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PI3K Inhibitor

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Catalog No. A10729

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PIK-75 10mg A10729-10
PIK-75 25mg A10729-25
PIK-75 50mg A10729-50
PIK-75 100mg A10729-100

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PIK-75 is an imidazopyridine that selectively inhibits p110α with an IC50 value of 5.8 nM.2 It inhibits p110γ and p110β considerably less effectively with IC50 values of 0.076 µM and 1.3 µM, respectively.


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Publications citing Adooq Products
PIK-75 Citations (1)
  • Pridham KJ,et al. PIK3CB/p110汕 is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 29016844

Chemical Information

Catalog Num A10729
Actions Inhibitor
M. Wt 488.7
Formula C16H14BrN5O4S.HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 372196-77-5
Synonyms PIK75
SMILES code CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)/N=C/C2=CN=C3N2C=C(C=C3)Br.Cl
Chemical Name 2-​methyl-​5-​nitro-​2-​[(6-​bromoimidazo[1,​2-​a]pyridin-​3-​yl)methylene]-​1-​methylhydrazide-​benzenesulfonic acid

Biological Activity

PIK-75 is an imidazopyridine that selectively inhibits p110α with an IC50 value of 5.8 nM.2 It inhibits p110γ and p110β considerably less effectively with IC50 values of 0.076 µM and 1.3 µM, respectively.
DNA-PK (Cell-free assay) p110α (Cell-free assay) p110γ (Cell-free assay) p110δ (Cell-free assay) p110β (Cell-free assay)
2 nM5.8 nM76 nM0.51 μM1.3 μM


Solubility (25°C)* In vitro DMSO 3 mg/mL (6.13 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.46 mL 102.31 mL 204.62mL
0.5 mM 4.09 mL 20.46 mL 40.92 mL
1 mM 2.05 mL 10.23 mL 20.46 mL
5 mM 0.41 mL 2.05 mL 4.09 mL

*The above data is based on the productmolecular weight 488.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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