Catalog No.
Product Name
Application
Product Information
Citations
-
Ligand for E3 Ligase
CRBN ligand-449 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be effectively connected to a target protein ligand through a linker to create a PROTAC (proteolysis targeting chimera). CRBN ligand-449 is valuable for research into targeted protein degradation and the development of innovative therapeutics. -
Ligand for E3 Ligase
CRBN ligand-572 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound can be utilized to construct proteolysis-targeting chimeras (PROTACs) by linking it to target protein ligands through a suitable linker. CRBN ligand-572 is essential in studying protein degradation pathways and offers potential applications in targeted protein modulation for therapeutic research. -
Ligand for E3 Ligase
CRBN ligand-318 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of CRBN to specific target proteins. This compound serves as a pivotal component in the development of PROTACs (proteolysis-targeting chimeras), enabling targeted protein degradation in cellular systems. Its unique ability to engage with CRBN makes it a valuable tool for investigating ubiquitin-proteasome pathway mechanisms and exploring new therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-619 is a ligand targeting the E3 ubiquitin ligase cereblon (CRBN), facilitating its recruitment for protein degradation processes. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera) for effective modulation of protein levels. CRBN ligand-619 is valuable for research applications in protein homeostasis, targeted therapy development, and the investigation of ubiquitin-proteasome system dynamics. -
Ligand for E3 Ligase
CRBN ligand-751 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the cereblon protein. This compound can be utilized in the development of PROTACs (proteolysis-targeting chimeras) by linking it to a target protein ligand through a suitable linker. CRBN ligand-751 is valuable for research applications in targeted protein degradation and the exploration of ubiquitin-proteasome system mechanisms. -
Ligand for E3 Ligase
CRBN ligand-421 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. It can be utilized to construct proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through an appropriate linker. This compound is valuable for studies involving targeted protein degradation and the modulation of protein levels within cellular systems. -
Ligand for E3 Ligase
CRBN ligand-615 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), utilized to recruit the CRBN protein in targeted protein degradation applications. It can be integrated with a target protein ligand through a linker, facilitating the formation of a PROTAC (proteolysis-targeting chimera). This compound enables selective degradation of specific proteins, making it valuable for research in areas such as cancer biology and targeted therapeutics. -
E3 Ligase Ligand
E3 ligase Ligand 66 is an E3 ligase ligand designed to specifically recruit inhibitor of apoptosis (IAP) proteins. This compound facilitates targeted protein degradation through the formation of PROTACs when conjugated with ligands such as SARS-CoV-2 Mpro ligand 1, enabling researchers to manipulate protein levels in cellular systems. Its applications extend to investigations in degradation pathways and therapeutic strategies against diseases, including viral infections. -
Ligand for E3 Ligase
CRBN ligand-638 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN to target proteins, enabling targeted protein degradation through the formation of PROTACs (proteolysis-targeting chimeras). This compound is essential for studies focused on selective protein modulation and degradation pathways, contributing to advancements in therapeutic research and development. -
Ligand for E3 Ligase
CRBN ligand-422 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be effectively conjugated to target protein ligands through a linker to create PROTACs, enabling targeted protein degradation. CRBN ligand-422 is valuable in research applications focused on proteolysis-targeting chimeras and the modulation of specific protein levels within cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-454 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. Its unique structure allows for conjugation with a target protein ligand through a linker, enabling the formation of a PROTAC. This compound is vital for studies focused on targeted protein degradation and can significantly contribute to the development of novel therapeutic strategies in cancer and other diseases linked to protein homeostasis. -
Ligand for E3 Ligase
CRBN ligand-588 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of the cereblon protein in targeted protein degradation applications. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). Its use in research promotes advancements in the development of targeted therapies through the modulation of protein levels in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-643 is a ligand designed to target the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. It can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). This compound is valuable for research applications focusing on targeted protein degradation and the modulation of cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-540 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of the CRBN protein. This compound is pivotal for the construction of PROTACs by enabling the linkage of target protein ligands through a suitable spacer. Its utility extends to targeted protein degradation studies, contributing to the exploration of protein regulation and therapeutic interventions in various biological contexts. -
Ligand for E3 Ligase
Hydrouracil-(4-Br-2,6-difluorobenzene) serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated with target protein ligands through linkers to create PROTAC molecules, which are pivotal in targeted protein degradation research. Its application in the development of novel therapeutic strategies highlights its significance in chemical biology and drug discovery. -
Ligand for E3 Ligase
CRBN ligand-357 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of cereblon, enabling targeted protein degradation when conjugated with a proximal ligand through a linker. This compound is valuable for researchers studying protein homeostasis and developing PROTACs for applications in targeted cancer therapies and other signaling pathways. -
Ligand for E3 Ligase
