Urotensin Receptor

Urotensin receptor ligands act on the urotensin II receptor (UT), a G protein-coupled receptor. In 1999, three groups showed that the cyclic peptide urotensin II is the endogenous ligand of the orphan G protein-coupled receptor 14 (GPR14), now named UT. Human urotensin II constricts isolated arteries strongly, and the receptor is found in heart, blood vessels, kidney and brain. Urotensin II-related peptide (URP) is a second endogenous ligand of the receptor. UT ligands are used in research on vascular tone, cardiac remodeling and kidney function. Palosuran, SB-706375 and SB-611812 are nonpeptide antagonists, and urantide is a peptide antagonist. Urotensin II-related peptide and human urotensin II (114-124) are listed as agonist peptides.

3 Items

  • Urotensin II (114-124), human
    Cat. No.
    A63985

    Urotensin II (114-124), human

    Urotensin II (114-124), human, is a peptide comprising 11 amino acids that functions as a potent vasoconstrictor and an agonist for the urotensin receptor (GPR14). This compound is utilized in research to explore cardiovascular function and pathophysiology, particularly regarding its role in regulating vascular tone and blood pressure. Its biological activity makes it a valuable tool for studying urotensin signaling pathways and their implications in various disease states.

    1 mg
    $110.00
    5 mg
    $460.00
    All 2 sizes
  • AC-7954 free base
    Cat. No.
    A63990

    AC-7954 free base

    AC-7954 free base is a selective nonpeptidic agonist of the urotensin receptor, demonstrating an EC50 of 300 nM at the human urotensin II receptor. This compound is valuable for research focused on the urotensin signaling pathway and its implications in cardiovascular and metabolic disorders. Its specificity makes it suitable for studies investigating the physiological and pathological roles of urotensin receptors in various biological systems.

    25 mg
    $1,275.00
    50 mg
    $1,625.00
    All 3 sizes
  • AC-7954
    Cat. No.
    A63992

    AC-7954

    AC-7954 is a selective nonpeptidic agonist of the urotensin receptor, exhibiting an EC50 of 300 nM at the human urotensin II receptor. This compound plays a significant role in cardiovascular and metabolic research, with potential applications in the study of hypertension and heart failure. AC-7954 can be utilized to explore urotensin-related signaling pathways and their implications in various physiological processes.

    1 mg
    $40.00
    5 mg
    $100.00
    All 7 sizes

3 Items

Added to your cart

View Cart Checkout

    Loading...