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$0.00 - Pridham KJ, .et al. PIK3CB/p110β is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844
Biological Activity
PIK-75 is an imidazopyridine that selectively inhibits p110α with an IC50 value of 5.8 nM.2 It inhibits p110γ and p110β considerably less effectively with IC50 values of 0.076 µM and 1.3 µM, respectively.
Targets
| DNA-PK (Cell-free assay) | p110α (Cell-free assay) | p110γ (Cell-free assay) | p110δ (Cell-free assay) | p110β (Cell-free assay) |
| 2 nM | 5.8 nM | 76 nM | 0.51 μM | 1.3 μM |
| In vitro | DMSO | Warmed: 4 mg/mL (8.18 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.46 mL | 102.31 mL | 204.62 mL |
| 0.5 mM | 4.09 mL | 20.46 mL | 40.92 mL |
| 1 mM | 2.05 mL | 10.23 mL | 20.46 mL |
| 5 mM | 0.41 mL | 2.05 mL | 4.09 mL |
*The above data is based on the productmolecular weight 488.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10729 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 372196-77-5 |
| Formula | C16H14BrN5O4S.HCl |
| M. Wt | 488.7 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | PIK75 |
| SMILES | CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)/N=C/C2=CN=C3N2C=C(C=C3)Br.Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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