CRBN ligand-336 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of the CRBN protein to target proteins, enabling the design of proteolysis-targeting chimeras (PROTACs). This compound is essential for studies focused on targeted protein degradation and can be utilized in various research applications involving protein manipulation and regulation. -
Ligand for E3 Ligase
CRBN ligand-261 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), which facilitates the recruitment of CRBN to target proteins. This compound can be utilized in the design of PROTACs (proteolysis-targeting chimeras) by linking it to a target protein ligand through a suitable linker. Its applications in chemical biology include targeted degradation of specific proteins, thereby advancing research in drug development and protein homeostasis. -
Ligand for E3 Ligase
CRBN ligand-548 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized to form proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand via a suitable linker. Its application in targeted protein degradation research makes it a valuable tool for studying protein homeostasis and therapeutic interventions. -
Ligand for E3 Ligase
Hydrouracil-(4-CP) is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN in targeted protein degradation applications. This compound can be conjugated to a specific target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimeras). Hydrouracil-(4-CP) is instrumental in studies focusing on selective protein degradation and cellular protein turnover. -
Ligand for E3 Ligase
CRBN ligand-497 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be coupled with a ligand for a target protein through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). CRBN ligand-497 is utilized in research to explore targeted protein degradation pathways and to study the role of the ubiquitin-proteasome system in cellular regulation. -
Ligand for E3 Ligase
CRBN ligand-605 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound effectively recruits the cereblon protein, facilitating the formation of PROTAC molecules when linked to target protein ligands. CRBN ligand-605 is primarily utilized in studies involving targeted protein degradation, enabling researchers to explore therapeutic applications in cancer and other diseases. -
Ligand for E3 Ligase
CRBN ligand-529 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). CRBN ligand-529 is essential for studies involving targeted protein degradation and the investigation of cellular pathways influenced by ubiquitin-mediated proteolysis. -
Ligand for E3 Ligase
CRBN ligand-293 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be coupled with a target protein ligand through a linker to create a proteolysis targeting chimera (PROTAC). CRBN ligand-293 is essential for research applications aimed at studying targeted protein degradation and modulating cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-602 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein to target substrates. This compound can be utilized in the development of PROTACs (proteolysis-targeting chimeras) by linking it to a target protein ligand through a suitable linker. Its utility in targeted protein degradation makes it a valuable tool for researchers interested in modulating protein levels in cellular systems. -
Ligand for E3 Ligase
CRBN ligand-758 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized to link target protein ligands through a suitable linker, enabling the formation of PROTACs (proteolysis targeting chimeras). CRBN ligand-758 offers significant potential for applications in targeted protein degradation research and the development of novel therapeutic strategies. -
Ligand for E3 Ligase
CRBN Ligand-456 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. It is designed for use in the development of PROTACs by linking to target protein ligands through a suitable linker. This compound plays a crucial role in studying protein degradation pathways and offers potential in therapeutic applications involving targeted protein modulation. -
Ligand for E3 Ligase
CRBN ligand-442 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to target protein ligands through a linker to create a proteolysis-targeting chimera (PROTAC). Its application in targeted protein degradation makes it valuable for studying protein dynamics and potential therapeutic interventions. -
Pomalidomide Derivative
Pomalidomide-COCH2Cl is a derivative of Pomalidomide featuring a chloroacetamide group on the benzyl ring. This compound functions by inhibiting immunomodulatory effects and has shown promise in the treatment of various cancers and hematological disorders. It is particularly valuable for research into the modulation of immune responses and the exploration of novel therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-624 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of the cereblon protein. This molecule can be conjugated to a target protein ligand through a linker, thereby enabling the formation of a PROTAC (proteolysis-targeting chimera). Its utility in targeted protein degradation makes it a valuable tool in research applications aimed at modulating protein levels within cellular systems. -
Ligand for E3 Ligase
CRBN ligand-321 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. It can be conjugated to a target protein ligand through a linker to generate a proteolysis-targeting chimera (PROTAC). This compound is valuable for investigating ubiquitin-proteasome system modulation and identifying novel therapeutic strategies in target protein degradation research. -
Ligand for E3 Ligase
CRBN ligand-706 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN to target proteins, enabling the development of proteolysis-targeting chimeras (PROTACs). CRBN ligand-706 serves as a valuable tool in research focused on targeted protein degradation and cellular regulation pathways. -
Ligand for E3 Ligase
CRBN ligand-507 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of the cereblon protein, making it a valuable tool in targeted protein degradation research. CRBN ligand-507 can be conjugated to a target-specific ligand through a linker, enabling the creation of PROTACs for the selective degradation of intracellular proteins. Its applications include studying protein turnover and modulation of cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-607 is an E3 ubiquitin ligase cereblon (CRBN) ligand that effectively recruits the CRBN protein. This compound can be utilized to link a target protein ligand through a linker, facilitating the development of PROTACs (proteolysis-targeting chimeras). Its applications in molecular biology research include targeted protein degradation and the modulation of protein function, providing valuable insights into cellular processes. -
