Monoamine Transporter

Cat. No.

A58648

CAS No.

39022-39-4

Oxaprotiline hydrochloride

Synonyms: (Rac)-Levoprotiline hydrochloride

Oxaprotiline hydrochloride is a potent norepinephrine uptake inhibitor, primarily targeting the norepinephrine transport system. This compound exhibits significant antidepressant activity, making it valuable in the investigation of mood disorders and related therapeutic applications. Oxaprotiline hydrochloride is widely utilized in preclinical studies to explore its potential effects on neurotransmitter modulation and its implications in mental health research.

Cat. No.

A58792

CAS No.

60662-16-0

Binodaline

Synonyms: Binedaline

Binodaline is a selective norepinephrine reuptake inhibitor, exhibiting a Ki value of 25 nM. This compound is valuable for studying depressive disorders and can aid in the exploration of mechanisms underlying norepinephrine dysregulation in neuropsychiatric conditions. Its role in modulating norepinephrine levels makes it a useful tool in research focused on the treatment of mood disorders.

Cat. No.

A60041

CAS No.

1639208-51-7

Valbenazine dihydrochloride

Synonyms: NBI-98854 dihydrochloride

Valbenazine dihydrochloride is a selective inhibitor of the vesicular monoamine transporter 2 (VMAT2) and primarily targets dopamine receptors. It is utilized in the treatment of tardive dyskinesia, offering therapeutic benefits for alleviating movement disorder symptoms linked to chronic dopamine receptor antagonism. Extensive preclinical studies support its efficacy, particularly in relation to the genetic factors contributing to tardive dyskinesia.

Cat. No.

A60161

CAS No.

67469-45-8

GBR-12879 dihydrochloride

GBR-12879 dihydrochloride is a potent dopamine uptake inhibitor that selectively targets the dopamine transporter. Its primary mechanism involves preventing the reabsorption of dopamine, thus enhancing dopaminergic signaling. This compound is widely utilized in research to investigate the role of dopamine in neurological disorders and to explore potential therapeutic strategies for conditions such as depression and schizophrenia.

Cat. No.

A67402

CAS No.

3038464-68-2

NMDAR antagonist 5

NMDAR antagonist 5 (Compound A17) is a selective antagonist targeting the N-methyl-D-aspartate receptor (NMDAR) with an IC50 of 0.3 µM. This compound also inhibits monoamine transporters, including the serotonin transporter (SERT, IC50 = 1.1 µM), dopamine transporter (DAT, IC50 = 0.7 µM), and norepinephrine transporter (NET, IC50 = 2.7 µM). With a favorable safety profile and low toxicity across multiple organ systems, NMDAR antagonist 5 demonstrates potential antidepressant effects, making it a valuable tool for research into depression and related neurological disorders.

Cat. No.

A67441

CAS No.

977-96-8

Pseudoisocyanine iodide

Synonyms: 1,1'-Diethyl-2,2'-cyanine iodide; Decynium 22; Diethylcyanine iodide; Eastman 7851

Pseudoisocyanine iodide, also known as 1,1'-Diethyl-2,2'-cyanine iodide, functions as an inhibitor of organic cation transporters (OCT1, OCT2, OCT3) and the plasma membrane monoamine transporter (PMAT). This compound exhibits antidepressant activity, making it valuable for research in mental health and neuropharmacology. Its ability to modulate transporter function positions it as a useful tool for studying mechanisms of neurotransmitter regulation and potential therapeutic interventions in mood disorders.

Cat. No.

A67442

CAS No.

80663-95-2

m-Iodobenzylguanidine

Synonyms: MIBG; Iobenguane

m-Iodobenzylguanidine (Iobenguane) is a high-affinity ligand for the norepinephrine transporter (NET). This compound is primarily utilized as an imaging agent in diagnostic imaging and radionuclide studies for neuroendocrine tumors, including neuroblastoma, pheochromocytoma, and carcinoid tumors. Its role in tumor localization and assessment makes it a valuable tool in both research and clinical settings.

Cat. No.

A67443

CAS No.

926493-93-8

F3288-0031

F3288-0031 is an allosteric inhibitor of the norepinephrine transporter (NET), exhibiting a 73.5% inhibition rate at 20 μM. This compound binds to the inner vestibule of NET, stabilizing its inward-open conformation, and shows preferential inhibition of NET over the serotonin transporter (SERT) with a pIC50 of 5.9. In vitro studies demonstrate no significant off-target activity. F3288-0031 exhibits notable antidepressant-like effects in vivo, making it a valuable tool for research in depressive disorders and related neuropsychiatric conditions.

Cat. No.

A67444

CAS No.

