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Neuromedin U receptor ligands act on two receptors that mediate the effects of the peptide neuromedin U. Neuromedin U (NMU) was isolated in 1985 from porcine spinal cord as a peptide that contracts uterine smooth muscle and raises blood pressure. In 2000, two G protein-coupled receptors for NMU were identified, and central NMU was found to reduce food intake. Neuromedin U receptor 1 (NMUR1) is expressed mainly in peripheral tissues, whereas neuromedin U receptor 2 (NMUR2) is enriched in the brain. Neuromedin U, rat is the natural peptide ligand, and CPN-116 and NY0116 are listed as NMUR2 agonists. CPN-267 is annotated as an NMUR1 agonist, whereas R-PSOP and CPN-351 are antagonists of NMUR2 and NMUR1, respectively.
CPN-219 is a next-generation hexapeptidic agonist specifically targeting NMUR2. It demonstrates a selective and dose-dependent activation of NMUR2, with an EC50 value of 2.2 nM. This compound is invaluable for research applications aimed at understanding the physiological roles of NMUR2 in various biological processes.
CPN-116 is a selective agonist of the neuromedin U receptor 2 (NMUR2), which plays a critical role in the regulation of appetite and energy homeostasis. This compound has demonstrated potential biological activity in modulating metabolic processes, making it a valuable tool for research into obesity and related metabolic disorders. Its ability to activate NMUR2 may provide insights into developing therapeutic strategies for weight management and obesity treatment.
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3'-Methoxyflavonol is a selective agonist of the neuromedin U 2 receptor (NMU2R). It plays a significant role in various physiological processes, including modulation of appetite and anxiety behavior. This compound is useful in research applications focused on neuropeptide signaling pathways and their implications in metabolic and behavioral disorders.
CPN-267 is a selective agonist of the neuromedin U receptor 1 (NMUR1), demonstrating an EC50 of 0.25 nM. It has been shown to suppress body weight gain in mouse models, making it a valuable tool for research on obesity and related metabolic disorders.
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Synonyms: Neuromedin U (rat); Rat neuromedin U-23
Neuromedin U (rat) is a 23-amino acid neuropeptide that acts as an agonist for the NMUR2 receptor. This receptor-mediated action is crucial for the modulation of various physiological processes, including energy homeostasis, stress response, and pain perception. Neuromedin U is valuable for research investigating neuropeptide signaling pathways and their implications in metabolic disorders and stress-related conditions.
NY0116 is an agonist of the neuromedin U receptor 2 (NMUR2), exhibiting an EC50 of 13.61 μM for hNMUR2 and 27.76 μM for hNMUR1. This compound effectively reduces cAMP levels while enhancing calcium signaling in HEK293 cells stably expressing NMUR2. NY0116 is suitable for research applications involving neuropeptide signaling pathways and their physiological implications.
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