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Platelet-Activating Factor (PAF) Receptors

Platelet-activating factor (PAF) receptor antagonists block a G protein-coupled receptor for an inflammatory lipid. PAF is released by platelets, leukocytes and endothelial cells and promotes platelet aggregation, leukocyte activation and vascular permeability. The PAF receptor was cloned by functional expression from guinea pig lung in 1991. Ginkgolide B and ginkgolide A are terpene lactones from Ginkgo biloba that serve as classic natural PAF receptor antagonists. Foropafant, tulopafant and 48740 RP are synthetic antagonists developed for the same receptor. Rupatadine fumarate also blocks the histamine H1 receptor, and CP-96486 also blocks the leukotriene D4 (LTD4) receptor. Further ligands of these receptors are found under Histamine Receptors and Leukotriene Receptor.

2 Items

  • Carbamyl-PAF
    Cat. No.
    A62928
    CAS No.
    91575-58-5

    Carbamyl-PAF

    Synonyms: C-PAF

    Carbamyl-PAF is an analog and agonist of platelet-activating factor (PAF). It exhibits potent biological activity by stimulating PAF receptors, which play a crucial role in mediating inflammatory responses. Due to its stability and resistance to metabolism in Raji lymphoblasts at 37°C, Carbamyl-PAF is an effective reagent for studying PAF-related signaling pathways and inflammation mechanisms.

    In stock View Details
    1 mg
    $150.00
    5 mg
    $615.00
    All 4 sizes
  • Butanoyl PAF
    Cat. No.
    A62936
    CAS No.
    85405-03-4

    Butanoyl PAF

    Butanoyl PAF is a potent platelet-activating factor (PAF) agonist that retains over 10% of PAF's biological activity. This compound is found in significantly higher concentrations in oxidized low-density lipoprotein compared to enzymatically generated PAF, exceeding it by more than 100-fold. Butanoyl PAF is valuable in research applications aimed at understanding PAF-mediated signaling pathways and their roles in various physiological and pathological processes.

    In stock View Details
    1 mg
    $70.00
    5 mg
    $350.00
    All 3 sizes

2 Items

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