70384-91-7

Lortalamine

Synonyms: LM 1404

Lortalamine is a selective inhibitor of the norepinephrine transporter, exhibiting an IC50 of less than 1 nM. This non-tricyclic antidepressant effectively inhibits norepinephrine uptake, demonstrating biological activity by antagonizing Reserpine-induced ptosis and hypothermia. Lortalamine serves as a valuable tool in research applications focused on neuropharmacology and depression mechanisms.

Cat. No.

A67445

CAS No.

1392826-25-3

Tetrabenazine-d6 (Ro 1-9569-d6)

Synonyms: Ro 1-9569-d6

Tetrabenazine-d6 is a deuterium-labeled analogue of Tetrabenazine, designed for improved stability and pharmacokinetic profiles in research. This compound primarily targets the vesicular monoamine transporter 2 (VMAT2), leading to decreased monoamine release and significant reduction in hyperkinetic movements. Tetrabenazine-d6 is instrumental in the study of Huntington's disease and various other hyperkinetic movement disorders, providing a valuable tool for understanding disease mechanisms and therapeutic interventions.

Cat. No.

A67447

CAS No.

1004548-96-2

FFN511

FFN511 is a potent fluorescent false neurotransmitter targeting the vesicular monoamine transporter 2 (VMAT2). With an IC50 of 1 µM, FFN511 effectively inhibits serotonin binding to VMAT2-containing membranes. This compound enables direct imaging of neurotransmitter release dynamics during exocytosis and is particularly useful for labeling dopamine terminals in live cortical-striatal acute slices, facilitating in-depth studies of synaptic function and neurotransmission.

Cat. No.

A67448

CAS No.

1026016-83-0

(+)-Tetrabenazine ((3R,11bR)-TBZ)

Synonyms: (+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine

(+)-Tetrabenazine is a reversible inhibitor of the vesicular monoamine transporter 2 (VMAT-2). It exhibits a potency that is 10-fold greater for VMAT-2 than for VMAT-1, effectively restricting monoamine transport. This compound is primarily utilized in research focused on neurochemical pathways and the treatment of movement disorders, such as Huntington's disease and tardive dyskinesia, by regulating dopamine levels in the synaptic cleft.

Cat. No.

A67449

CAS No.

2080306-27-8

FFN200 dihydrochloride

FFN200 dihydrochloride is a fluorescent substrate targeting the vesicular monoamine transporter 2 (VMAT2). This compound enables the selective tracing of monoamine exocytosis in neuronal cell cultures and brain tissue, making it a valuable tool for neuropharmacological studies. With fluorescence excitation and emission maxima at 352 nm and 451 nm, respectively, FFN200 dihydrochloride is well-suited for applications requiring high sensitivity and specificity in monitoring neurotransmitter release.

Cat. No.

A67450

CAS No.

1198790-53-2

Liafensine

Synonyms: BMS-820836

Liafensine is a potent triple monoamine reuptake inhibitor (TRI) that targets dopamine, serotonin, and norepinephrine transporters with respective IC50 values of 5.67 nM, 1.08 nM, and 7.99 nM. This compound demonstrates significant antidepressant activity, making it a valuable tool for research in mood disorders and neuropharmacology. Its ability to modulate multiple neurotransmitter systems highlights its potential for exploring therapeutic strategies in depressive and anxiety disorders.

Cat. No.

A67451

CAS No.

924854-62-6

(R,S,S)-Dihydrotetrabenazine

Synonyms: R,S,S-DHTBZ

(R,S,S)-Dihydrotetrabenazine is a secondary alcohol metabolite derived from Tetrabenazine, functioning primarily as a poor inhibitor of the vesicular monoamine transporter 2 (VMAT2) with a Ki value of 690 nM. This compound is utilized in neuropharmacological studies to investigate the modulation of monoamine transporters and their role in diseases such as Parkinson's and Huntington's. Its unique isomeric structure allows for in-depth research into the pharmacokinetics and pharmacodynamics of related compounds.

Cat. No.

A67452

CAS No.

3466-75-9

Dihydrotetrabenazine

Synonyms: DHTBZ

Dihydrotetrabenazine (DHTBZ) is a selective inhibitor of the vesicular monoamine transporter 2 (VMAT2). By decreasing the monoamine content in presynaptic neurons, it plays a crucial role in the study of movement disorders. DHTBZ is essential for investigating the mechanisms underlying neurotransmitter regulation and offers potential insights into therapeutic strategies for neurological diseases.

Cat. No.

A67453

CAS No.

2702382-98-5

4-Ethyl-N,N-Dmc hydrochloride

4-Ethyl-N,N-Dmc hydrochloride is a drug derivative acting as a non-selective substrate for monoamine transporters, which enhances the release of neurotransmitters. This compound is primarily utilized in research focused on the pharmacological effects of amphetamines and related substances. Its structural modifications offer insights into the development of novel psychoactive compounds and their interactions within the central nervous system.

