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MCHR1 (GPR24)

MCHR1 antagonists block melanin-concentrating hormone receptor 1 (MCHR1), a G protein-coupled receptor. Melanin-concentrating hormone (MCH) is a cyclic neuropeptide made mainly by neurons of the lateral hypothalamus. In 1999 two groups identified MCH as the ligand of an orphan receptor, now called MCHR1 or G protein-coupled receptor 24 (GPR24). Mice lacking MCH were hypophagic and lean in a 1998 study, which linked the peptide to feeding and energy balance. Antagonists are used in rodent models of food intake, body weight, anxiety and mood. SNAP 94847, NGD-4715 and BMS-819881 are listed MCHR1 antagonists, together with ATC0065 and SB-568849.

2 Items

  • (Phe13,Tyr19)-MCH (human, mouse, rat)
    Cat. No.
    A61608
    CAS No.
    160201-86-5

    (Phe13,Tyr19)-MCH (human, mouse, rat)

    (Phe13,Tyr19)-MCH (human, mouse, rat) is a selective agonist for the SLC-1 and S643b receptors. This compound exhibits robust biological activity that can be utilized to investigate the signaling pathways regulated by these receptors. It is suitable for research applications in neurobiology and pharmacology, providing valuable insights into receptor function and potential therapeutic targets.

    In stock View Details
    1 mg
    $160.00
    5 mg
    $360.00
    All 3 sizes
  • Ac-hMCH(6-16)-NH2
    Cat. No.
    A61609
    CAS No.
    353486-32-5

    Ac-hMCH(6-16)-NH2

    Ac-hMCH(6-16)-NH2 is a non-selective agonist targeting the human melanin-concentrating hormone (MCH) receptors, specifically MCH-1R and MCH-2R, with IC50 values of 0.16 nM and 2.7 nM, respectively. This compound effectively activates both receptor subtypes in the brain, making it a valuable tool for studying the physiological roles of MCH signaling. Research applications include investigations into metabolic regulation, feeding behavior, and neuroendocrine function.

    In stock View Details
    1 mg
    $30.00
    5 mg
    $80.00
    All 2 sizes

2 Items

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