Vasopressin Receptor

Cat. No.

A64035

CAS No.

32215-99-9

[Lys8] Vasopressin Desglycinamide

[Lys8] Vasopressin Desglycinamide is a vasopressin analog that primarily targets vasopressin receptors to exert its effects. This compound plays a significant role in promoting memory consolidation and is utilized in research focusing on active and passive avoidance behaviors. Its ability to modulate cognitive functions makes it a valuable tool for studies investigating the mechanisms of memory and learning.

Cat. No.

A64036

CAS No.

1056550-56-1

V1b Receptor antagonist-1

V1b Receptor Antagonist-1 is a selective antagonist targeting the vasopressin 1b (V1b) receptor. This compound demonstrates significant antidepressant activity and is applicable in research focused on neurological disorders, particularly depression. Its ability to penetrate the blood-brain barrier enhances its suitability for studies investigating the role of V1b receptor modulation in therapeutic interventions for mood disorders.

Cat. No.

A64037

CAS No.

2296801-25-5

Elsovaptan

Elsovaptan is a selective vasopressin receptor antagonist that disrupts the action of vasopressin at its receptors, demonstrating potential in modulating fluid balance and blood pressure. This compound is primarily utilized in research related to neurodegenerative disorders, particularly Alzheimer’s disease. Through its mechanism, Elsovaptan may aid in elucidating the role of vasopressin signaling in cognitive decline and related pathologies.

Cat. No.

A64039

CAS No.

1622294-25-0

ML389

ML389 is a highly selective V1a receptor antagonist, displaying an IC50 value of 40 nM. This compound demonstrates significant potential in the research of central nervous system disorders, including anxiety, depression, and post-traumatic stress disorder (PTSD). Its ability to effectively inhibit the V1a receptor may contribute to advanced studies in neuropharmacology and therapeutic targeting.

Cat. No.

A64041

CAS No.

64158-84-5

[Deamino-Pen1,Val4,D-Arg8]-vasopressin

[Deamino-Pen1,Val4,D-Arg8]-vasopressin is a selective arginine-vasopressin (AVP) antagonist. This compound has been shown to significantly reduce plasma aldosterone concentrations in rat models. It serves as a valuable tool for investigating the growth and steroidogenic activity of the adrenal zona glomerulosa in rats.

Cat. No.

A64042

CAS No.

1021701-88-1

Val9-Oxytocin

Val9-Oxytocin is a selective antagonist of the vasopressin V1a receptor. This compound is a synthetic analog of oxytocin, with a substitution of valine for glycine at position 9. Val9-Oxytocin exhibits key biological activity in modulating V1a receptor signaling pathways, making it valuable for research applications related to cardiovascular, neuroendocrine, and behavioral studies.

Cat. No.

A64043

CAS No.

136105-89-0

Desamino(D-3-(3′-pyridyl)-Ala2,Arg8)-Vasopressin

Desamino(D-3-(3′-pyridyl)-Ala2,Arg8)-Vasopressin is a synthetic analog of vasopressin that primarily acts as an agonist at vasopressin receptors. While it exhibits moderate activity at antidiuretic receptors, it demonstrates potent agonistic effects on pituitary corticotrope receptors, making it a valuable tool for studying stress responses and adrenal gland function. This compound is suitable for research applications involving endocrine signaling and neuropeptide interactions.

Cat. No.

A64044

CAS No.

25255-33-8

[8-L-arginine] deaminovasopressin

Synonyms: dAVP

[8-L-arginine] deaminovasopressin (dAVP) is a synthetic analog of vasopressin, specifically targeting vasopressin receptors. This compound exhibits antidiuretic properties and showcases enhanced activity in modulating water reabsorption in renal tissues. dAVP is widely used in research related to fluid balance, electrolyte regulation, and various pathophysiological conditions associated with vasopressin-related signaling.

Cat. No.

A64046

CAS No.

210101-16-9

Conivaptan

Synonyms: YM 087 free base

Conivaptan is a dual antagonist of the vasopressin V1A and V2 receptors. It has been shown to improve outcomes in congestive heart failure by ameliorating fluid retention and enhancing cardiac systolic function. This compound is valuable in research applications related to cardiovascular physiology and the modulation of water homeostasis.

Cat. No.

A64047

CAS No.

176714-12-8

(d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin

Synonyms: d(CH2)5[Tyr(Me)2, Dab5]AVP

(d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin is a selective antagonist of the vasopressin V1a receptor, exhibiting a pA2 value of 6.71. This compound is instrumental in studying vasopressin's role in various physiological processes and pathophysiological conditions. Its specificity makes it a valuable tool for research related to vascular regulation, fluid balance, and associated disorders.

Cat. No.

A64050

CAS No.

331947-66-1

(R)-(+)-Tolvaptan

Synonyms: (R)-(+)-OPC-41061

(R)-(+)-Tolvaptan is the (R)-(+) enantiomer of the vasopressin receptor 2 (V2R) antagonist Tolvaptan. This compound exhibits selective and competitive inhibition of V2R, making it valuable for exploring the role of vasopressin in kidney function and fluid balance. It is widely used in research related to renal pathophysiology, particularly in the study of conditions such as heart failure and polycystic kidney disease.

Cat. No.

A64051

CAS No.

926035-36-1

DM-4111

DM-4111 is a potent inhibitor of the vasopressin V2 receptor, playing a significant role in modulating water reabsorption in the renal tubules. By inhibiting this receptor, DM-4111 facilitates the excretion of electrolyte-free water, making it valuable in studies related to fluid management in various physiological and pathological states. Its application extends to research focused on cardiovascular diseases, where regulation of fluid balance is critical.

Cat. No.

A64053

CAS No.

1520893-08-6

TASP0434299

TASP0434299 is a radiolabeled ligand targeting the vasopressin V1b receptor. It demonstrates high binding affinity for human and murine V1B receptors, with IC50 values of 0.526 nM and 0.641 nM, respectively, and exhibits potent antagonistic activity at the human V1B receptor with an IC50 of 0.639 nM. TASP0434299 acts as a substrate for human and rhesus monkey P-glycoprotein, leading to low brain uptake. Additionally, it binds specifically and saturably to V1B receptors in rat and monkey pituitary tissues, making it suitable for in vivo and in vitro studies. When radiolabeled, it serves as an effective V1B receptor radiotracer for visualization in positron emission tomography.

Cat. No.

A74045

CAS No.

37552-33-3

[Deglycinamide9, Arginine8]-Vasopressin

[Deglycinamide9, Arginine8]-Vasopressin is a synthetic analog of vasopressin, primarily targeting vasopressin receptors. This compound has been shown to induce platelet aggregation, contributing to its hemostatic effects. It is of interest in research applications related to hemostasis and coagulation processes.

Cat. No.

B10886

CAS No.

1426174-49-3

[Pmp1,DTyr(OEt)2,Val4,Cit8] Vasopressin

[Pmp1,DTyr(OEt)2,Val4,Cit8] Vasopressin is a synthetic analogue of the natural hormone vasopressin. This compound targets vasopressin receptors, influencing water retention and blood pressure regulation. Its unique structure lends itself to research applications in studying renal physiology and cardiovascular regulation, as well as exploring therapeutic potential in treating conditions like diabetes insipidus and hypotension.