Protein Kinase A (PKA)

Cat. No.

A37158

CAS No.

1134613-19-6

CW 008

CW 008 is a selective agonist of the cAMP/PKA/CREB signaling pathway. This pyrazole-pyridine derivative is known to stimulate osteoblast differentiation in human mesenchymal stem cells and enhance bone formation in ovariectomized mouse models. Additionally, CW 008 exhibits potential as a stem cell differentiating agent and suppresses leptin secretion, further contributing to its role in osteogenesis research.

Cat. No.

A37165

CAS No.

1573115-90-8

Sp-8-Br-cAMPS sodium

Sp-8-Br-cAMPS sodium is a potent protein kinase A (PKA) agonist, exhibiting an EC50 of 360 nM. This cAMP analog effectively activates PKA, leading to significant biological effects such as the inhibition of T cell proliferation and modulation of the hemocyte non-self response in Lepidoptera larvae. It serves as a valuable tool for investigating PKA-related signaling pathways and immune responses in various biological contexts.

Cat. No.

A37184

CAS No.

190522-24-8

8-Br-cAMP-AM

8-Br-cAMP-AM is a cyclic adenosine monophosphate (cAMP) analog that functions as a protein kinase A (PKA) agonist. By mimicking cAMP, it activates critical signaling pathways such as PKA and Epac, facilitating studies on heart-related conditions. This compound is particularly useful for investigating cardiac ischemia and reperfusion injury, providing valuable insights into these pathological processes.

Cat. No.

A37207

CAS No.

33823-18-6

8-MA-cAMP

Synonyms: 8-Methylamino-cAMP

8-MA-cAMP (8-Methylamino-cAMP) is a cyclic AMP analog that serves as a selective agonist for protein kinase A (PKA), specifically targeting the B site of both type I and type II PKA. This compound demonstrates key biological activity by effectively modulating PKA-mediated signaling pathways. Researchers utilize 8-MA-cAMP in combination with priming analogs, such as 8-piperidinyl cAMP, to achieve precise activation of type I PKA, making it valuable for studies in cellular signaling and related therapeutic research.

Cat. No.

A37225

CAS No.

127634-20-2

Sp-8-Br-cAMPS

Sp-8-Br-cAMPS is a synthetic analog of cyclic adenosine monophosphate (cAMP) and serves as a potent agonist for protein kinase A (PKA) with an EC50 of 360 nM. This compound effectively activates PKA and has been shown to inhibit T cell proliferation and modulate the hemocyte non-self response in Lepidoptera larvae. Its significant biological activity makes it a valuable tool for research into PKA-mediated signaling pathways and immune responses.