Bradykinin Receptor

Cat. No.

A59122

CAS No.

159768-75-9

Lobradimil

Synonyms: RMP 7

Lobradimil, a synthetic bradykinin analog, acts as a potent and selective agonist of the bradykinin B2 receptor (Ki: 0.54 nM). This compound enhances blood-brain barrier permeability, making it valuable for investigations into neuropharmacology and brain tumor research. Its unique properties facilitate studies aimed at drug delivery across the blood-brain barrier and potential therapeutic applications in CNS disorders.

Cat. No.

A59124

CAS No.

194928-55-7

FR191413

FR191413 is a selective bradykinin B2 receptor agonist that activates bradykinin-mediated pathways including vasodilation and organ protection through the stimulation of prostaglandin E2 production in WI-38 cells. It competitively binds to [3H]-BK in guinea pig ileum membranes and CHO cells transfected with the human B2 receptor, exhibiting IC50 values of 20.0 nM and 2.60 nM, respectively. This compound is useful in researching cardiovascular conditions such as hypertension, myocardial hypertrophy, myocardial infarction, arrhythmias, and diabetic nephropathy.

Cat. No.

A59126

CAS No.

2763588-90-3

Lys-[Des-Arg9]Bradykinin TFA

Lys-[Des-Arg9]Bradykinin TFA is a selective agonist of the bradykinin B1 receptor, exhibiting high affinity with Ki values of 0.12 nM, 1.7 nM, and 0.23 nM for human, mouse, and rabbit B1 receptors, respectively. This compound demonstrates minimal inhibitory activity on B2 receptors, making it a valuable tool for studying the B1 receptor's role in inflammation and pain pathways. Its potent activity supports its use in various biological and pharmacological research applications focused on the modulation of kinin pathways.

Cat. No.

A59134

CAS No.

15958-92-6

[Des-Arg9]-Bradykinin

[Des-Arg9]-Bradykinin is a potent agonist of the bradykinin (B1) receptor, exhibiting selectivity for B1 receptors over B2 receptors. This selectivity allows for targeted studies on inflammation and pain pathways where B1 receptor activation plays a crucial role. It is primarily utilized in research focused on cardiovascular and renal physiology, as well as exploring potential therapeutic interventions for pain management.

Cat. No.

A59145

CAS No.

127819-95-8

L-366811

L-366811 is a bradykinin receptor agonist that stimulates phosphatidylinositol turnover and induces uterine contractions. This compound demonstrates activity in rat uterine slices, effectively promoting in vitro uterine contractions with moderate affinity for the [3H]BK binding site. L-366811 serves as a valuable tool for research in uterine physiology and related studies on bradykinin receptor signaling pathways.

Cat. No.

A59146

CAS No.

193344-25-1

FR-190997

FR-190997 is a selective agonist for the Bradykinin B2 receptor, with a Ki value of 9.8 nM. This non-peptide compound demonstrates significant biological activity as an antihypertensive agent. It is suitable for research applications focused on cardiovascular physiology and the study of bradykinin signaling pathways.

Cat. No.

A59150

CAS No.

113662-39-8

Lys-[Hyp3]-Bradykinin

Lys-[Hyp3]-Bradykinin is a potent bradykinin agonist that facilitates the activation of bradykinin receptors. This kinin, which can be isolated from human urine, is significant for studying inflammatory pathways and related biological responses. Its application extends to research in pain modulation, cardiovascular regulation, and various inflammatory conditions.

Cat. No.

A59152

CAS No.

550-19-6

Methionyl-Lysyl-Bradykinin

Synonyms: Met-Lys-Bradykinin

Methionyl-Lysyl-Bradykinin is a bradykinin receptor agonist that exhibits potent activity by mimicking the action of natural kinins. This peptide stimulates the bradykinin receptor, triggering various physiological responses such as vasodilation and pain perception modulation. It serves as a valuable tool in research focused on cardiovascular function, inflammation, and pain signaling pathways.

Cat. No.

A59159

CAS No.

509151-65-9

Bombinakinin M

Bombinakinin M is a bradykinin receptor agonist that exhibits contractile activity in the guinea pig ileum. This compound is of particular interest in studies exploring the physiological effects of bradykinin signaling pathways and gastrointestinal motility. Its ability to activate bradykinin receptors makes it a valuable tool for research in cardiovascular and inflammatory responses.

Cat. No.

A59162

CAS No.

118122-39-7

[Phe8Ψ(CH-NH)Arg9]-Bradykinin

[Phe8Ψ(CH-NH)Arg9]-Bradykinin is a selective agonist of the Bradykinin receptor B2, demonstrating resistance to cleavage by protein kinase I/II. This compound exhibits significant biological activity relevant to cardiovascular research, particularly in the study of hypertension. Its ability to selectively activate the B2 receptor positions it as a valuable tool for investigating bradykinin-related pathways in various physiological and pathological contexts.