Natriuretic Peptide Receptor (NPR)

Cat. No.

A18281

CAS No.

124584-08-3

Nesiritide

Synonyms: Brain Natriuretic Peptide-32 human; BNP-32

Nesiritide, a recombinant form of human B-type natriuretic peptide, primarily functions as an agonist of natriuretic peptide receptors (NPRs), specifically NPR-A and NPR-C, with affinity constants of 7.3 pM and 13 pM, respectively. It effectively regulates the activation and inactivation of L-type calcium channels, resulting in significant vasodilatory, diuretic, and natriuretic effects. Nesiritide is utilized in research on cardiovascular diseases, particularly in models of heart failure and vascular remodeling following arterial injury.

Cat. No.

A61962

CAS No.

3055143-61-5

NPRA agonist-11

NPRA agonist-11 is a selective agonist of the natriuretic peptide receptor A (NPRA/NPR1), exhibiting AC50 values of 1.681 μM in humans and 0.989 μM in monkeys. This compound is integral to studies of cardiovascular diseases and may also be applicable in the exploration of related disorders. Its mechanism of action makes it a valuable tool for researchers investigating NPRA signaling pathways and their implications in physiological and pathological contexts.

Cat. No.

A61965

CAS No.

1684439-46-0

Nesiritide acetate

Synonyms: Brain Natriuretic Peptide-32 human acetate; BNP-32 acetate

Nesiritide acetate is a recombinant human B-type natriuretic peptide that acts as an agonist of natriuretic peptide receptors (NPRs), exhibiting Kd values of 7.3 pM and 13 pM for NPR-A and NPR-C, respectively. This compound regulates the activation and inactivation of L-type calcium channels, demonstrating significant vasodilatory, diuretic, and natriuretic actions. It is primarily utilized in the research of cardiovascular conditions, particularly heart failure and vascular remodeling following arterial injury.