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Publications citing Adooq Products
PIK-75 Citations (1)
- Pridham KJ, .et al. PIK3CB/p110β is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844
Chemical Information
| Catalog Num | A10729 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 488.7 |
| Formula | C16H14BrN5O4S.HCl |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 372196-77-5 |
| Synonyms | PIK75 |
| SMILES | CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)/N=C/C2=CN=C3N2C=C(C=C3)Br.Cl |
Description |
PIK-75 is an imidazopyridine that selectively inhibits p110α with an IC50 value of 5.8 nM.2 It inhibits p110γ and p110β considerably less effectively with IC50 values of 0.076 µM and 1.3 µM, respectively. | ||||||||||
Targets |
|
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| Solubility (25°C)* | In vitro | DMSO | 3 mg/mL (6.13 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.46 mL | 102.31 mL | 204.62mL |
| 0.5 mM | 4.09 mL | 20.46 mL | 40.92 mL |
| 1 mM | 2.05 mL | 10.23 mL | 20.46 mL |
| 5 mM | 0.41 mL | 2.05 mL | 4.09 mL |
*The above data is based on the productmolecular weight 488.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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