Leukotriene Receptor

Cat. No.

A60979

CAS No.

54397-84-1

12S-HHT

Synonyms: 12(S)-HHTrE

12S-HHT is an agonist of the BLT2 receptor and an enzymatic product of prostaglandin H2 (PGH2) via cyclooxygenase (COX)-mediated metabolism of arachidonic acid. This compound serves as an endogenous ligand that fully activates BLT2 in vivo. Notably, 12S-HHT has demonstrated the ability to suppress UV-induced IL-6 synthesis in keratinocytes, highlighting its potential anti-inflammatory properties and its utility in inflammation-related research applications.

Cat. No.

A61000

CAS No.

862891-27-8

CAY10583

CAY10583 is a potent and selective full agonist of the Leukotriene B4 receptor type 2 (BLT2). This compound effectively promotes keratinocyte migration in vitro and enhances wound healing in vivo, making it a valuable tool for studies on tissue repair mechanisms. CAY10583 holds potential for therapeutic applications in the treatment of diabetic wounds and related conditions.

Cat. No.

A61015

CAS No.

120772-66-9

(Rac)-SC-45694

(Rac)-SC-45694 is a racemic mixture of SC-45694, which acts as a potent leukotriene B4 (LTB4) agonist, promoting neutrophil chemotaxis. It also exhibits antagonist properties that inhibit LTB4-induced neutrophil degranulation. This compound is essential for studies investigating neutrophil function and inflammation-related pathways, making it valuable for research in immunology and related fields.

Cat. No.

A61060

CAS No.

83709-73-3

12-epi-LTB4

12-epi-LTB4 is an agonist for the BLT1 and BLT2 receptors, exhibiting partial agonistic activity against both mBLT1 and mBLT2. This compound has been shown to induce phosphorylation of extracellular signal-regulated kinase in primary mouse keratinocytes, highlighting its significance in signaling pathways. It is useful for research applications focused on investigating inflammatory responses and chemotaxis in cellular models.

Cat. No.

A61066

CAS No.

1927834-56-7

SC-45694 lithium

SC-45694 lithium is an LTB4 analog that acts primarily as an agonist, enhancing neutrophil chemotaxis, while also functioning as an antagonist by inhibiting LTB4-induced degranulation. This dual activity makes SC-45694 lithium a valuable tool for studying inflammatory responses and the role of leukotrienes in immune regulation. Its applications in research include investigations into chemotactic mechanisms and the modulation of immune cell functions.

Cat. No.

A61077

CAS No.

108806-41-3

YM-17690

YM-17690 is a potent agonist of leukotriene D4 (LTD4) and leukotriene E4 (LTE4), exhibiting a pKi value of 9.28 for [3H]LTD4 binding. It induces dose-dependent contractions in guinea pig ileum, lung parenchyma, and trachea, with EC50 values of 16 nM, 3.9 nM, and 22 nM, respectively. This compound is valuable for research focused on asthma, inflammation, and related respiratory conditions.