Ligand for E3 Ligase
CRBN ligand-255 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the targeted recruitment of CRBN to specific proteins. This compound enables the design of proteolysis-targeting chimeras (PROTACs) by linking it with target protein ligands through a suitable linker. CRBN ligand-255 is valuable for research into targeted protein degradation and the modulation of cellular pathways through ubiquitin-proteasome system engagement. -
Ligand for E3 Ligase
CRBN ligand-194 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimera). Its use in research enables the selective degradation of target proteins, making it a valuable tool for studying protein dynamics and therapeutic interventions in various diseases. -
Ligand for E3 Ligase
CRBN ligand-444 acts as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. It is designed for use in PROTAC (proteolysis-targeting chimeras) applications by enabling the linkage of a target protein ligand through a suitable linker. This compound is essential for studies involving targeted protein degradation and modulation of cellular processes associated with protein turnover. -
Ligand for E3 Ligase
CRBN ligand-697 is an effective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound is designed to facilitate the recruitment of the cereblon protein, enabling targeted protein degradation through the development of PROTACs (proteolysis-targeting chimeras). Its application in research allows for the modulation of protein levels, providing insights into cellular mechanisms and potential therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-489 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of CRBN to target proteins. This compound can be utilized in the development of PROTACs (Proteolysis Targeting Chimeras) by being linked to target protein ligands through a suitable linker. It serves as a valuable tool for research in targeted protein degradation and elucidating cellular protein regulation mechanisms. -
Ligand for E3 Ligase
CRBN ligand-337 is an E3 ubiquitin ligase ligand that specifically interacts with cereblon (CRBN). This compound facilitates the recruitment of CRBN, enabling the creation of proteolysis-targeting chimeras (PROTACs) when conjugated with a target protein ligand through a linker. CRBN ligand-337 is instrumental in drug discovery and research focused on targeted protein degradation pathways. -
Ligand for E3 Ligase
CRBN ligand-551 is an E3 ubiquitin ligase ligand that targets cereblon (CRBN) to facilitate protein degradation. It effectively recruits the CRBN protein, enabling the development of PROTACs (Proteolysis Targeting Chimeras) when linked to a target protein ligand through a suitable linker. This compound is useful in studies of targeted protein degradation and cellular regulation mechanisms. -
Ligand for E3 Ligase
CRBN ligand-542 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein in targeted protein degradation applications. This compound can be effectively connected to other target protein ligands through a linker, allowing for the formation of PROTACs (proteolysis-targeting chimeras). Its utility in biochemical research enhances the understanding of protein homeostasis and therapeutic approaches in various diseases. -
Ligand for E3 Ligase
CRBN ligand-272 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized in the design of proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through a suitable linker. Its application extends to the study of protein degradation pathways and the development of innovative therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-749 serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the targeted recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). Its primary applications include studying protein degradation pathways, and investigating the therapeutic potential of targeted protein modulation in various diseases. -
Ligand for E3 Ligase
Thalidomide-5-NH2-6-F is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound serves as an important tool in the development of PROTACs (proteolysis-targeting chimeras) by enabling the targeting and degradation of specific proteins, thereby providing valuable insights into protein homeostasis and disease mechanisms. Its application in chemical biology research makes it instrumental in studying ubiquitin-proteasome pathways and therapeutic modulation. -
Ligand for E3 Ligase
CRBN ligand-888 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). Its application in targeted protein degradation research offers significant potential for therapeutic interventions in various diseases. -
Ligand for E3 Ligase
CRBN ligand-452 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. It is designed for use in PROTAC (proteolysis-targeting chimera) development, allowing for targeted protein degradation by linking to a specific target protein ligand. This compound is valuable in research applications focused on modulating protein levels and studying cellular processes influenced by ubiquitination. -
Ligand for E3 Ligase
CRBN ligand-493 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with target protein ligands through a linker to generate a PROTAC (proteolysis-targeting chimera), enabling targeted protein degradation. Researchers can utilize CRBN ligand-493 in studies of protein regulation and degradation pathways, as well as in the development of novel therapeutic strategies involving targeted modulation of protein levels. -
Ligand for E3 Ligase
CRBN ligand-549 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), which facilitates the recruitment of CRBN to target proteins. This compound can be utilized in the design and synthesis of PROTACs (proteolysis-targeting chimeras), enabling targeted degradation of specific proteins within cellular pathways. Researchers can apply CRBN ligand-549 in studies aimed at understanding protein turnover, modulation of signaling pathways, and therapeutic development for various diseases. -
Ligand for E3 Ligase
CRBN ligand-729 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound can be utilized to connect with a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). CRBN ligand-729 is essential for research applications focused on targeted protein degradation and therapeutic development.
