Monoamine Transporter

Cat. No.

A67466

CAS No.

63199-74-6

2-(tert-Butylamino)-1-phenylpropan-1-one hydrochloride

2-(tert-Butylamino)-1-phenylpropan-1-one hydrochloride is a non-selective agonist of monoamine transporters, specifically targeting dopamine (DAT), norepinephrine (NET), and serotonin (SERT). This compound exhibits significant activity in modulating monoamine neurotransmission, making it a valuable tool for investigating the biochemistry underlying depressive disorders. It serves as a useful reagent in pharmacological studies aimed at understanding the mechanisms of mood regulation and potential therapeutic approaches.

Cat. No.

A67467

CAS No.

178765-49-6

13-Hydroxyisobakuchiol

Synonyms: Delta3,2-Hydroxylbakuchiol

13-Hydroxyisobakuchiol is a selective inhibitor of monoamine transporters, primarily targeting the dopamine transporter (DAT) and norepinephrine transporter (NET) with IC50 values of 0.58 μM and 0.69 μM, respectively. In contrast, it exhibits significantly lower affinity for the serotonin transporter (SERT), with an IC50 of 312.02 μM. This compound is valuable for research applications related to neurodegenerative diseases, including Parkinson's disease, and mood disorders such as depression.

Cat. No.

A67468

CAS No.

1034048-49-1

Cendifensine

Cendifensine is a monoamine transporter inhibitor that targets the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT). It is known for its ability to inhibit the reuptake of these key neurotransmitters, thus enhancing their availability in the synaptic cleft. This compound is primarily utilized in research to study the mechanisms of mood disorders, depression, and other neurological conditions, making it a valuable tool for neuroscientific investigations.

Cat. No.

A67470

CAS No.

862377-27-3

(2S,3S,11bR)-Dihydrotetrabenazine

Synonyms: (2S,3S,11bR)-DHTBZ

(2S,3S,11bR)-Dihydrotetrabenazine is a selective inhibitor of the vesicular monoamine transporter 2 (VMAT2), exhibiting a Ki value of 593 nM. This compound disrupts the vesicular transport of monoamine neurotransmitters, including dopamine and serotonin, leading to decreased synaptic release of these neurotransmitters. (2S,3S,11bR)-Dihydrotetrabenazine is valuable for research into Huntington's chorea and other hyperkinetic disorders, providing insights into potential therapeutic strategies.

Cat. No.

A67472

CAS No.

28289-30-7

4-Methyl-α-ethyltryptamine

4-Methyl-α-ethyltryptamine functions primarily as a monoamine transporter modulator. This compound is known to influence the release and re-uptake of monoamines within the brain, making it potentially valuable for research into neurochemical pathways. Its structural similarities to α-Ethyltryptamine suggest its utility in studying the effects of tryptamine derivatives on neurotransmitter dynamics and behavior.

Cat. No.

A67473

CAS No.

1436695-49-6

VMAT2-IN-4

VMAT2-IN-4 is a selective inhibitor of the vesicular monoamine transporter-2 (VMAT2), demonstrating an affinity with a Ki value of 560 nM for [3H]-DTBZ binding and a more potent inhibition of [3H]-DA uptake into vesicles at a Ki of 45 nM. This compound effectively disrupts monoamine neurotransmitter packaging within vesicles, making it a valuable tool for investigating the mechanisms underlying methamphetamine addiction. VMAT2-IN-4 supports research into the modulation of dopaminergic signaling and its implications in addiction studies.

Cat. No.

A67474

CAS No.

2596358-28-8

FFN511 hydrochloride

FFN511 hydrochloride is a potent fluorescent false neurotransmitter (FFN) that selectively targets the vesicular monoamine transporter 2 (VMAT2). With an IC50 of 1 µM, it effectively inhibits serotonin binding to VMAT2-containing membranes. This compound enables real-time imaging of neurotransmitter release dynamics during exocytosis and is particularly useful for labeling dopamine terminals in live cortical-striatal acute slices, making it a valuable tool for studying synaptic transmission and neuropharmacology.

Cat. No.

A67475

CAS No.

2141974-01-6

GZ-11608

GZ-11608 is a potent and selective inhibitor of the vesicular monoamine transporter-2 (VMAT2) with a high affinity (Ki = 25 nM). This compound effectively reduces methamphetamine-induced dopamine release from isolated synaptic vesicles of dopaminergic neurons. Furthermore, GZ-11608 demonstrates rapid penetration into the brain and is characterized by an absence of neurotoxicity. It is a valuable tool for studying methamphetamine use disorder in therapeutic research.