Cat. No.

A67454

CAS No.

1026016-84-1

(-)-Tetrabenazine ((3S,11bS)-TBZ)

Synonyms: (-)-TBZ; (3S,11bS)-TBZ; (3S,11bS)-Tetrabenazine

(-)-Tetrabenazine is a specific inhibitor of the vesicular monoamine transporter 2 (VMAT2). This compound exhibits notable biological activity in the modulation of monoamine neurotransmitter levels, making it valuable for research in neuropharmacology and the study of movement disorders. Its role as a VMAT2 inhibitor can aid in the investigation of drug development for conditions such as Huntington's disease and other neurodegenerative disorders.

Cat. No.

A67455

CAS No.

1977511-05-9

(+)-Tetrabenazine-d6

(+)-Tetrabenazine-d6 is a deuterated form of the reversible inhibitor (+)-Tetrabenazine, which targets the vesicular monoamine transporter 2 (VMAT-2). This compound is utilized in research to investigate neurochemical processes and the role of monoamines in neurological disorders. Its isotopic labeling facilitates advanced metabolic studies and pharmacokinetic evaluations in biological systems.

Cat. No.

A67456

CAS No.

804-53-5

Tetrabenazine mesylate

Synonyms: Ro 1-9569 mesylate

Tetrabenazine mesylate is a potent reversible inhibitor of the vesicular monoamine transporter VMAT2, with a Kd value of 1.34 nM. This compound is primarily used in research focused on hyperactive movement disorders, including Huntington's disease, due to its ability to modulate monoamine neurotransmitter release. Tetrabenazine mesylate serves as a valuable tool for studying the underlying mechanisms of these neurological conditions and evaluating potential therapeutic approaches.

Cat. No.

A67459

CAS No.

924854-60-4

Tetrabenazine Metabolite

Synonyms: (-)-β-Dihydrotetrabenazine; (-)-β-HTBZ

Tetrabenazine Metabolite is a potent vesicular monoamine transporter 2 (VMAT2) inhibitor, exhibiting high affinity with a Ki of 13.4 nM. This active metabolite plays a crucial role in the modulation of monoamine neurotransmitter levels and is primarily investigated for its therapeutic potential in chorea associated with Huntington’s disease and other hyperkinetic disorders. Its mechanism of action supports ongoing research in neurological disease management and treatment strategies.

Cat. No.

A67460

CAS No.

2608770-12-1

VMAT2-IN-2 tosylate

VMAT2-IN-2 tosylate is a potent inhibitor of the vesicular monoamine transporter 2 (VMAT2). This compound is essential for investigating the pathophysiology of conditions such as tardive dyskinesia, where dysregulation of neurotransmitter storage and release plays a critical role. VMAT2-IN-2 tosylate may provide valuable insights into therapeutic strategies and the development of treatment options for related neurological disorders.

Cat. No.

A67461

CAS No.

171598-74-6

Trans (2,3)-Dihydrotetrabenazine

Synonyms: (2R,3R,11bR)-rel-Dihydrotetrabenazine; (2R,3R,11bR)-rel-DHTBZ

Trans (2,3)-Dihydrotetrabenazine is a metabolite of Tetrabenazine that primarily targets the vesicular monoamine transporter 2 (VMAT2). It exhibits significant inhibitory activity on VMAT2, contributing to altered monoamine storage and release. This compound is valuable for research applications in neuropharmacology and the study of movement disorders, providing insights into the modulation of neurotransmitter systems.

Cat. No.

A67464

CAS No.

2701977-99-1

Tetrabenazine-d7

Synonyms: TBZ-d7-d7; Ro 1-9569-d7

Tetrabenazine-d7 is a deuterium-labeled derivative of Tetrabenazine, a reversible inhibitor of the vesicular monoamine transporter VMAT2, demonstrating a Kd value of 1.34 nM. This compound is essential in biochemical research focused on hyperkinetic movement disorders, including Huntington's disease. The stable isotope labeling allows for enhanced tracking and analysis in metabolic studies and pharmacokinetic evaluations.

Cat. No.

A67465

CAS No.

86939-10-8

Indatraline

Synonyms: Lu 19005 free base

Indatraline is a potent monoamine reuptake inhibitor that targets the neuronal reuptake of neurotransmitters, including serotonin, norepinephrine, and dopamine. This compound demonstrates significant potential in research associated with neurological disorders, including depression and anxiety. Its long-acting properties make it an important tool for studying the modulation of monoamine neurotransmitter levels and their effects on neurobehavioral functions.