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Publications citing Adooq Products
PHA-767491 Citations (1)
- Qi Li, .et al. CDC7-dependent transcriptional regulation of RAD54L is essential for tumorigenicity and radio-resistance of glioblastoma, Transl Oncol, 2018, Apr; 11(2): 300–306 PMID: 29413763
Chemical Information
| Catalog Num | A11164 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 213.24 |
| Formula | C12H11N3O |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 845714-00-3 |
| Synonyms | PHA767491 |
| SMILES code | C1CNC(=O)C2=C1NC(=C2)C3=CC=NC=C3 |
| Chemical Name | 1,5,6,7-Tetrahydro-2-(4-pyridinyl)- 4H-pyrrolo[3,2-c]pyridin-4-one hydrochloride |
Description |
PHA-767491 is a potent, ATP-competitive dual cdc7/cdk9 inhibitor (IC50 values are 10 and 34 nM respectively) that prevents initiation of DNA replication. |
|||||
| Solubility (25°C) * | In vitro | DMSO | 24 mg/mL (112.54 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 1% DMSO/30% polyethylene glycol/1% Tween 80 | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 46.9 mL | 234.48 mL | 468.96mL |
| 0.5 mM | 9.38 mL | 46.9 mL | 93.79 mL |
| 1 mM | 4.69 mL | 23.45 mL | 46.9 mL |
| 5 mM | 0.94 mL | 4.69 mL | 9.38 mL |
*The above data is based on the productmolecular weight 213.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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