Cat. No.

A67476

CAS No.

1210708-61-4

3-Bromoamphetamine hydrochloride

3-Bromoamphetamine hydrochloride is a para-substituted amphetamine that functions as a monoamine releasing agent, primarily targeting the monoamine transporters. This compound has been shown to facilitate the release of neurotransmitters such as serotonin, dopamine, and norepinephrine, making it valuable in studies of neuropharmacology and behavior. Its applications in research include investigations of mood disorders, stimulant effects, and the underlying mechanisms of psychoactive substances.

Cat. No.

A70509

CAS No.

14171-70-1

Trimipramine N-oxide

Trimipramine N-oxide is the active metabolite of the tricyclic antidepressant trimipramine, primarily targeting human monoamine transporters. It effectively inhibits noradrenaline (hNAT), serotonin (hSERT), and dopamine (hDAT) transporters, along with human organic cation transporters (hOCT1 and hOCT2), with IC50 values of 11.7, 3.59, 9.4, 9.35, and 27.4 nM, respectively. This compound is valuable for research focused on depression and anxiety, contributing to the understanding of mood disorders and the pharmacological mechanisms of antidepressants.

Cat. No.

A78892

CAS No.

202646-03-5

AHN 1-055 hydrochloride

Synonyms: 3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride

AHN 1-055 hydrochloride is a potent inhibitor of dopamine uptake, demonstrating an IC50 of 71 nM. This compound effectively binds to the dopamine transporter (DAT) and is capable of crossing the blood-brain barrier. Its ability to modulate dopamine levels makes it a valuable tool for research in neuropharmacology and the study of dopamine-related disorders.

Cat. No.

A78898

CAS No.

96850-13-4

Indatraline hydrochloride

Synonyms: Lu 19-005

Indatraline hydrochloride is a non-selective monoamine transporter inhibitor, primarily targeting the reuptake of dopamine, serotonin, and norepinephrine. This compound is relevant for research focused on antidepressant mechanisms. Additionally, Indatraline hydrochloride induces autophagy and inhibits cell proliferation, suggesting potential applications in the study of autophagy-related diseases, including atherosclerosis and restenosis.

Cat. No.

A78920

CAS No.

14008-79-8

3-CPMT

Synonyms: Tropine 4-chlorobenzhydryl ether hydrochloride

3-CPMT (Tropine 4-chlorobenzhydryl ether hydrochloride) is a potent inhibitor of dopamine uptake, interfering with dopamine reabsorption in neurons. This compound exhibits significant antihistaminic activity, contributing to its potential use in neuropharmacological research. It serves as a valuable tool for studying the role of dopamine in various physiological processes and may offer insights into the treatment of disorders associated with dopamine dysregulation.

Cat. No.

A78923

CAS No.

24558-01-8

Levophacetoperane

Synonyms: Phacetoperane free base

Levophacetoperane is a competitive inhibitor of norepinephrine and dopamine uptake. This compound demonstrates significant biological activity by modulating neurotransmitter levels, which can influence mood, cognition, and behavior. It is primarily utilized in research related to neurological disorders and studies examining the dopaminergic and noradrenergic systems.

Cat. No.

A79045

CAS No.

171655-92-8

Brasofensine sulfate

Synonyms: BMS-204756 sulfate

Brasofensine sulfate is a potent monoamine reuptake blocker, primarily functioning as a dopamine transporter antagonist. It is effective in modulating dopamine levels and has significant implications for research related to neurodegenerative diseases such as Parkinson's disease. This compound is valuable for studying dopaminergic system alterations and developing therapeutic strategies targeting dopamine reuptake.

Cat. No.

A79114

CAS No.

173830-14-3

Brasofensine maleate

Synonyms: BMS-204756 maleate

Brasofensine maleate is a selective monoamine reuptake blocker, primarily acting as a dopamine transporter antagonist. This compound demonstrates the ability to enhance dopaminergic signaling, making it relevant for research in Parkinson's disease and other neurodegenerative disorders. Its oral bioavailability supports in vivo studies aimed at exploring therapeutic strategies for dopamine-related pathologies.

Cat. No.

A79115

CAS No.

171655-91-7

Brasofensine

Synonyms: BMS-204756

Brasofensine is a potent oral-active dopamine transporter antagonist. Its primary mechanism involves blocking the reuptake of monoamines, which enhances dopaminergic signaling. This compound is primarily utilized in research related to Parkinson's disease, contributing to studies focused on dopaminergic dysfunction and potential therapeutic strategies.

Cat. No.

A79235

CAS No.

71827-56-0

Clemeprol

Synonyms: BRL 14342

Clemeprol is an orally active noradrenaline and 5-HT uptake blocker. It effectively inhibits the depletion of brain noradrenaline induced by 6-Hydroxydopamine and demonstrates a dose-dependent inhibition of reserpine-induced hypothermia. Clemeprol is applicable in the investigation of depression and related neurochemical pathways.

Cat. No.

A91502

CAS No.

15180-02-6

Amfonelic acid

Synonyms: WIN-25978

Amfonelic acid is a selective dopamine reuptake inhibitor that primarily targets the dopamine transporter. This compound exhibits significant activity by interfering with neuronal uptake of norepinephrine in the rat iris, while not affecting total norepinephrine or dopamine levels in the mouse brain. Amfonelic acid serves as a valuable pharmacological tool for investigating the brain reward system, the dopamine signaling pathway, and the functional role of dopamine transporters in various research applications.

Cat. No.

A92949

CAS No.

937245-42-6

Florbenazine

Synonyms: AV-133

Florbenazine is a diagnostic imaging agent that selectively targets the vesicular monoamine transporter 2 (VMAT2) in the central nervous system. The fluorine-18 labeled derivative is utilized in positron emission tomography (PET) scanning to assess neuromodulatory functions. Research has demonstrated a significant biodistribution profile in mice, with a high striatum-to-cerebellum ratio, supporting its application in the diagnostic investigation of neurodegenerative disorders, such as dementia with Lewy bodies and Parkinson’s disease.

Cat. No.

A94070

CAS No.

5700-94-7

Bishomoreserpine

Synonyms: Reserpic acid

Bishomoreserpine is a reserpine analog that acts primarily as a monoamine transporter inhibitor. It exhibits significant inhibitory activity, impacting neurotransmitter uptake and revealing potential roles in studying neuropharmacology. This compound is useful in research aimed at understanding the mechanisms of neurotransmitter regulation and developing therapeutic strategies for related disorders.

Cat. No.

A94319

CAS No.

2748622-76-4

α-Dimethylaminopentiophenone hydrochloride

Synonyms: Dimethylpentedrone hydrochloride

α-Dimethylaminopentiophenone hydrochloride is an analog of α-Pyrrolidinopentiophenone (α-PVP), characterized by the substitution of a dimethylamino group in place of the pyrrolidine moiety. This compound exhibits stimulant properties and has been used in research to investigate its effects on monoamine transporters, contributing to the understanding of its neuropharmacological profile. Its utility in exploring mechanisms underlying addiction and substance use disorders makes it a valuable tool for scientific studies in pharmacology and toxicology.

Cat. No.

A95132

CAS No.

1227293-15-3

N-Acetyl-3,4-MDMC

N-Acetyl-3,4-MDMC is a drug derivative structurally related to 3,4-methylenedioxymethcathinone. This compound has been investigated for its psychoactive properties and potential interactions with monoamine transporters, particularly serotonin and dopamine receptors. Research applications include studies on its effects on neural activity and behavioral responses in various models of neurotransmission.

Cat. No.

A95137

CAS No.

21005-63-0

6-(2-Aminopropyl)indole

6-(2-Aminopropyl)indole is a compound that acts as a monoamine releasing agent, primarily targeting the dopamine and norepinephrine transporters. It exhibits stimulant properties, making it relevant for studies focused on neuropharmacology and the behavioral effects of amphetamines. This reagent is suitable for research applications involving the examination of psychostimulant mechanisms and the exploration of potential therapeutic avenues for attention disorders.

Cat. No.

A95225

CAS No.

676487-42-6

3-BMC hydrochloride

3-Bromomethcathinone hydrochloride is a drug derivative targeting monoamine transporters. It exhibits stimulant properties and has been studied for its effects on catecholamine and serotonin release. This compound is utilized in research related to neuropharmacology and the exploration of synthetic cathinones.