Neuropeptide FF Receptor

Cat. No.

A62166

CAS No.

99566-27-5

Neuropeptide FF

Synonyms: NPFF

Neuropeptide FF (NPFF) functions as an agonist for the NPFF1 and NPFF2 receptors, exhibiting Ki values of 2.82 nM and 0.21 nM, respectively. This octapeptide plays a crucial role in mediating various physiological processes, including the modulation of pain, opioids, autonomic function, and neuroendocrine responses. It is involved in the regulation of memory and the control of food and water intake, while also demonstrating significant antiopioid and analgesic properties. Neuropeptide FF is particularly relevant for research into opioid tolerance, morphine-induced analgesia, abstinence syndrome, and pain-related conditions, including inflammatory and neuropathic pain.

Cat. No.

A62169

CAS No.

849335-07-5

AC-099 hydrochloride

AC-099 hydrochloride is a selective full agonist of the neuropeptide FF receptor 2 (NPFF2R) with an EC50 of 1189 nM, and a partial agonist of NPFF1R with an EC50 of 2370 nM. This compound has demonstrated the ability to attenuate hypersensitivity induced by spinal nerve ligation in rat models. AC-099 hydrochloride is valuable for research focusing on pain modulation and the neuropeptide signaling pathways associated with nociception.

Cat. No.

A62174

CAS No.

849459-88-7

AC-099

AC-099 is a selective agonist for the neuropeptide FF receptor 2 (NPFF2R) with an EC50 of 1189 nM and a partial agonist for NPFF1R, exhibiting an EC50 of 2370 nM. This compound demonstrates significant potential in modulating pain responses, as evidenced by its ability to attenuate spinal nerve ligation-induced hypersensitivity in rat models. AC-099 serves as a valuable tool in pain research and for exploring the roles of NPFF receptors in the central nervous system.

Cat. No.

A62203

CAS No.

311309-25-8

RFRP-1(human)

RFRP-1 (human) is a potent Neuropeptide FF (NPFF) receptor agonist that targets human gonadotropin-releasing hormone (GnRH) neurons and gonadotropes, effectively inhibiting gonadotropin release. This compound demonstrates high affinity for the NPFF receptors, with EC50 values of 0.0011 nM for NPFF2 and 29 nM for NPFF1. RFRP-1 (human) is valuable in research applications related to hormonal regulation and neuroendocrine signaling.

Cat. No.

A62262

CAS No.

230960-31-3

Neuropeptide SF(mouse,rat)

Neuropeptide SF (mouse, rat) is a potent agonist of the neuropeptide FF receptors, exhibiting Ki values of 48.4 nM for NPFF1 and 12.1 nM for NPFF2. This compound enhances the sustained current of heterologously expressed acid-sensing ion channel 3 (ASIC3), making it a valuable tool in studies related to pain modulation and neuropeptide signaling. Neuropeptide SF is ideal for research investigating neurophysiological processes and receptor interactions within neural pathways.