TAAR1

Cat. No.

A29521

CAS No.

3024777-79-2

TAAR1/5-H-2CR agonist-1

TAAR1/5-H-2CR Agonist-1 is a dual agonist targeting TAAR1 and the 5-HT2C receptor, demonstrating EC50 values of 0.022 μM and 0.246 μM, respectively. This compound plays a significant role in research related to psychiatric conditions, such as schizophrenia, and neurodegenerative diseases, including Alzheimer's Disease. Its ability to modulate these critical receptors makes it a valuable tool for investigating therapeutic pathways and mechanisms underlying these disorders.

Cat. No.

A29621

CAS No.

1281872-58-9

6-APDB hydrochloride

6-APDB hydrochloride is an agonist of the trace amine-associated receptor 1 (TAAR1). This compound also modulates 5-hydroxytryptamine receptors and acts as an inhibitor of the sodium-dependent noradrenaline transporter. Its unique profile suggests potential applications in neuropharmacology and behavioral research, particularly in studies related to mood regulation and neurotransmitter systems.

Cat. No.

A34150

CAS No.

1804128-38-8

TAAR1 agonist 2

TAAR1 Agonist 2 is a potent full agonist of trace amine-associated receptor 1 (TAAR1) with a pEC50 of 7.5. Additionally, it demonstrates agonistic activity at H1 receptors and activates various muscarinic acetylcholine receptors, including the M2 receptor (pEC50=5). This compound is valuable for research into neuropsychiatric diseases, providing insight into the modulation of these signaling pathways.

Cat. No.

A45899

CAS No.

2133417-13-5

Ralmitaront

Synonyms: RO6889450

Ralmitaront is an orally active agonist of trace amine-associated receptor 1 (TAAR1) with an EC50 of 110.4 nM. It exhibits antipsychotic, cognitive enhancement, and antidepressant effects in rodent models. Ralmitaront is valuable for investigating neuropsychiatric disorders, including schizophrenia and schizoaffective disorder, providing insights into potential therapeutic mechanisms and efficacy in neurosuppressant applications.

Cat. No.

A58699

CAS No.

1804129-70-1

TAAR1 agonist 3

TAAR1 Agonist 3 is a potent agonist of the trace amine-associated receptor 1 (TAAR1) with a pEC50 of 7.6. It also acts as a full agonist for the α2A receptor, exhibiting a pEC50 of 6. This compound is valuable for research into neuropsychiatric diseases, enabling the exploration of TAAR1 and α2A receptor functions in neurological contexts.

Cat. No.

A63952

CAS No.

1043495-96-0

RO5256390

RO5256390 is a potent agonist of the trace amine-associated receptor 1 (TAAR1). This compound demonstrates pro-cognitive and antidepressant-like effects in both rodent and primate models, exhibiting brain activation patterns akin to those seen with antipsychotic agents. Additionally, RO5256390 effectively reduces compulsive overeating behaviors in rats and inhibits ATP-induced TNF secretion in mouse bone marrow-derived macrophages, making it a valuable tool for research in neuropharmacology and appetite regulation.

Cat. No.

A63953

CAS No.

1357266-05-7

RO5263397

RO5263397 is a potent and selective agonist of the trace amine-associated receptor 1 (TAAR1), exhibiting EC50 values of 17 nM for human TAAR1 and 35 nM for rat TAAR1. This compound effectively modulates wakefulness and influences EEG spectral composition, demonstrating potential antidepressant-like properties. It serves as a valuable tool for investigating the role of TAAR1 in neuropsychiatric disorders and understanding its physiological functions.

Cat. No.

A63954

CAS No.

73918-56-6

ZH8651

ZH8651 is an agonist of the trace amine-associated receptor 1 (TAAR1), effectively activating both Gs and Gq signaling pathways. This compound is utilized in research related to schizophrenia and may contribute to understanding the role of TAAR1 in neuropsychiatric disorders. Its mechanism enables exploration of signaling dynamics and potential therapeutic targets in mental health research.

Cat. No.

A63955

CAS No.

1048346-74-2

RO5166017

RO5166017 is a potent agonist of the Trace Amine-Associated Receptor 1 (TAAR1) with Ki values of 1.9 nM, 2.7 nM, 31 nM, and 24 nM in mouse, rat, human, and cynomolgus monkey models, respectively. This orally active compound demonstrates cross-species functionality, making it an important tool for investigating TAAR1's role in neuropharmacology and potential therapeutic applications. It is suitable for research focused on the modulation of neurotransmitter systems and the pharmacological exploration of TAAR1-related pathways.

Cat. No.

A63956

CAS No.

1020814-70-3

RO 5073012

RO 5073012 is a selective agonist for the trace amine-associated receptor 1 (TAAR1), designed for oral administration with effective brain penetration. It demonstrates a Ki value of 6 nM for human TAAR1 and EC50 values of 23 nM and 25 nM for mouse and rat TAAR1, respectively. This compound is valuable for investigating the role of TAAR1 in neurological disorders, particularly schizophrenia, and may contribute to the development of novel therapeutic strategies.

Cat. No.

A63958

CAS No.

20388-87-8

2-Phenylpropan-1-amine hydrochloride

2-Phenylpropan-1-amine hydrochloride is identified as an agonist of the human trace amine-associated receptor 1 (TAAR1). This phenethylamine derivative exhibits significant biological activity by modulating monoaminergic signaling pathways. Its unique interaction with TAAR1 makes it a valuable tool for investigating the physiological roles of trace amines and their potential implications in neuropharmacology and psychiatric disorders.

Cat. No.

A63959

CAS No.

885466-70-6

ZH8659

ZH8659 is a potent agonist of the trace amine-associated receptor 1 (TAAR1) linked to the Gq signaling pathway. This compound demonstrates significant biological activity relevant to the study of schizophrenia and related psychiatric disorders. Its use in research can facilitate the understanding of TAAR1's role in neuropsychiatric conditions and aid in the development of therapeutic strategies.

Cat. No.

A63961

CAS No.

910387-04-1

ZH8667

ZH8667 is a selective TAAR1-Gs agonist that modulates neurotransmitter signaling pathways associated with trace amines. This compound is primarily utilized in research investigating the pathophysiology of schizophrenia and potential therapeutic interventions. Its ability to activate TAAR1 may contribute to the understanding of neuropsychiatric disorders and the development of novel treatments.

Cat. No.

A63962

CAS No.

4104-43-2

N-Methylphenethylamine hydrochloride

Synonyms: NMPEA hydrochloride

N-Methylphenethylamine hydrochloride is a potent agonist of the trace amine-associated receptor 1 (TAAR1). As a neuromodulator, it influences various neurotransmitter systems, which has implications in understanding mood regulation and neurochemical signaling. This compound is valuable for research in neuropharmacology and the role of trace amines in physiological processes.