CDK

Cat. No.

A12989

CAS No.

1231929-97-7

Abemaciclib (LY2835219)

Synonyms: LY 2835219

abemaciclib (LY2835219) is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity.

Cat. No.

A14427

CAS No.

571190-30-2

Palbociclib (PD-0332991)

Synonyms: PD0332991

Palbociclib is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.

Cat. No.

A10701

CAS No.

827022-32-2

PD-0332991 HCl (Palbociclib HCl)

PD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.

Cat. No.

A11129

CAS No.

779353-01-4

Dinaciclib (SCH 727965)

Synonyms: SCH727965

Dinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor, selectively inhibiting CDK1, CDK2, CDK5 and CDK9 with IC50 values of 3, 1, 1 and 4 nM respectively.

Cat. No.

A11167

CAS No.

891494-63-6

SCH 900776 (MK-8776)

Synonyms: MK-8776

SCH900776 is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. It specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents.

Cat. No.

A11034

CAS No.

552325-73-2

A-674563

A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively.

Cat. No.

A10390

CAS No.

146426-40-6

Alvocidib (Flavopiridol)

Synonyms: HMR-1275; L868275; Flavopiridol

Flavopiridol (Alvocidib) is a cyclin-dependent kinase inhibitor under clinical development for the treatment of chronic lymphocytic leukemia.

Cat. No.

A10806

CAS No.

186692-46-6

Seliciclib (Roscovitine)

Synonyms: CYC202; Roscovitine

Roscovitine (Seliciclib) is a CDK inhibitor that preferentially inhibit multiple enzyme targets including CDK2, CDK7 and CDK9.

Cat. No.

A14437

CAS No.

872573-93-8

Ro 3306

Ro 3306 is an ATP-competitive, potent cyclin-dependent kinase (cdk) 1 inhibitor (Ki values are 35 and 110 nM for cdk1/cyclin B1 and cdk1/cyclin A respectively).

Cat. No.

A11164

CAS No.

845714-00-3

PHA-767491

PHA-767491 is a potent, ATP-competitive dual cdc7/cdk9 inhibitor (IC50 values are 10 and 34 nM respectively) that prevents initiation of DNA replication.

Cat. No.

A12742

CAS No.

1223498-69-8

Roniciclib (BAY 1000394)

Synonyms: BAY10-00394

BAY 1000394 is an orally bioavailable cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity.

Cat. No.

A13549

CAS No.

1211441-98-3

Ribociclib (LEE011)

Synonyms: LEE-011

LEE011 is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.

Cat. No.

A13677

CAS No.

1169562-71-3

BMS-863233 (XL-413)

Synonyms: BMS-863233; XL-413

BMS-863233, also known as XL-413, is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity.

Cat. No.

A10093

CAS No.

844442-38-2

AT7519

AT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation.

Cat. No.

A10494

CAS No.

443797-96-4

JNJ-7706621

JNJ-7706621 is pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays. It also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1.

Cat. No.

A10716

CAS No.

718630-59-2

PHA-793887

PHA-793887, a novel potent inhibitor of Cdk, target on kinds of cyclin-dependent kinase under low concentrations and poses high activity against several cancer cell lines.

Cat. No.

A11220

CAS No.

142273-20-9

Kenpaullone

Kenpaullone is a potent inhibitor of CDK inhibitor (IC50 values are 0.4, 0.68, 7.5, 0.85 µM for CDK1/cyclinB, CDK2/cyclinA, CDK2/cyclinE and CDK5/p25 respectively). Also inhibits GSK-3β and LCK (IC50 values are 0.23 and 0.47 µM respectively) Displays reduced activity for other kinases (IC50 values are 15, 20, 20, 9 µM for c-src, casein kinase 2, ERK1 and ERK2 respectively). Also Generates iPSCs. Displays antiproliferative properties.

Cat. No.

A12216

CAS No.

632-85-9

Wogonin

Wogonin is an anti-inflammatory agent and an inhibitor of CDK9 and does not inhibit CDK2, CDK4 and CDK6 at doses that inhibit CDK9 activity; Also inhibits N-acetyltransferase

Cat. No.

A13111

CAS No.

882531-87-5

R1530

R1530 is a pyrazolobenzodiazepine small molecule with potential antiangiogenesis and antineoplastic activities. R1530 is also a mitosis-angiogenesis inhibitor (MAI) that inhibits multiple receptor tyrosine kinases involved in angiogenesis, such as vascular endothelial growth factor receptor (VEGFR)-1, -2, -3, platelet-derived growth factor receptor (PDGFR) beta? FMS-like tyrosine kinase (Flt)-3, and fibroblast growth factor receptor (FGFR) -1, -2.

Cat. No.

A13811

CAS No.

827022-33-3

PD 0332991 Isethionate

Synonyms: PD0332991

PD 0332991 Isethionate is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM respectively.

Cat. No.

A14192

CAS No.

1604810-83-4

THZ1

Synonyms: THZ-1,THZ 1

THZ1 is a novel selective and potent covalent CDK7 inhibitor with IC50(binding affinity) of 3.2 nM; inhibits Jurkat cell's proliferation with IC50 of 50 nM

Cat. No.

A16386

CAS No.

1231930-82-7

LY2835219 methanesulfonate

Synonyms: Abemaciclib

LY2835219 is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively. Phase 3.

Cat. No.

A16810

CAS No.

1414943-88-6

Atuveciclib (BAY-1143572)

Synonyms: BAY 1143572

Atuveciclib, also known as BAY1143572, is a highly selective, potent and orally available inhibitor of PTEFb/CDK9 currently in Phase I.

Cat. No.

A16875

CAS No.

2185857-97-8

PF-06873600

PF-06873600 is an orally bioavailable, cyclin-dependent kinase (CDK) inhibitor, with potential antineoplastic activity.

Cat. No.

A22303

CAS No.

1211443-80-9

Ribociclib hydrochloride

Synonyms: LEE011 hydrochloride

Ribociclib hydrochloride (LEE011 hydrochloride) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively,