Catalog No.
Product Name
Application
Product Information
Citations
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Pomalidomide Derivative
Pomalidomide-COCH2Cl is a derivative of Pomalidomide featuring a chloroacetamide group on the benzyl ring. This compound functions by inhibiting immunomodulatory effects and has shown promise in the treatment of various cancers and hematological disorders. It is particularly valuable for research into the modulation of immune responses and the exploration of novel therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-624 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of the cereblon protein. This molecule can be conjugated to a target protein ligand through a linker, thereby enabling the formation of a PROTAC (proteolysis-targeting chimera). Its utility in targeted protein degradation makes it a valuable tool in research applications aimed at modulating protein levels within cellular systems. -
Ligand for E3 Ligase
CRBN ligand-321 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. It can be conjugated to a target protein ligand through a linker to generate a proteolysis-targeting chimera (PROTAC). This compound is valuable for investigating ubiquitin-proteasome system modulation and identifying novel therapeutic strategies in target protein degradation research. -
Ligand for E3 Ligase
CRBN ligand-706 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN to target proteins, enabling the development of proteolysis-targeting chimeras (PROTACs). CRBN ligand-706 serves as a valuable tool in research focused on targeted protein degradation and cellular regulation pathways. -
Ligand for E3 Ligase
CRBN ligand-507 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of the cereblon protein, making it a valuable tool in targeted protein degradation research. CRBN ligand-507 can be conjugated to a target-specific ligand through a linker, enabling the creation of PROTACs for the selective degradation of intracellular proteins. Its applications include studying protein turnover and modulation of cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-607 is an E3 ubiquitin ligase cereblon (CRBN) ligand that effectively recruits the CRBN protein. This compound can be utilized to link a target protein ligand through a linker, facilitating the development of PROTACs (proteolysis-targeting chimeras). Its applications in molecular biology research include targeted protein degradation and the modulation of protein function, providing valuable insights into cellular processes. -
Ligand for E3 Ligase
CRBN ligand-255 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the targeted recruitment of CRBN to specific proteins. This compound enables the design of proteolysis-targeting chimeras (PROTACs) by linking it with target protein ligands through a suitable linker. CRBN ligand-255 is valuable for research into targeted protein degradation and the modulation of cellular pathways through ubiquitin-proteasome system engagement. -
Ligand for E3 Ligase
CRBN ligand-194 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimera). Its use in research enables the selective degradation of target proteins, making it a valuable tool for studying protein dynamics and therapeutic interventions in various diseases. -
Ligand for E3 Ligase
CRBN ligand-444 acts as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. It is designed for use in PROTAC (proteolysis-targeting chimeras) applications by enabling the linkage of a target protein ligand through a suitable linker. This compound is essential for studies involving targeted protein degradation and modulation of cellular processes associated with protein turnover. -
Ligand for E3 Ligase
CRBN ligand-697 is an effective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound is designed to facilitate the recruitment of the cereblon protein, enabling targeted protein degradation through the development of PROTACs (proteolysis-targeting chimeras). Its application in research allows for the modulation of protein levels, providing insights into cellular mechanisms and potential therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-489 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of CRBN to target proteins. This compound can be utilized in the development of PROTACs (Proteolysis Targeting Chimeras) by being linked to target protein ligands through a suitable linker. It serves as a valuable tool for research in targeted protein degradation and elucidating cellular protein regulation mechanisms. -
Ligand for E3 Ligase
CRBN ligand-337 is an E3 ubiquitin ligase ligand that specifically interacts with cereblon (CRBN). This compound facilitates the recruitment of CRBN, enabling the creation of proteolysis-targeting chimeras (PROTACs) when conjugated with a target protein ligand through a linker. CRBN ligand-337 is instrumental in drug discovery and research focused on targeted protein degradation pathways. -
Ligand for E3 Ligase
CRBN ligand-551 is an E3 ubiquitin ligase ligand that targets cereblon (CRBN) to facilitate protein degradation. It effectively recruits the CRBN protein, enabling the development of PROTACs (Proteolysis Targeting Chimeras) when linked to a target protein ligand through a suitable linker. This compound is useful in studies of targeted protein degradation and cellular regulation mechanisms. -
Ligand for E3 Ligase
CRBN ligand-542 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein in targeted protein degradation applications. This compound can be effectively connected to other target protein ligands through a linker, allowing for the formation of PROTACs (proteolysis-targeting chimeras). Its utility in biochemical research enhances the understanding of protein homeostasis and therapeutic approaches in various diseases. -
Ligand for E3 Ligase
CRBN ligand-272 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized in the design of proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through a suitable linker. Its application extends to the study of protein degradation pathways and the development of innovative therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-749 serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the targeted recruitment of the cereblon protein. This compound can be conjugated with a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). Its primary applications include studying protein degradation pathways, and investigating the therapeutic potential of targeted protein modulation in various diseases. -
Ligand for E3 Ligase
Thalidomide-5-NH2-6-F is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound serves as an important tool in the development of PROTACs (proteolysis-targeting chimeras) by enabling the targeting and degradation of specific proteins, thereby providing valuable insights into protein homeostasis and disease mechanisms. Its application in chemical biology research makes it instrumental in studying ubiquitin-proteasome pathways and therapeutic modulation. -
Ligand for E3 Ligase
CRBN ligand-888 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). Its application in targeted protein degradation research offers significant potential for therapeutic interventions in various diseases. -
Ligand for E3 Ligase
CRBN ligand-452 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. It is designed for use in PROTAC (proteolysis-targeting chimera) development, allowing for targeted protein degradation by linking to a specific target protein ligand. This compound is valuable in research applications focused on modulating protein levels and studying cellular processes influenced by ubiquitination. -
Ligand for E3 Ligase
CRBN ligand-493 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated with target protein ligands through a linker to generate a PROTAC (proteolysis-targeting chimera), enabling targeted protein degradation. Researchers can utilize CRBN ligand-493 in studies of protein regulation and degradation pathways, as well as in the development of novel therapeutic strategies involving targeted modulation of protein levels. -
Ligand for E3 Ligase
CRBN ligand-549 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), which facilitates the recruitment of CRBN to target proteins. This compound can be utilized in the design and synthesis of PROTACs (proteolysis-targeting chimeras), enabling targeted degradation of specific proteins within cellular pathways. Researchers can apply CRBN ligand-549 in studies aimed at understanding protein turnover, modulation of signaling pathways, and therapeutic development for various diseases. -
Ligand for E3 Ligase
CRBN ligand-729 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound can be utilized to connect with a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). CRBN ligand-729 is essential for research applications focused on targeted protein degradation and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-450 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of CRBN to target proteins. This compound can be effectively conjugated to a target protein ligand through a linker to generate a proteolysis-targeting chimera (PROTAC). Its application in targeted protein degradation research provides an innovative approach to modulating protein levels and studying cellular processes. -
Ligand for E3 Ligase
CRBN ligand-663 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), which facilitates the recruitment of the CRBN protein. This compound can be effectively utilized in the development of PROTACs by conjugating it to a target protein ligand through a suitable linker. It serves as an important tool for investigating targeted protein degradation and elucidating the biological roles of specific protein targets in cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-275 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound enables the synthesis of PROTACs (proteolysis-targeting chimeras) by linking to target protein ligands through a suitable linker. CRBN ligand-275 is a valuable tool for studies investigating targeted protein degradation and related therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-385 is an E3 ubiquitin ligase ligand that specifically targets cereblon (CRBN). This compound facilitates the recruitment of CRBN, enabling the formation of PROTACs when coupled with target protein ligands via a linker. CRBN ligand-385 is essential for studies involving targeted protein degradation and the exploration of novel therapeutic strategies in various diseases. -
Ligand for E3 Ligase
CRBN ligand-721 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a suitable linker, enabling the development of Proteolysis Targeting Chimeras (PROTACs). CRBN ligand-721 is valuable for research applications focused on targeted protein degradation and the modulation of cellular signaling pathways. -
Ligand for E3 Ligase
CRBN ligand-270 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of CRBN to target proteins. This compound can be conjugated to a ligand for a specific target protein through a linker, enabling the development of proteolysis-targeting chimeras (PROTACs). CRBN ligand-270 is valuable for research in targeted protein degradation and the modulation of protein levels in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-575 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target ligand through a linker, enabling the formation of PROTACs (Proteolysis Targeting Chimeras). The use of CRBN ligand-575 in research supports the investigation of protein degradation pathways and the development of targeted therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-349 is an effective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand using a linker, enabling the synthesis of proteolysis-targeting chimeras (PROTACs). It is valuable for research in targeted protein degradation and potential therapeutic applications in various disease models. -
Ligand for E3 Ligase
CRBN ligand-623 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of cereblon to target proteins, enabling the formation of PROTACs (proteolysis-targeting chimeras) when covalently linked to target protein ligands. CRBN ligand-623 is valuable for research applications focused on targeted protein degradation and the modulation of cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-381 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN in targeted protein degradation applications. This compound can be conjugated with a target protein ligand through a linker to form a proteolysis-targeting chimeric molecule (PROTAC). It serves as an important tool in chemical biology for studying protein degradation mechanisms and therapeutic applications. -
Ligand for E3 Ligase
CRBN ligand-665 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker, enabling the development of proteolysis-targeting chimeras (PROTACs). The application of CRBN ligand-665 is significant in studying targeted protein degradation and in the development of innovative therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-334 serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be effectively conjugated to a target protein ligand through a linker, enabling the formation of PROTACs (proteolysis-targeting chimeras). Researchers can utilize CRBN ligand-334 in studies aimed at targeted protein degradation and the modulation of cellular pathways. -
Ligands for E3 Ligase
CRBN ligand-183 is a ligand for the CRBN-type E3 ubiquitin ligase, facilitating the development of PROTACs (proteolysis-targeting chimeras). This compound enables targeted protein degradation by harnessing the cellular ubiquitin-proteasome system. It is a valuable tool for research applications in drug discovery and development, particularly in understanding protein function and regulation. -
Ligand for E3 Ligase
CRBN ligand-313 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is designed to be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). CRBN ligand-313 serves as a valuable tool for studying targeted protein degradation and its applications in drug discovery and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-301 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized to conjugate with target protein ligands through a linker, enabling the formation of proteolysis-targeting chimeras (PROTACs). Its application in research enables the study of targeted protein degradation pathways, expanding the potential for therapeutic development in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-708 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of CRBN to specific target proteins. This compound can be utilized to construct proteolysis-targeting chimeras (PROTACs) by linking it with a target protein ligand through a suitable linker. CRBN ligand-708 is valuable for studying targeted protein degradation and exploring potential therapeutic applications in various diseases. -
Ligand for E3 Ligase
CRBN ligand-233 acts as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis-targeting chimera). It is utilized in research to explore targeted protein degradation pathways and develop novel therapeutic strategies in various disease models. -
Ligand for E3 Ligase
CRBN ligand-709 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the targeted recruitment of this protein. It serves as a valuable tool for the development of proteolysis-targeting chimeras (PROTACs) by facilitating the linkage of a target protein ligand through a suitable linker. This compound is instrumental in studying protein degradation pathways and advancing targeted protein degradation research. -
Ligand for E3 Ligase
CRBN ligand-441 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein for targeted protein degradation applications. By connecting CRBN ligand-441 to a target protein ligand through a linker, it can be utilized to create a PROTAC (proteolysis-targeting chimera), thereby enabling selective modulation of protein levels in cellular processes. This compound is valuable in the study of protein dynamics and therapeutic development in various diseases. -
Ligand for E3 Ligase
CRBN ligand-483 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be conjugated to a specific target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis targeting chimera) for targeted protein degradation studies. It serves as a valuable tool in the exploration of protein turnover and disease mechanisms related to ubiquitination pathways. -
Ligand for E3 Ligase
CRBN ligand-420 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the CRBN protein. This compound is designed for use in the development of proteolysis-targeting chimeras (PROTACs), enabling targeted degradation of specific proteins through the ubiquitin-proteasome system. CRBN ligand-420 is valuable for applications in drug discovery and protein regulation studies. -
Ligands for E3 Ligase
CRBN ligand-110 serves as a selective ligand for the CRBN E3 ubiquitin ligase, facilitating the development of PROTAC (Proteolysis Targeting Chimeras). Its integration into PROTAC designs allows for targeted degradation of specific proteins, making it a valuable tool in drug discovery and therapeutic research. This compound is instrumental in exploring novel approaches to modulate protein levels and activity in cellular systems. -
Ligand for E3 Ligase
CRBN ligand-514 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker, allowing the formation of a PROTAC (proteolysis-targeting chimeras). CRBN ligand-514 is instrumental in the study of targeted protein degradation and therapeutic applications in cancer and other diseases. -
Ligand for E3 Ligase
CRBN ligand-573 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein to target proteins. This compound can be conjugated with a target protein ligand using a linker to create a PROTAC (proteolysis-targeting chimera), enabling selective degradation of specific proteins. CRBN ligand-573 is valuable for research in targeted protein degradation and cellular regulation studies. -
Ligands for E3 Ligase
CRBN ligand-63 is a ligand for the CRBN-type E3 ubiquitin ligase, functioning as a key component in the development of PROTAC (proteolysis-targeting chimeras). This compound facilitates targeted protein degradation by harnessing the cellular ubiquitin-proteasome system, offering valuable utility in research focused on protein regulation and therapeutic interventions. Its application extends to the study of cellular pathways and the modulation of protein levels in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-300 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be effectively conjugated to a target protein ligand using a linker to generate a Proteolysis Targeting Chimera (PROTAC). Its application is significant in studies focused on targeted protein degradation and pharmacological interventions in various biological systems. -
Ligand for E3 Ligase
CRBN ligand-276 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound serves as a critical component for the development of PROTACs (Proteolysis Targeting Chimeras), which are utilized to promote targeted protein degradation. Its applications are particularly relevant in studies focusing on protein regulation and cellular signaling pathways in various diseases. -
Ligand for E3 Ligase
CRBN ligand-707 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be effectively utilized to create proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through a suitable linker. Its applications are vital in research related to targeted protein degradation and the modulation of cellular pathways governed by ubiquitin-proteasome system.
