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| Catalog No. | Inhibitor Name | DNA-PK | Other |
|---|---|---|---|
| A10726 | PI-103 | ** | p110α,p110δ,p110β |
| A11098 | NU7441 | *** | mTOR,PI3K |
| A10729 | PIK-75 | **** | p110α,p110γ,p110δ |
| A12752 | NU7026 | * | PI3K |
| A11207 | PP121 | ** | PDGFR,Hck,VEGFR |
| A13224 | KU-0060648 | *** | PI3Kδ,PI3Kβ,PI3Kα |
| A11778 | Compound 401 | * | mTOR,PI3K |
| A13328 | ETP-46464 | *** | ATM, ATR, PI3Kα, mTOR |
| A15779 | CC-115 | *** | mTOR |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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PI-103
Catalog No. A10726 PI3K InhibitorPI-103 is a potent, cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α), and mTOR. Learn More -
NU-7441 (KU-57788)
Catalog No. A11098 DNA-PK inhibitorNU-7441 (KU-57788) is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor. The IC50 values are 14, 1700, 5000, >100000 and >100000 nM for DNA-PK, mTOR, PI 3-K, ATM and ATR respectively. Learn More -
PP121
Catalog No. A11207 PI3K InhibitorPP121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR). Learn More -
PIK-75 hydrochloride
Catalog No. A10729 PI3K InhibitorPIK-75 is an imidazopyridine that selectively inhibits p110α with an IC50 value of 5.8 nM.2 It inhibits p110γ and p110β considerably less effectively with IC50 values of 0.076 µM and 1.3 µM, respectively. Learn More -
Compound 401
Catalog No. A11778 DNA-PK inhibitorCompound 401 is a cell-permeable pyrimido-isoquinolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 280 nM) with ~19-fold selectivity over mTOR (IC50 = 5.3 μM). Learn More -
KU 0060648
Catalog No. A13224 DNA-PK inhibitorKU0060648 is a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK), (IC50 = 8.6 nM); with 20-1000 fold selectivity for DNA-PK over other PIKKs and a panel of 60 kinases. KU-0060648 enhances HDR efficiency and attenuates NHEJ frequency. Learn More -
ETP-46464
Catalog No. A13328 ATR inhibitorETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM. Learn More -
NU7026
Catalog No. A12752 DNA-PK inhibitorNU7026 is a novel DNA-dependent protein kinase inhibitor that potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia. Learn More -
CC-115
Catalog No. A15779 mTOR/DNA-PK inhibitorCC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM). Learn More -
CCT251545
Catalog No. A16216 Wnt inhibitorCCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with IC50 value of 5 nM. Learn More -
NU6027
Catalog No. A14136 ATR/CDK inhibitorNU6027 is a potent inhibitor of cellular ATR activity (IC(50)=6.7 μM) and enhanced hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner. Learn More -
AZD-7648
Catalog No. A20049 DNA-PK inhibitorAZD-7648 is a potent and selective DNA-PK inhibitor. Anti-tumor activity. Learn More
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