of 60 kinases. KU-0060648 enhances HDR efficiency and attenuates NHEJ frequency. Learn More
  6. Compound 401

    Catalog No. A11778
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    DNA-PK inhibitor
    Compound 401 is a cell-permeable pyrimido-isoquinolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 280 nM) with ~19-fold selectivity over mTOR (IC50 = 5.3 μM). Learn More
  7. PIK-75

    Catalog No. A10729
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    PI3K Inhibitor
    PIK-75 is an imidazopyridine that selectively inhibits p110α with an IC50 value of 5.8 nM.2 It inhibits p110γ and p110β considerably less effectively with IC50 values of 0.076 µM and 1.3 µM, respectively. Learn More
  8. PP121

    Catalog No. A11207
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    PI3K Inhibitor
    PP121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR). Learn More
  9. NU-7441 (KU-57788)

    Catalog No. A11098
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    DNA-PK inhibitor
    NU-7441 (KU-57788) is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor. The IC50 values are 14, 1700, 5000, >100000 and >100000 nM for DNA-PK, mTOR, PI 3-K, ATM and ATR respectively. Learn More
  10. CCT251545

    Catalog No. A16216
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    Wnt inhibitor
    CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with IC50 value of 5 nM. Learn More
  11. NU6027

    Catalog No. A14136
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    ATR/CDK inhibitor
    NU6027 is a potent inhibitor of cellular ATR activity (IC(50)=6.7 μM) and enhanced hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner. Learn More

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