CGRP Receptor

Cat. No.

A58867

CAS No.

1776112-67-4

KBP-089

KBP-089 is a dual agonist of Amylin and Calcitonin receptors. This compound demonstrates significant biological activity by promoting weight reduction, decreasing adipose tissue mass, and enhancing glucose tolerance in obese rat models. Additionally, KBP-089 reduces lipid accumulation in both liver and muscle tissues while improving glycemic homeostasis and insulin sensitivity. It is particularly relevant for research focused on obesity and type 2 diabetes.

Cat. No.

A58870

CAS No.

2766385-23-1

Petrelintide

Synonyms: ZP8396

Petrelintide is a dual amylin and calcitonin receptor agonist (DACRA) that effectively modulates energy intake by selectively reducing high-fat diet consumption in diet-induced obese (DIO) rats. This compound promotes fat mass loss while preserving lean body mass throughout weight reduction processes. Petrelintide is valuable for research in diabetes and obesity, providing insights into the regulation of metabolic pathways associated with these conditions.

Cat. No.

A58878

CAS No.

863919-85-1

Davalintide

Davalintide is a potent agonist of the amylin receptor, calcitonin receptor, and calcitonin gene-related peptide (CGRP) receptor, demonstrating high affinity with IC50 values of 0.04 nM, 0.06 nM, and 3.1 nM, respectively. It effectively stimulates cyclic AMP production via the calcitonin receptor, with an EC50 of 1.4 nM. Davalintide has been shown to regulate blood glucose levels and body weight through mechanisms such as delaying gastric emptying, inhibiting glucagon secretion, and suppressing food intake. This peptide is valuable for research applications focused on obesity and diabetes management.

Cat. No.

A58883

CAS No.

2793341-99-6

Lenbelintide

Lenbelintide is a dual amylin and calcitonin receptor agonist, designed to engage both receptor pathways. This compound has demonstrated significant biological activity in modulating metabolic processes, making it valuable for research focused on obesity and related metabolic disorders. Its unique mechanism offers insights into appetite regulation and energy expenditure, providing a promising avenue for therapeutic exploration in weight management research.

Cat. No.

A58891

CAS No.

3108097-24-8

CTR/AMYR agonist-1 enantiomer

CTR/AMYR agonist-1 enantiomer is a potent agonist of the calcitonin receptor (CTR) and amylin receptor (AMYR), exhibiting EC50 values between 0.56 and 6.9 nM. This compound plays a crucial role in the study of metabolic diseases, facilitating research into the regulation of energy metabolism and glucose homeostasis. Its high specificity and efficacy make it an essential tool for investigating therapeutic targets within the CTR/AMYR signaling pathways.

Cat. No.

A58893

CAS No.

3108097-26-0

CTR/AMYR agonist-1

CTR/AMYR agonist-1 is a selective agonist for the Calcitonin Receptor (CTR) and Amylin Receptor (AMYR), exhibiting EC50 values ranging from 0.56 to 6.9 nM. This compound is instrumental in studying metabolic diseases, particularly in understanding the receptor-mediated pathways involved in energy homeostasis and glucose metabolism. Its high potency makes it a valuable tool for elucidating the physiological roles of CTR and AMYR in various biological contexts.

Cat. No.

A59630

CAS No.

158000-61-4

Calcitonin (salmon) (acetate)

Synonyms: Salmon calcitonin acetate

Calcitonin (salmon) (acetate) functions as a calcitonin gene-related peptide (CGRP) receptor agonist. This compound stimulates bone formation while inhibiting bone resorption, making it valuable for research in osteoporosis and other bone-related disorders. The acetate form enhances the absorption and bioactivity of the peptide, providing a more effective hormonal intervention for studies focusing on bone metabolism and calcium homeostasis.