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MRGPR

MRGPR ligands act on Mas-related G protein-coupled receptors found on sensory neurons and mast cells. Mas-related G protein-coupled receptors (MRGPRs) were described in 2001 as a large family expressed in subsets of nociceptive sensory neurons. In 2009, mouse Mrgprs were shown to act as itch receptors that mediate chloroquine-induced pruritus. A 2015 study linked the mast cell receptor Mrgprb2, the mouse ortholog of human Mas-related G protein-coupled receptor X2 (MRGPRX2), to pseudo-allergic drug reactions. Most compounds here act on MRGPRX2, including the antagonists Z-3578 and BER-5 and the agonist PAMP-12 (unmodified). ML382 acts on the related receptor Mas-related G protein-coupled receptor X1 (MRGPRX1) as a positive allosteric modulator. BAM(8-22), a bovine adrenal medulla peptide fragment, also activates MRGPRX1.

1 Item

  • PAMP-12 (unmodified)
    Cat. No.
    A56859
    CAS No.
    929905-12-4

    PAMP-12 (unmodified)

    PAMP-12 (unmodified) is an endogenous peptide that acts as an agonist for the MrgX2 receptor. It effectively reduces cAMP accumulation, elevates intracellular Ca2+ levels, enhances beta-arrestin recruitment, decreases IP-1, and increases phosphorylated ERK (phospho-ERK). PAMP-12 (unmodified) induces hypotension by inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells. This reagent is suitable for research applications focused on hypotension and ulcerative colitis.

    In stock View Details
    1 mg
    $65.00
    5 mg
    $165.00
    All 3 sizes

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